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Oxidized phosphatidylcholines deposition drives chronic neurodegeneration in a mouse model of progressive multiple sclerosis via IL-1β signaling.

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Title: Oxidized phosphatidylcholines deposition drives chronic neurodegeneration in a mouse model of progressive multiple sclerosis via IL-1β signaling.
Authors: Yu R; Department of Biochemistry, Microbiology & Immunology, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada., Lozinski BM; Hotchkiss Brain Institute and the Department of Clinical Neuroscience, University of Calgary, Calgary, Alberta, Canada.; Viral Immunology and Intravital Imaging Section, National Institute of Neurological Disorders and Stroke (NINDS), National Institute of Health (NIH), Bethesda, MD, USA., Seifert A; Department of Biochemistry, Microbiology & Immunology, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada., Ta K; Department of Biochemistry, Microbiology & Immunology, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada., Zandee S; Neuroimmunology Unit, The Research Center of the Centre Hospitalier de l'Université de Montréal (CRCHUM), Department of Neuroscience, Faculty of Medicine, Université de Montréal, Montréal, Quebec, Canada., Kaushik DK; Faculty of Medicine, Division of Biomedical Sciences, Memorial University of Newfoundland, St. John's, Newfoundland and Labrador, Canada., Park J; Department of Biochemistry, Microbiology & Immunology, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada., Klement W; Neuroimmunology Unit, The Research Center of the Centre Hospitalier de l'Université de Montréal (CRCHUM), Department of Neuroscience, Faculty of Medicine, Université de Montréal, Montréal, Quebec, Canada., Larouche S; Neuroimmunology Unit, The Research Center of the Centre Hospitalier de l'Université de Montréal (CRCHUM), Department of Neuroscience, Faculty of Medicine, Université de Montréal, Montréal, Quebec, Canada., Tsimikas S; Department of Medicine, University of California San Diego, San Diego, CA, USA., Witztum JL; Department of Medicine, University of California San Diego, San Diego, CA, USA., McGavern DB; Viral Immunology and Intravital Imaging Section, National Institute of Neurological Disorders and Stroke (NINDS), National Institute of Health (NIH), Bethesda, MD, USA., Prat A; Neuroimmunology Unit, The Research Center of the Centre Hospitalier de l'Université de Montréal (CRCHUM), Department of Neuroscience, Faculty of Medicine, Université de Montréal, Montréal, Quebec, Canada., Dong Y; Department of Biochemistry, Microbiology & Immunology, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada. jeff.dong@ubc.ca.
Source: Nature neuroscience [Nat Neurosci] 2026 Jan; Vol. 29 (1), pp. 67-80. Date of Electronic Publication: 2025 Dec 01.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 9809671 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1726 (Electronic) Linking ISSN: 10976256 NLM ISO Abbreviation: Nat Neurosci Subsets: MEDLINE
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  Data: Oxidized phosphatidylcholines deposition drives chronic neurodegeneration in a mouse model of progressive multiple sclerosis via IL-1β signaling.
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  Data: <searchLink fieldCode="AU" term="%22Yu+R%22">Yu R</searchLink>; Department of Biochemistry, Microbiology & Immunology, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.<br /><searchLink fieldCode="AU" term="%22Lozinski+BM%22">Lozinski BM</searchLink>; Hotchkiss Brain Institute and the Department of Clinical Neuroscience, University of Calgary, Calgary, Alberta, Canada.; Viral Immunology and Intravital Imaging Section, National Institute of Neurological Disorders and Stroke (NINDS), National Institute of Health (NIH), Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Seifert+A%22">Seifert A</searchLink>; Department of Biochemistry, Microbiology & Immunology, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.<br /><searchLink fieldCode="AU" term="%22Ta+K%22">Ta K</searchLink>; Department of Biochemistry, Microbiology & Immunology, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.<br /><searchLink fieldCode="AU" term="%22Zandee+S%22">Zandee S</searchLink>; Neuroimmunology Unit, The Research Center of the Centre Hospitalier de l'Université de Montréal (CRCHUM), Department of Neuroscience, Faculty of Medicine, Université de Montréal, Montréal, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Kaushik+DK%22">Kaushik DK</searchLink>; Faculty of Medicine, Division of Biomedical Sciences, Memorial University of Newfoundland, St. John's, Newfoundland and Labrador, Canada.<br /><searchLink fieldCode="AU" term="%22Park+J%22">Park J</searchLink>; Department of Biochemistry, Microbiology & Immunology, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.<br /><searchLink fieldCode="AU" term="%22Klement+W%22">Klement W</searchLink>; Neuroimmunology Unit, The Research Center of the Centre Hospitalier de l'Université de Montréal (CRCHUM), Department of Neuroscience, Faculty of Medicine, Université de Montréal, Montréal, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Larouche+S%22">Larouche S</searchLink>; Neuroimmunology Unit, The Research Center of the Centre Hospitalier de l'Université de Montréal (CRCHUM), Department of Neuroscience, Faculty of Medicine, Université de Montréal, Montréal, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Tsimikas+S%22">Tsimikas S</searchLink>; Department of Medicine, University of California San Diego, San Diego, CA, USA.<br /><searchLink fieldCode="AU" term="%22Witztum+JL%22">Witztum JL</searchLink>; Department of Medicine, University of California San Diego, San Diego, CA, USA.<br /><searchLink fieldCode="AU" term="%22McGavern+DB%22">McGavern DB</searchLink>; Viral Immunology and Intravital Imaging Section, National Institute of Neurological Disorders and Stroke (NINDS), National Institute of Health (NIH), Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Prat+A%22">Prat A</searchLink>; Neuroimmunology Unit, The Research Center of the Centre Hospitalier de l'Université de Montréal (CRCHUM), Department of Neuroscience, Faculty of Medicine, Université de Montréal, Montréal, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Dong+Y%22">Dong Y</searchLink>; Department of Biochemistry, Microbiology & Immunology, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada. jeff.dong@ubc.ca.
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  Data: <searchLink fieldCode="JN" term="%229809671%22">Nature neuroscience</searchLink> [Nat Neurosci] 2026 Jan; Vol. 29 (1), pp. 67-80. <i>Date of Electronic Publication: </i>2025 Dec 01.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group%22">Nature Publishing Group </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9809671 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1546-1726 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2210976256%22">10976256 </searchLink><i>NLM ISO Abbreviation: </i>Nat Neurosci <i>Subsets: </i>MEDLINE
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