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Rescuing fertility: C-Phycocyanin prevents ovarian damage through NRF2-mediated ferroptosis pathways in polycystic ovary syndrome models.

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Title: Rescuing fertility: C-Phycocyanin prevents ovarian damage through NRF2-mediated ferroptosis pathways in polycystic ovary syndrome models.
Authors: Zhang J; Department of Obstetrics and Gynecology, NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, China.; College of Grain Engineering, Anhui Vocational College of Grain Engineering, Hefei, Anhui 230011, China., Shen QS; Department of Obstetrics and Gynecology, NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, China.; Engineering Research Center of Biopreservation and Artificial Organs, Ministry of Education, Hefei, Anhui 230032, China., Chen YX; Department of Obstetrics and Gynecology, NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, China.; Engineering Research Center of Biopreservation and Artificial Organs, Ministry of Education, Hefei, Anhui 230032, China., Cheng HR; Department of Obstetrics and Gynecology, NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, China.; Engineering Research Center of Biopreservation and Artificial Organs, Ministry of Education, Hefei, Anhui 230032, China., Zhang W; Department of Obstetrics and Gynecology, NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, China.; Engineering Research Center of Biopreservation and Artificial Organs, Ministry of Education, Hefei, Anhui 230032, China., Xing T; Department of Obstetrics and Gynecology, NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, China.; Engineering Research Center of Biopreservation and Artificial Organs, Ministry of Education, Hefei, Anhui 230032, China., Liu YJ; Department of Obstetrics and Gynecology, NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, China.; Engineering Research Center of Biopreservation and Artificial Organs, Ministry of Education, Hefei, Anhui 230032, China., Cao YX; Department of Obstetrics and Gynecology, NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, China.; Engineering Research Center of Biopreservation and Artificial Organs, Ministry of Education, Hefei, Anhui 230032, China., Liang D; Department of Obstetrics and Gynecology, NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, China.; Engineering Research Center of Biopreservation and Artificial Organs, Ministry of Education, Hefei, Anhui 230032, China., Luo M; Department of Obstetrics and Gynecology, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, Henan 450007, China.; Zhengzhou City Key Laboratory of Endocrine Metabolism and Immunity in Polycystic Ovary Syndrome, Zhengzhou, Henan 450007, China. E-mail: luomanzz@zzu.edu.cn., Yu B; Department of Obstetrics and Gynecology, NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, China.; Engineering Research Center of Biopreservation and Artificial Organs, Ministry of Education, Hefei, Anhui 230032, China. E-mail: biaoyu@ahmu.edu.cn.
Source: Zoological research [Zool Res] 2025 Nov 18; Vol. 46 (6), pp. 1531-1548.
Publication Type: Journal Article
Journal Info: Publisher: Science Press Country of Publication: China NLM ID: 101697192 Publication Model: Print Cited Medium: Internet ISSN: 2095-8137 (Print) Linking ISSN: 20958137 NLM ISO Abbreviation: Zool Res Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Zhang+J%22">Zhang J</searchLink>; Department of Obstetrics and Gynecology, NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, China.; College of Grain Engineering, Anhui Vocational College of Grain Engineering, Hefei, Anhui 230011, China.<br /><searchLink fieldCode="AU" term="%22Shen+QS%22">Shen QS</searchLink>; Department of Obstetrics and Gynecology, NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, China.; Engineering Research Center of Biopreservation and Artificial Organs, Ministry of Education, Hefei, Anhui 230032, China.<br /><searchLink fieldCode="AU" term="%22Chen+YX%22">Chen YX</searchLink>; Department of Obstetrics and Gynecology, NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, China.; Engineering Research Center of Biopreservation and Artificial Organs, Ministry of Education, Hefei, Anhui 230032, China.<br /><searchLink fieldCode="AU" term="%22Cheng+HR%22">Cheng HR</searchLink>; Department of Obstetrics and Gynecology, NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, China.; Engineering Research Center of Biopreservation and Artificial Organs, Ministry of Education, Hefei, Anhui 230032, China.<br /><searchLink fieldCode="AU" term="%22Zhang+W%22">Zhang W</searchLink>; Department of Obstetrics and Gynecology, NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, China.; Engineering Research Center of Biopreservation and Artificial Organs, Ministry of Education, Hefei, Anhui 230032, China.<br /><searchLink fieldCode="AU" term="%22Xing+T%22">Xing T</searchLink>; Department of Obstetrics and Gynecology, NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, China.; Engineering Research Center of Biopreservation and Artificial Organs, Ministry of Education, Hefei, Anhui 230032, China.<br /><searchLink fieldCode="AU" term="%22Liu+YJ%22">Liu YJ</searchLink>; Department of Obstetrics and Gynecology, NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, China.; Engineering Research Center of Biopreservation and Artificial Organs, Ministry of Education, Hefei, Anhui 230032, China.<br /><searchLink fieldCode="AU" term="%22Cao+YX%22">Cao YX</searchLink>; Department of Obstetrics and Gynecology, NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, China.; Engineering Research Center of Biopreservation and Artificial Organs, Ministry of Education, Hefei, Anhui 230032, China.<br /><searchLink fieldCode="AU" term="%22Liang+D%22">Liang D</searchLink>; Department of Obstetrics and Gynecology, NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, China.; Engineering Research Center of Biopreservation and Artificial Organs, Ministry of Education, Hefei, Anhui 230032, China.<br /><searchLink fieldCode="AU" term="%22Luo+M%22">Luo M</searchLink>; Department of Obstetrics and Gynecology, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, Henan 450007, China.; Zhengzhou City Key Laboratory of Endocrine Metabolism and Immunity in Polycystic Ovary Syndrome, Zhengzhou, Henan 450007, China. E-mail: luomanzz@zzu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Yu+B%22">Yu B</searchLink>; Department of Obstetrics and Gynecology, NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, China.; Engineering Research Center of Biopreservation and Artificial Organs, Ministry of Education, Hefei, Anhui 230032, China. E-mail: biaoyu@ahmu.edu.cn.
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