Prognostic value, clinical relevance, and methodological gaps of tumor burden in neuroendocrine tumors (NETs): A systematic review of phase III randomized trials of medical therapies.

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Title: Prognostic value, clinical relevance, and methodological gaps of tumor burden in neuroendocrine tumors (NETs): A systematic review of phase III randomized trials of medical therapies.
Authors: Arrivi G; Oncology Unit, Department of Clinical and Molecular Medicine Sapienza University of Rome, Sant'Andrea University Hospital, Rome, Italy., Rinzivillo M; Digestive Disease Unit, Sant' Andrea University Hospital, ENETS Center of Excellence, Rome 00189, Italy., Badalamenti G; Department of Precision Medicine in Medical, Surgical and Critical Care (Me.Pre.C.C.), University of Palermo, Palermo, Italy., Filice A; Nuclear Medicine Unit, Azienda Unità Sanitaria Locale -IRCCS di Reggio Emilia, Reggio Emilia, Italy., Modica R; Department of Clinical Medicine and Surgery, University of Naples 'Federico II', Naples, Italy., Partelli S; Division of Pancreatic and Transplant Surgery, Pancreas Translational & Clinical Research Center, IRCCS San Raffaele Hospital, Milan, Italy; Vita-Salute San Raffaele University, Milan, Italy., Ricci C; Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy; Division of Pancreatic Surgery, AOUBO, Bologna, Italy., Rossi RE; Gastroenterology and Endoscopy Unit, IRCCS Humanitas Research Hospital, Rozzano, Italy; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy., Panzuto F; Digestive Disease Unit, Sant' Andrea University Hospital, ENETS Center of Excellence, Rome 00189, Italy; Department of Medical and Surgical Sciences and Translational Medicine, Sapienza University of Rome, Rome 00185, Italy. Electronic address: francesco.panzuto@uniroma1.it.
Source: Critical reviews in oncology/hematology [Crit Rev Oncol Hematol] 2026 Jan; Vol. 217, pp. 105059. Date of Electronic Publication: 2025 Nov 28.
Publication Type: Journal Article; Systematic Review
Journal Info: Publisher: Elsevier Scientific Publishers Country of Publication: Netherlands NLM ID: 8916049 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0461 (Electronic) Linking ISSN: 10408428 NLM ISO Abbreviation: Crit Rev Oncol Hematol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Prognostic value, clinical relevance, and methodological gaps of tumor burden in neuroendocrine tumors (NETs): A systematic review of phase III randomized trials of medical therapies.
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  Data: <searchLink fieldCode="AU" term="%22Arrivi+G%22">Arrivi G</searchLink>; Oncology Unit, Department of Clinical and Molecular Medicine Sapienza University of Rome, Sant'Andrea University Hospital, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Rinzivillo+M%22">Rinzivillo M</searchLink>; Digestive Disease Unit, Sant' Andrea University Hospital, ENETS Center of Excellence, Rome 00189, Italy.<br /><searchLink fieldCode="AU" term="%22Badalamenti+G%22">Badalamenti G</searchLink>; Department of Precision Medicine in Medical, Surgical and Critical Care (Me.Pre.C.C.), University of Palermo, Palermo, Italy.<br /><searchLink fieldCode="AU" term="%22Filice+A%22">Filice A</searchLink>; Nuclear Medicine Unit, Azienda Unità Sanitaria Locale -IRCCS di Reggio Emilia, Reggio Emilia, Italy.<br /><searchLink fieldCode="AU" term="%22Modica+R%22">Modica R</searchLink>; Department of Clinical Medicine and Surgery, University of Naples 'Federico II', Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Partelli+S%22">Partelli S</searchLink>; Division of Pancreatic and Transplant Surgery, Pancreas Translational & Clinical Research Center, IRCCS San Raffaele Hospital, Milan, Italy; Vita-Salute San Raffaele University, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Ricci+C%22">Ricci C</searchLink>; Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy; Division of Pancreatic Surgery, AOUBO, Bologna, Italy.<br /><searchLink fieldCode="AU" term="%22Rossi+RE%22">Rossi RE</searchLink>; Gastroenterology and Endoscopy Unit, IRCCS Humanitas Research Hospital, Rozzano, Italy; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Panzuto+F%22">Panzuto F</searchLink>; Digestive Disease Unit, Sant' Andrea University Hospital, ENETS Center of Excellence, Rome 00189, Italy; Department of Medical and Surgical Sciences and Translational Medicine, Sapienza University of Rome, Rome 00185, Italy. Electronic address: francesco.panzuto@uniroma1.it.
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  Data: <searchLink fieldCode="JN" term="%228916049%22">Critical reviews in oncology/hematology</searchLink> [Crit Rev Oncol Hematol] 2026 Jan; Vol. 217, pp. 105059. <i>Date of Electronic Publication: </i>2025 Nov 28.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Scientific+Publishers%22">Elsevier Scientific Publishers </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>8916049 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1879-0461 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2210408428%22">10408428 </searchLink><i>NLM ISO Abbreviation: </i>Crit Rev Oncol Hematol <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41320144
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              Text: 2026 Jan
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              Y: 2026
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