Spatial transcriptomics expression prediction from histopathology based on cross-modal mask reconstruction and contrastive learning.

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Title: Spatial transcriptomics expression prediction from histopathology based on cross-modal mask reconstruction and contrastive learning.
Authors: Liu J; Faculty of Informatics and Data Science, University of Regensburg, Regensburg, Germany., Eckstein M; Institute of Pathology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany; Comprehensive Cancer Center Erlangen-EMN (CCC ER-EMN), Erlangen, Germany; Comprehensive Cancer Center Alliance WERA (CCC WERA), Erlangen, Germany; Bavarian Cancer Research Center (BZKF), Erlangen, Germany., Wang Z; Department of Ultrasound, Beijing Friendship Hospital, Capital Medical University, Beijing, China., Feuerhake F; Institute for Pathology, Hanover Medical School, Hannover, Germany; Institute for Neuropathology, University Clinic Freiburg, Freiburg im Breisgau, Germany., Merhof D; Faculty of Informatics and Data Science, University of Regensburg, Regensburg, Germany; Fraunhofer Institute for Digital Medicine MEVIS, Bremen, Germany. Electronic address: Dorit.Merhof@informatik.uni-regensburg.de.
Source: Medical image analysis [Med Image Anal] 2026 Feb; Vol. 108, pp. 103889. Date of Electronic Publication: 2025 Nov 25.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9713490 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1361-8423 (Electronic) Linking ISSN: 13618415 NLM ISO Abbreviation: Med Image Anal Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Liu+J%22">Liu J</searchLink>; Faculty of Informatics and Data Science, University of Regensburg, Regensburg, Germany.<br /><searchLink fieldCode="AU" term="%22Eckstein+M%22">Eckstein M</searchLink>; Institute of Pathology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany; Comprehensive Cancer Center Erlangen-EMN (CCC ER-EMN), Erlangen, Germany; Comprehensive Cancer Center Alliance WERA (CCC WERA), Erlangen, Germany; Bavarian Cancer Research Center (BZKF), Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Wang+Z%22">Wang Z</searchLink>; Department of Ultrasound, Beijing Friendship Hospital, Capital Medical University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Feuerhake+F%22">Feuerhake F</searchLink>; Institute for Pathology, Hanover Medical School, Hannover, Germany; Institute for Neuropathology, University Clinic Freiburg, Freiburg im Breisgau, Germany.<br /><searchLink fieldCode="AU" term="%22Merhof+D%22">Merhof D</searchLink>; Faculty of Informatics and Data Science, University of Regensburg, Regensburg, Germany; Fraunhofer Institute for Digital Medicine MEVIS, Bremen, Germany. Electronic address: Dorit.Merhof@informatik.uni-regensburg.de.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>9713490 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1361-8423 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2213618415%22">13618415 </searchLink><i>NLM ISO Abbreviation: </i>Med Image Anal <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.media.2025.103889
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              Text: 2026 Feb
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