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Novel bis(triazole) analogues as selective TGR5 agonists with anti-diabesity effects.

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Title: Novel bis(triazole) analogues as selective TGR5 agonists with anti-diabesity effects.
Authors: Saxena A; Division of Medicinal and Process Chemistry, CSIR-Central Drug Research Institute, Lucknow, U.P. 226031, India; Jawaharlal Nehru University (JNU), New Delhi 110067, India., Kaushik D; Neuroscience and Ageing Biology Division, CSIR-Central Drug Research Institute, Lucknow, U.P. 226031, India; Jawaharlal Nehru University (JNU), New Delhi 110067, India., Kumar BA; Neuroscience and Ageing Biology Division, CSIR-Central Drug Research Institute, Lucknow, U.P. 226031, India; Jawaharlal Nehru University (JNU), New Delhi 110067, India., Rathaur S; Pharmaceutics & Pharmacokinetics Division, CSIR-Central Drug Research Institute, Lucknow, U.P. 226031, India; Jawaharlal Nehru University (JNU), New Delhi 110067, India., Chand D; Division of Medicinal and Process Chemistry, CSIR-Central Drug Research Institute, Lucknow, U.P. 226031, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, U.P. 201002, India., Srivastava KR; Division of Medicinal and Process Chemistry, CSIR-Central Drug Research Institute, Lucknow, U.P. 226031, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, U.P. 201002, India., Gayen JR; Pharmaceutics & Pharmacokinetics Division, CSIR-Central Drug Research Institute, Lucknow, U.P. 226031, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, U.P. 201002, India., Yadav PN; Neuroscience and Ageing Biology Division, CSIR-Central Drug Research Institute, Lucknow, U.P. 226031, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, U.P. 201002, India. Electronic address: pn.yadav@cdri.res.in., Ghosh N; Division of Medicinal and Process Chemistry, CSIR-Central Drug Research Institute, Lucknow, U.P. 226031, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, U.P. 201002, India. Electronic address: nayan.ghosh@cdri.res.in.
Source: Bioorganic chemistry [Bioorg Chem] 2026 Jan; Vol. 168, pp. 109286. Date of Electronic Publication: 2025 Nov 22.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Novel bis(triazole) analogues as selective TGR5 agonists with anti-diabesity effects.
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  Data: <searchLink fieldCode="AU" term="%22Saxena+A%22">Saxena A</searchLink>; Division of Medicinal and Process Chemistry, CSIR-Central Drug Research Institute, Lucknow, U.P. 226031, India; Jawaharlal Nehru University (JNU), New Delhi 110067, India.<br /><searchLink fieldCode="AU" term="%22Kaushik+D%22">Kaushik D</searchLink>; Neuroscience and Ageing Biology Division, CSIR-Central Drug Research Institute, Lucknow, U.P. 226031, India; Jawaharlal Nehru University (JNU), New Delhi 110067, India.<br /><searchLink fieldCode="AU" term="%22Kumar+BA%22">Kumar BA</searchLink>; Neuroscience and Ageing Biology Division, CSIR-Central Drug Research Institute, Lucknow, U.P. 226031, India; Jawaharlal Nehru University (JNU), New Delhi 110067, India.<br /><searchLink fieldCode="AU" term="%22Rathaur+S%22">Rathaur S</searchLink>; Pharmaceutics & Pharmacokinetics Division, CSIR-Central Drug Research Institute, Lucknow, U.P. 226031, India; Jawaharlal Nehru University (JNU), New Delhi 110067, India.<br /><searchLink fieldCode="AU" term="%22Chand+D%22">Chand D</searchLink>; Division of Medicinal and Process Chemistry, CSIR-Central Drug Research Institute, Lucknow, U.P. 226031, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, U.P. 201002, India.<br /><searchLink fieldCode="AU" term="%22Srivastava+KR%22">Srivastava KR</searchLink>; Division of Medicinal and Process Chemistry, CSIR-Central Drug Research Institute, Lucknow, U.P. 226031, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, U.P. 201002, India.<br /><searchLink fieldCode="AU" term="%22Gayen+JR%22">Gayen JR</searchLink>; Pharmaceutics & Pharmacokinetics Division, CSIR-Central Drug Research Institute, Lucknow, U.P. 226031, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, U.P. 201002, India.<br /><searchLink fieldCode="AU" term="%22Yadav+PN%22">Yadav PN</searchLink>; Neuroscience and Ageing Biology Division, CSIR-Central Drug Research Institute, Lucknow, U.P. 226031, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, U.P. 201002, India. Electronic address: pn.yadav@cdri.res.in.<br /><searchLink fieldCode="AU" term="%22Ghosh+N%22">Ghosh N</searchLink>; Division of Medicinal and Process Chemistry, CSIR-Central Drug Research Institute, Lucknow, U.P. 226031, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, U.P. 201002, India. Electronic address: nayan.ghosh@cdri.res.in.
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  Data: <searchLink fieldCode="JN" term="%221303703%22">Bioorganic chemistry</searchLink> [Bioorg Chem] 2026 Jan; Vol. 168, pp. 109286. <i>Date of Electronic Publication: </i>2025 Nov 22.
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              Text: 2026 Jan
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