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Differential Effects of Sodium on Agonist-Induced Conformational Transitions and Signaling at μ and κ Opioid Receptors.

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Title: Differential Effects of Sodium on Agonist-Induced Conformational Transitions and Signaling at μ and κ Opioid Receptors.
Authors: Kuijer MB; Department of Pharmacology and NIMH Psychoactive Drug Screening Program, UNC Chapel Hill Medical School, Chapel Hill, North Carolina 27514, United States., Fulton CJ; Department of Pharmacology and NIMH Psychoactive Drug Screening Program, UNC Chapel Hill Medical School, Chapel Hill, North Carolina 27514, United States., Albert TL; Department of Pharmacology and NIMH Psychoactive Drug Screening Program, UNC Chapel Hill Medical School, Chapel Hill, North Carolina 27514, United States., Knobloch P; Department of Pharmacology and NIMH Psychoactive Drug Screening Program, UNC Chapel Hill Medical School, Chapel Hill, North Carolina 27514, United States., Wang J; Department of Pharmacology and NIMH Psychoactive Drug Screening Program, UNC Chapel Hill Medical School, Chapel Hill, North Carolina 27514, United States., Krumm BE; Department of Pharmacology and NIMH Psychoactive Drug Screening Program, UNC Chapel Hill Medical School, Chapel Hill, North Carolina 27514, United States., Che T; Center for Clinical Pharmacology, Department of Anesthesiology, Washington University School of Medicine, St. Louis, Missouri 63110, United States., Varga BR; Center for Clinical Pharmacology, Department of Anesthesiology, Washington University School of Medicine, St. Louis, Missouri 63110, United States., Majumdar S; Center for Clinical Pharmacology, Department of Anesthesiology, Washington University School of Medicine, St. Louis, Missouri 63110, United States., Katritch V; Department of Quantitative and Computational Biology, Department of Chemistry, USC Dornsife College of Arts and Sciences, and Department of Pharmacology and Pharmaceutical Sciences, USC Alfred E. Mann School of Pharmacy and Pharmaceutical Sciences, Los Angeles, California 90033, United States., Gumpper RH; Division of Medicinal Chemistry and Chemical Biology, UNC Eshelman School of Pharmacy, Chapel Hill, North Carolina 27514, United States., Kenakin T; Department of Pharmacology and NIMH Psychoactive Drug Screening Program, UNC Chapel Hill Medical School, Chapel Hill, North Carolina 27514, United States., Huang XP; Department of Pharmacology and NIMH Psychoactive Drug Screening Program, UNC Chapel Hill Medical School, Chapel Hill, North Carolina 27514, United States., Roth BL; Department of Pharmacology and NIMH Psychoactive Drug Screening Program, UNC Chapel Hill Medical School, Chapel Hill, North Carolina 27514, United States.
Source: Biochemistry [Biochemistry] 2025 Dec 16; Vol. 64 (24), pp. 4746-4757. Date of Electronic Publication: 2025 Dec 03.
Publication Type: Journal Article; Research Support, N.I.H., Extramural
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 0370623 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4995 (Electronic) Linking ISSN: 00062960 NLM ISO Abbreviation: Biochemistry Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Differential Effects of Sodium on Agonist-Induced Conformational Transitions and Signaling at μ and κ Opioid Receptors.
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        Value: 10.1021/acs.biochem.5c00526
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              Text: 2025 Dec 16
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