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E3 ligase AREL1 controls perinuclear localization of lysosomes and supports Purkinje cell survival.

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Title: E3 ligase AREL1 controls perinuclear localization of lysosomes and supports Purkinje cell survival.
Authors: Jiang L; State Key Laboratory of Metabolism and Regulation in Complex Organisms, Hubei Provincial Research Center for Basic Biological Sciences, College of Life Sciences, Taikang Center for Life and Medical Sciences, Wuhan University, 430072, Wuhan, China., Tang J; State Key Laboratory of Metabolism and Regulation in Complex Organisms, Hubei Provincial Research Center for Basic Biological Sciences, College of Life Sciences, Taikang Center for Life and Medical Sciences, Wuhan University, 430072, Wuhan, China., Zhang YF; State Key Laboratory of Metabolism and Regulation in Complex Organisms, Hubei Provincial Research Center for Basic Biological Sciences, College of Life Sciences, Taikang Center for Life and Medical Sciences, Wuhan University, 430072, Wuhan, China., Zou WX; State Key Laboratory of Metabolism and Regulation in Complex Organisms, Hubei Provincial Research Center for Basic Biological Sciences, College of Life Sciences, Taikang Center for Life and Medical Sciences, Wuhan University, 430072, Wuhan, China., Deng G; State Key Laboratory of Metabolism and Regulation in Complex Organisms, Hubei Provincial Research Center for Basic Biological Sciences, College of Life Sciences, Taikang Center for Life and Medical Sciences, Wuhan University, 430072, Wuhan, China., Tian N; State Key Laboratory of Metabolism and Regulation in Complex Organisms, Hubei Provincial Research Center for Basic Biological Sciences, College of Life Sciences, Taikang Center for Life and Medical Sciences, Wuhan University, 430072, Wuhan, China., Zhao X; State Key Laboratory of Metabolism and Regulation in Complex Organisms, Hubei Provincial Research Center for Basic Biological Sciences, College of Life Sciences, Taikang Center for Life and Medical Sciences, Wuhan University, 430072, Wuhan, China., Han L; State Key Laboratory of Metabolism and Regulation in Complex Organisms, Hubei Provincial Research Center for Basic Biological Sciences, College of Life Sciences, Taikang Center for Life and Medical Sciences, Wuhan University, 430072, Wuhan, China., Liu K; State Key Laboratory of Metabolism and Regulation in Complex Organisms, Hubei Provincial Research Center for Basic Biological Sciences, College of Life Sciences, Taikang Center for Life and Medical Sciences, Wuhan University, 430072, Wuhan, China., Song BL; State Key Laboratory of Metabolism and Regulation in Complex Organisms, Hubei Provincial Research Center for Basic Biological Sciences, College of Life Sciences, Taikang Center for Life and Medical Sciences, Wuhan University, 430072, Wuhan, China., Luo J; State Key Laboratory of Metabolism and Regulation in Complex Organisms, Hubei Provincial Research Center for Basic Biological Sciences, College of Life Sciences, Taikang Center for Life and Medical Sciences, Wuhan University, 430072, Wuhan, China. jieluo@whu.edu.cn.
Source: The EMBO journal [EMBO J] 2026 Feb; Vol. 45 (3), pp. 655-691. Date of Electronic Publication: 2025 Dec 02.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8208664 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2075 (Electronic) Linking ISSN: 02614189 NLM ISO Abbreviation: EMBO J Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: E3 ligase AREL1 controls perinuclear localization of lysosomes and supports Purkinje cell survival.
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  Data: <searchLink fieldCode="AU" term="%22Jiang+L%22">Jiang L</searchLink>; State Key Laboratory of Metabolism and Regulation in Complex Organisms, Hubei Provincial Research Center for Basic Biological Sciences, College of Life Sciences, Taikang Center for Life and Medical Sciences, Wuhan University, 430072, Wuhan, China.<br /><searchLink fieldCode="AU" term="%22Tang+J%22">Tang J</searchLink>; State Key Laboratory of Metabolism and Regulation in Complex Organisms, Hubei Provincial Research Center for Basic Biological Sciences, College of Life Sciences, Taikang Center for Life and Medical Sciences, Wuhan University, 430072, Wuhan, China.<br /><searchLink fieldCode="AU" term="%22Zhang+YF%22">Zhang YF</searchLink>; State Key Laboratory of Metabolism and Regulation in Complex Organisms, Hubei Provincial Research Center for Basic Biological Sciences, College of Life Sciences, Taikang Center for Life and Medical Sciences, Wuhan University, 430072, Wuhan, China.<br /><searchLink fieldCode="AU" term="%22Zou+WX%22">Zou WX</searchLink>; State Key Laboratory of Metabolism and Regulation in Complex Organisms, Hubei Provincial Research Center for Basic Biological Sciences, College of Life Sciences, Taikang Center for Life and Medical Sciences, Wuhan University, 430072, Wuhan, China.<br /><searchLink fieldCode="AU" term="%22Deng+G%22">Deng G</searchLink>; State Key Laboratory of Metabolism and Regulation in Complex Organisms, Hubei Provincial Research Center for Basic Biological Sciences, College of Life Sciences, Taikang Center for Life and Medical Sciences, Wuhan University, 430072, Wuhan, China.<br /><searchLink fieldCode="AU" term="%22Tian+N%22">Tian N</searchLink>; State Key Laboratory of Metabolism and Regulation in Complex Organisms, Hubei Provincial Research Center for Basic Biological Sciences, College of Life Sciences, Taikang Center for Life and Medical Sciences, Wuhan University, 430072, Wuhan, China.<br /><searchLink fieldCode="AU" term="%22Zhao+X%22">Zhao X</searchLink>; State Key Laboratory of Metabolism and Regulation in Complex Organisms, Hubei Provincial Research Center for Basic Biological Sciences, College of Life Sciences, Taikang Center for Life and Medical Sciences, Wuhan University, 430072, Wuhan, China.<br /><searchLink fieldCode="AU" term="%22Han+L%22">Han L</searchLink>; State Key Laboratory of Metabolism and Regulation in Complex Organisms, Hubei Provincial Research Center for Basic Biological Sciences, College of Life Sciences, Taikang Center for Life and Medical Sciences, Wuhan University, 430072, Wuhan, China.<br /><searchLink fieldCode="AU" term="%22Liu+K%22">Liu K</searchLink>; State Key Laboratory of Metabolism and Regulation in Complex Organisms, Hubei Provincial Research Center for Basic Biological Sciences, College of Life Sciences, Taikang Center for Life and Medical Sciences, Wuhan University, 430072, Wuhan, China.<br /><searchLink fieldCode="AU" term="%22Song+BL%22">Song BL</searchLink>; State Key Laboratory of Metabolism and Regulation in Complex Organisms, Hubei Provincial Research Center for Basic Biological Sciences, College of Life Sciences, Taikang Center for Life and Medical Sciences, Wuhan University, 430072, Wuhan, China.<br /><searchLink fieldCode="AU" term="%22Luo+J%22">Luo J</searchLink>; State Key Laboratory of Metabolism and Regulation in Complex Organisms, Hubei Provincial Research Center for Basic Biological Sciences, College of Life Sciences, Taikang Center for Life and Medical Sciences, Wuhan University, 430072, Wuhan, China. jieluo@whu.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%228208664%22">The EMBO journal</searchLink> [EMBO J] 2026 Feb; Vol. 45 (3), pp. 655-691. <i>Date of Electronic Publication: </i>2025 Dec 02.
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        Value: 10.1038/s44318-025-00654-3
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        StartPage: 655
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      – TitleFull: E3 ligase AREL1 controls perinuclear localization of lysosomes and supports Purkinje cell survival.
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              Text: 2026 Feb
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