View in EDS

Observational and Mendelian randomization studies of plasma sclerostin levels do not provide evidence of cardiovascular adverse effects of sclerostin inhibition.

Saved in:
Bibliographic Details
Title: Observational and Mendelian randomization studies of plasma sclerostin levels do not provide evidence of cardiovascular adverse effects of sclerostin inhibition.
Authors: Thorolfsdottir RB; Amgen deCODE Genetics, Sturlugata 8, 102 Reykjavik, Iceland., Sveinbjornsson G; Amgen deCODE Genetics, Sturlugata 8, 102 Reykjavik, Iceland., Hjorleifsson Eldjarn G; Amgen deCODE Genetics, Sturlugata 8, 102 Reykjavik, Iceland., Aegisdottir HM; Amgen deCODE Genetics, Sturlugata 8, 102 Reykjavik, Iceland.; Faculty of Medicine, School of Health Sciences, University of Iceland, Vatnsmyrarvegur 16, 101 Reykjavik, Iceland., Styrkarsdottir U; Amgen deCODE Genetics, Sturlugata 8, 102 Reykjavik, Iceland., Gretarsdottir S; Amgen deCODE Genetics, Sturlugata 8, 102 Reykjavik, Iceland., Steinthorsdottir V; Amgen deCODE Genetics, Sturlugata 8, 102 Reykjavik, Iceland., Tragante V; Amgen deCODE Genetics, Sturlugata 8, 102 Reykjavik, Iceland., Oddsson A; Amgen deCODE Genetics, Sturlugata 8, 102 Reykjavik, Iceland., Stefansdottir L; Amgen deCODE Genetics, Sturlugata 8, 102 Reykjavik, Iceland., Thorleifsson G; Amgen deCODE Genetics, Sturlugata 8, 102 Reykjavik, Iceland., Einarsson G; Amgen deCODE Genetics, Sturlugata 8, 102 Reykjavik, Iceland., Helgason H; Amgen deCODE Genetics, Sturlugata 8, 102 Reykjavik, Iceland.; School of Engineering and Natural Sciences, University of Iceland, Saemundargata 2, 102 Reykjavik, Iceland., Jonsdottir AB; Amgen deCODE Genetics, Sturlugata 8, 102 Reykjavik, Iceland.; Faculty of Medicine, School of Health Sciences, University of Iceland, Vatnsmyrarvegur 16, 101 Reykjavik, Iceland., Gudjonsson SA; Amgen deCODE Genetics, Sturlugata 8, 102 Reykjavik, Iceland., Ferkingstad E; Amgen deCODE Genetics, Sturlugata 8, 102 Reykjavik, Iceland., Brunak S; Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen, Denmark., Brøns N; Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark., Bundgaard JS; Department of Cardiology, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark., Bruun MT; Department of Clinical Immunology, Odense University Hospital, J. B. Winsløws Vej 4, 5000 Odense, Denmark., Erikstrup C; Department of Clinical Immunology, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, 8200 Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Palle H. Kristensens Vej 7, 8200  Denmark., Aagaard B; Department of Clinical Immunology, Aalborg University Hospital, Urbansgade 32-36, 9000 Aalborg, Denmark., Vesterager Pedersen OB; Department of Clinical Immunology, Zealand University Hospital, Lykkebækvej 1, 4600 Køge, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen, Denmark., Sibilitz KL; Department of Cardiology, Amager and Hvidovre University Hospital, Kettegård Allé 30, 2650 Hvidovre Copenhagen, Denmark., Sørensen E; Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark., Træholt J; Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark., Ullum H; Statens Serum Institut, Artillerivej 5, 2300 Copenhagen, Denmark., Zheng C; Department of Cardiology, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark., Knowlton KU; Intermountain Medical Center, Intermountain Heart Institute, 5121 South Cottonwood Street, Murray, UT 84107, United States.; School of Medicine, University of Utah, 30 N 1900 E, Salt Lake City, UT 84132, United States., Nadauld LD; Precision Genomics, Intermountain Healthcare, 600 S Medical Center Dr, Saint George, UT 84790, United States.; School of Medicine, Stanford University, Stanford, 291 Campus Drive, Li Ka Shing Building, CA 94305‑5101, United States., Ostrowski SR; Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen, Denmark., Bundgaard H; Department of Cardiology, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen, Denmark., Arnar DO; Amgen deCODE Genetics, Sturlugata 8, 102 Reykjavik, Iceland.; Faculty of Medicine, School of Health Sciences, University of Iceland, Vatnsmyrarvegur 16, 101 Reykjavik, Iceland.; Department of Cardiology, Landspitali, The National University Hospital of Iceland, Hringbraut, 101 Reykjavik, Iceland., Jonsdottir I; Amgen deCODE Genetics, Sturlugata 8, 102 Reykjavik, Iceland.; Faculty of Medicine, School of Health Sciences, University of Iceland, Vatnsmyrarvegur 16, 101 Reykjavik, Iceland.; Department of Immunology, Landspitali, The National University Hospital of Iceland, Hringbraut, 101 Reykjavik, Iceland., Helgadottir A; Amgen deCODE Genetics, Sturlugata 8, 102 Reykjavik, Iceland., Thorsteinsdottir U; Amgen deCODE Genetics, Sturlugata 8, 102 Reykjavik, Iceland.; Faculty of Medicine, School of Health Sciences, University of Iceland, Vatnsmyrarvegur 16, 101 Reykjavik, Iceland., Holm H; Amgen deCODE Genetics, Sturlugata 8, 102 Reykjavik, Iceland., Sulem P; Amgen deCODE Genetics, Sturlugata 8, 102 Reykjavik, Iceland., Gudbjartsson DF; Amgen deCODE Genetics, Sturlugata 8, 102 Reykjavik, Iceland.; School of Engineering and Natural Sciences, University of Iceland, Saemundargata 2, 102 Reykjavik, Iceland., Stefansson K; Amgen deCODE Genetics, Sturlugata 8, 102 Reykjavik, Iceland.; Faculty of Medicine, School of Health Sciences, University of Iceland, Vatnsmyrarvegur 16, 101 Reykjavik, Iceland.
Corporate Authors: DBDS Genomic Consortium
Source: Human molecular genetics [Hum Mol Genet] 2026 Feb 09; Vol. 35 (2).
Publication Type: Journal Article
Journal Info: Publisher: IRL Press at Oxford University Press Country of Publication: England NLM ID: 9208958 Publication Model: Print Cited Medium: Internet ISSN: 1460-2083 (Electronic) Linking ISSN: 09646906 NLM ISO Abbreviation: Hum Mol Genet Subsets: MEDLINE
Database: MEDLINE Ultimate
FullText Text:
  Availability: 0
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 41324467
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Observational and Mendelian randomization studies of plasma sclerostin levels do not provide evidence of cardiovascular adverse effects of sclerostin inhibition.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Thorolfsdottir+RB%22">Thorolfsdottir RB</searchLink>; Amgen deCODE Genetics, Sturlugata 8, 102 Reykjavik, Iceland.<br /><searchLink fieldCode="AU" term="%22Sveinbjornsson+G%22">Sveinbjornsson G</searchLink>; Amgen deCODE Genetics, Sturlugata 8, 102 Reykjavik, Iceland.<br /><searchLink fieldCode="AU" term="%22Hjorleifsson+Eldjarn+G%22">Hjorleifsson Eldjarn G</searchLink>; Amgen deCODE Genetics, Sturlugata 8, 102 Reykjavik, Iceland.<br /><searchLink fieldCode="AU" term="%22Aegisdottir+HM%22">Aegisdottir HM</searchLink>; Amgen deCODE Genetics, Sturlugata 8, 102 Reykjavik, Iceland.; Faculty of Medicine, School of Health Sciences, University of Iceland, Vatnsmyrarvegur 16, 101 Reykjavik, Iceland.<br /><searchLink fieldCode="AU" term="%22Styrkarsdottir+U%22">Styrkarsdottir U</searchLink>; Amgen deCODE Genetics, Sturlugata 8, 102 Reykjavik, Iceland.<br /><searchLink fieldCode="AU" term="%22Gretarsdottir+S%22">Gretarsdottir S</searchLink>; Amgen deCODE Genetics, Sturlugata 8, 102 Reykjavik, Iceland.<br /><searchLink fieldCode="AU" term="%22Steinthorsdottir+V%22">Steinthorsdottir V</searchLink>; Amgen deCODE Genetics, Sturlugata 8, 102 Reykjavik, Iceland.<br /><searchLink fieldCode="AU" term="%22Tragante+V%22">Tragante V</searchLink>; Amgen deCODE Genetics, Sturlugata 8, 102 Reykjavik, Iceland.<br /><searchLink fieldCode="AU" term="%22Oddsson+A%22">Oddsson A</searchLink>; Amgen deCODE Genetics, Sturlugata 8, 102 Reykjavik, Iceland.<br /><searchLink fieldCode="AU" term="%22Stefansdottir+L%22">Stefansdottir L</searchLink>; Amgen deCODE Genetics, Sturlugata 8, 102 Reykjavik, Iceland.<br /><searchLink fieldCode="AU" term="%22Thorleifsson+G%22">Thorleifsson G</searchLink>; Amgen deCODE Genetics, Sturlugata 8, 102 Reykjavik, Iceland.<br /><searchLink fieldCode="AU" term="%22Einarsson+G%22">Einarsson G</searchLink>; Amgen deCODE Genetics, Sturlugata 8, 102 Reykjavik, Iceland.<br /><searchLink fieldCode="AU" term="%22Helgason+H%22">Helgason H</searchLink>; Amgen deCODE Genetics, Sturlugata 8, 102 Reykjavik, Iceland.; School of Engineering and Natural Sciences, University of Iceland, Saemundargata 2, 102 Reykjavik, Iceland.<br /><searchLink fieldCode="AU" term="%22Jonsdottir+AB%22">Jonsdottir AB</searchLink>; Amgen deCODE Genetics, Sturlugata 8, 102 Reykjavik, Iceland.; Faculty of Medicine, School of Health Sciences, University of Iceland, Vatnsmyrarvegur 16, 101 Reykjavik, Iceland.<br /><searchLink fieldCode="AU" term="%22Gudjonsson+SA%22">Gudjonsson SA</searchLink>; Amgen deCODE Genetics, Sturlugata 8, 102 Reykjavik, Iceland.<br /><searchLink fieldCode="AU" term="%22Ferkingstad+E%22">Ferkingstad E</searchLink>; Amgen deCODE Genetics, Sturlugata 8, 102 Reykjavik, Iceland.<br /><searchLink fieldCode="AU" term="%22Brunak+S%22">Brunak S</searchLink>; Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Brøns+N%22">Brøns N</searchLink>; Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Bundgaard+JS%22">Bundgaard JS</searchLink>; Department of Cardiology, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Bruun+MT%22">Bruun MT</searchLink>; Department of Clinical Immunology, Odense University Hospital, J. B. Winsløws Vej 4, 5000 Odense, Denmark.<br /><searchLink fieldCode="AU" term="%22Erikstrup+C%22">Erikstrup C</searchLink>; Department of Clinical Immunology, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, 8200 Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Palle H. Kristensens Vej 7, 8200  Denmark.<br /><searchLink fieldCode="AU" term="%22Aagaard+B%22">Aagaard B</searchLink>; Department of Clinical Immunology, Aalborg University Hospital, Urbansgade 32-36, 9000 Aalborg, Denmark.<br /><searchLink fieldCode="AU" term="%22Vesterager+Pedersen+OB%22">Vesterager Pedersen OB</searchLink>; Department of Clinical Immunology, Zealand University Hospital, Lykkebækvej 1, 4600 Køge, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Sibilitz+KL%22">Sibilitz KL</searchLink>; Department of Cardiology, Amager and Hvidovre University Hospital, Kettegård Allé 30, 2650 Hvidovre Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Sørensen+E%22">Sørensen E</searchLink>; Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Træholt+J%22">Træholt J</searchLink>; Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Ullum+H%22">Ullum H</searchLink>; Statens Serum Institut, Artillerivej 5, 2300 Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Zheng+C%22">Zheng C</searchLink>; Department of Cardiology, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Knowlton+KU%22">Knowlton KU</searchLink>; Intermountain Medical Center, Intermountain Heart Institute, 5121 South Cottonwood Street, Murray, UT 84107, United States.; School of Medicine, University of Utah, 30 N 1900 E, Salt Lake City, UT 84132, United States.<br /><searchLink fieldCode="AU" term="%22Nadauld+LD%22">Nadauld LD</searchLink>; Precision Genomics, Intermountain Healthcare, 600 S Medical Center Dr, Saint George, UT 84790, United States.; School of Medicine, Stanford University, Stanford, 291 Campus Drive, Li Ka Shing Building, CA 94305‑5101, United States.<br /><searchLink fieldCode="AU" term="%22Ostrowski+SR%22">Ostrowski SR</searchLink>; Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Bundgaard+H%22">Bundgaard H</searchLink>; Department of Cardiology, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Arnar+DO%22">Arnar DO</searchLink>; Amgen deCODE Genetics, Sturlugata 8, 102 Reykjavik, Iceland.; Faculty of Medicine, School of Health Sciences, University of Iceland, Vatnsmyrarvegur 16, 101 Reykjavik, Iceland.; Department of Cardiology, Landspitali, The National University Hospital of Iceland, Hringbraut, 101 Reykjavik, Iceland.<br /><searchLink fieldCode="AU" term="%22Jonsdottir+I%22">Jonsdottir I</searchLink>; Amgen deCODE Genetics, Sturlugata 8, 102 Reykjavik, Iceland.; Faculty of Medicine, School of Health Sciences, University of Iceland, Vatnsmyrarvegur 16, 101 Reykjavik, Iceland.; Department of Immunology, Landspitali, The National University Hospital of Iceland, Hringbraut, 101 Reykjavik, Iceland.<br /><searchLink fieldCode="AU" term="%22Helgadottir+A%22">Helgadottir A</searchLink>; Amgen deCODE Genetics, Sturlugata 8, 102 Reykjavik, Iceland.<br /><searchLink fieldCode="AU" term="%22Thorsteinsdottir+U%22">Thorsteinsdottir U</searchLink>; Amgen deCODE Genetics, Sturlugata 8, 102 Reykjavik, Iceland.; Faculty of Medicine, School of Health Sciences, University of Iceland, Vatnsmyrarvegur 16, 101 Reykjavik, Iceland.<br /><searchLink fieldCode="AU" term="%22Holm+H%22">Holm H</searchLink>; Amgen deCODE Genetics, Sturlugata 8, 102 Reykjavik, Iceland.<br /><searchLink fieldCode="AU" term="%22Sulem+P%22">Sulem P</searchLink>; Amgen deCODE Genetics, Sturlugata 8, 102 Reykjavik, Iceland.<br /><searchLink fieldCode="AU" term="%22Gudbjartsson+DF%22">Gudbjartsson DF</searchLink>; Amgen deCODE Genetics, Sturlugata 8, 102 Reykjavik, Iceland.; School of Engineering and Natural Sciences, University of Iceland, Saemundargata 2, 102 Reykjavik, Iceland.<br /><searchLink fieldCode="AU" term="%22Stefansson+K%22">Stefansson K</searchLink>; Amgen deCODE Genetics, Sturlugata 8, 102 Reykjavik, Iceland.; Faculty of Medicine, School of Health Sciences, University of Iceland, Vatnsmyrarvegur 16, 101 Reykjavik, Iceland.
– Name: AuthorCorporate
  Label: Corporate Authors
  Group: Au
  Data: <searchLink fieldCode="CA" term="%22DBDS+Genomic+Consortium%22">DBDS Genomic Consortium</searchLink>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%229208958%22">Human molecular genetics</searchLink> [Hum Mol Genet] 2026 Feb 09; Vol. 35 (2).
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22IRL+Press+at+Oxford+University+Press%22">IRL Press at Oxford University Press </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>9208958 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1460-2083 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2209646906%22">09646906 </searchLink><i>NLM ISO Abbreviation: </i>Hum Mol Genet <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41324467
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1093/hmg/ddaf177
    Languages:
      – Code: eng
        Text: English
    Titles:
      – TitleFull: Observational and Mendelian randomization studies of plasma sclerostin levels do not provide evidence of cardiovascular adverse effects of sclerostin inhibition.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Thorolfsdottir RB
      – PersonEntity:
          Name:
            NameFull: Sveinbjornsson G
      – PersonEntity:
          Name:
            NameFull: Hjorleifsson Eldjarn G
      – PersonEntity:
          Name:
            NameFull: Aegisdottir HM
      – PersonEntity:
          Name:
            NameFull: Styrkarsdottir U
      – PersonEntity:
          Name:
            NameFull: Gretarsdottir S
      – PersonEntity:
          Name:
            NameFull: Steinthorsdottir V
      – PersonEntity:
          Name:
            NameFull: Tragante V
      – PersonEntity:
          Name:
            NameFull: Oddsson A
      – PersonEntity:
          Name:
            NameFull: Stefansdottir L
      – PersonEntity:
          Name:
            NameFull: Thorleifsson G
      – PersonEntity:
          Name:
            NameFull: Einarsson G
      – PersonEntity:
          Name:
            NameFull: Helgason H
      – PersonEntity:
          Name:
            NameFull: Jonsdottir AB
      – PersonEntity:
          Name:
            NameFull: Gudjonsson SA
      – PersonEntity:
          Name:
            NameFull: Ferkingstad E
      – PersonEntity:
          Name:
            NameFull: Brunak S
      – PersonEntity:
          Name:
            NameFull: Brøns N
      – PersonEntity:
          Name:
            NameFull: Bundgaard JS
      – PersonEntity:
          Name:
            NameFull: Bruun MT
      – PersonEntity:
          Name:
            NameFull: Erikstrup C
      – PersonEntity:
          Name:
            NameFull: Aagaard B
      – PersonEntity:
          Name:
            NameFull: Vesterager Pedersen OB
      – PersonEntity:
          Name:
            NameFull: Sibilitz KL
      – PersonEntity:
          Name:
            NameFull: Sørensen E
      – PersonEntity:
          Name:
            NameFull: Træholt J
      – PersonEntity:
          Name:
            NameFull: Ullum H
      – PersonEntity:
          Name:
            NameFull: Zheng C
      – PersonEntity:
          Name:
            NameFull: Knowlton KU
      – PersonEntity:
          Name:
            NameFull: Nadauld LD
      – PersonEntity:
          Name:
            NameFull: Ostrowski SR
      – PersonEntity:
          Name:
            NameFull: Bundgaard H
      – PersonEntity:
          Name:
            NameFull: Arnar DO
      – PersonEntity:
          Name:
            NameFull: Jonsdottir I
      – PersonEntity:
          Name:
            NameFull: Helgadottir A
      – PersonEntity:
          Name:
            NameFull: Thorsteinsdottir U
      – PersonEntity:
          Name:
            NameFull: Holm H
      – PersonEntity:
          Name:
            NameFull: Sulem P
      – PersonEntity:
          Name:
            NameFull: Gudbjartsson DF
      – PersonEntity:
          Name:
            NameFull: Stefansson K
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 09
              M: 02
              Text: 2026 Feb 09
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 1460-2083
          Numbering:
            – Type: volume
              Value: 35
            – Type: issue
              Value: 2
          Titles:
            – TitleFull: Human molecular genetics
              Type: main
ResultId 1