Structural brain abnormalities and aggression in schizophrenia: mega-analysis of data from 2095 patients and 2861 healthy controls via the ENIGMA consortium.

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Title: Structural brain abnormalities and aggression in schizophrenia: mega-analysis of data from 2095 patients and 2861 healthy controls via the ENIGMA consortium.
Authors: Lamsma J; Department of Criminology, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands. j.lamsma@vu.nl.; Department of Psychiatry, University Medical Center Utrecht, Utrecht, the Netherlands. j.lamsma@vu.nl., Raine A; Department of Criminology, University of Pennsylvania, Philadelphia, PA, USA.; Department of Psychology, University of Pennsylvania, Philadelphia, PA, USA.; Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA., Kia SM; Department of Psychiatry, University Medical Center Utrecht, Utrecht, the Netherlands.; Department of Cognitive Science and Artificial Intelligence, Tilburg University, Tilburg, the Netherlands.; Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands., Cahn W; Department of Psychiatry, University Medical Center Utrecht, Utrecht, the Netherlands., Arold D; Division of Psychological and Social Medicine and Developmental Neurosciences, TU Dresden, Dresden, Germany., Banaj N; Laboratory of Neuropsychiatry, Santa Lucia Foundation IRCCS, Rome, Italy., Barone A; Department of Neurosciences, Reproductive Sciences and Dentistry, University of Naples Federico II, Naples, Italy., Brosch K; Department of Psychiatry and Psychotherapy, Philipps-University Marburg, Marburg, Germany.; Institute of Behavioral Science, Feinstein Institutes for Medical Research, Manhasset, NY, USA., Brouwer R; Department of Psychiatry, University Medical Center Utrecht, Utrecht, the Netherlands.; Department of Complex Trait Genetics, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands., Brunetti A; Department of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy., Calhoun VD; Tri-institutional Center for Translational Research in Neuroimaging and Data Science, Georgia State University, Georgia Institute of Technology and Emory University, Atlanta, GA, USA., Chew QH; Department of Research, Institute of Mental Health, Singapore, Singapore., Choi S; Department of Brain and Cognitive Sciences, Seoul National University College of Natural Sciences, Seoul, South Korea., Chung YC; Department of Psychiatry, Jeonbuk National University, Jeonju, South Korea.; Department of Psychiatry, Jeonbuk National University Hospital, Jeonju, South Korea.; Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju, South Korea., Ciccarelli M; Department of Neurosciences, Reproductive Sciences and Dentistry, University of Naples Federico II, Naples, Italy., Cobia D; Department of Psychology and Neuroscience Center, Brigham Young University, Provo, UT, USA., Cocozza S; Department of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy., Dannlowski U; Institute for Translational Psychiatry, University of Münster, Münster, Germany., Dazzan P; Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., de Bartolomeis A; Department of Neurosciences, Reproductive Sciences and Dentistry, University of Naples Federico II, Naples, Italy., Di Forti M; Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Dumais A; Department of Psychiatry and Addictology, University of Montreal, Montreal, Canada.; Institut Philippe-Pinel, Montreal, Canada., Edmond JT; Tri-institutional Center for Translational Research in Neuroimaging and Data Science, Georgia State University, Georgia Institute of Technology and Emory University, Atlanta, GA, USA.; Department of Psychology, Georgia State University, Atlanta, GA, USA., Ehrlich S; Division of Psychological and Social Medicine and Developmental Neurosciences, TU Dresden, Dresden, Germany.; Department of Child and Adolescent Psychiatry and Psychotherapy, TU Dresden, Dresden, Germany., Evermann U; Department of Psychiatry and Psychotherapy, Philipps-University Marburg, Marburg, Germany., Flinkenflügel K; Institute for Translational Psychiatry, University of Münster, Münster, Germany., Georgiadis F; Department of Psychiatry, Psychotherapy and Psychosomatics, University of Zürich, Zürich, Switzerland., Glahn DC; Department of Psychiatry, Harvard Medical School, Harvard, MA, USA.; Olin Neuropsychiatry Research Center, Institute of Living, Hartford, IN, USA., Goltermann J; Institute for Translational Psychiatry, University of Münster, Münster, Germany., Green MJ; Neuroscience Research Australia, Randwick, Australia.; School of Clinical Medicine, University of New South Wales, Sydney, Australia., Grotegerd D; Institute for Translational Psychiatry, University of Münster, Münster, Germany., Guerrero-Pedraza A; Hospital Benito Menni CASM, Barcelona, Spain., Ha M; Department of Brain and Cognitive Sciences, Seoul National University College of Natural Sciences, Seoul, South Korea., Hong EL; Department of Psychiatry and Behavioral Science, UTHealth Houston, Houston, TX, USA., Hulshoff Pol H; Department of Psychiatry, University Medical Center Utrecht, Utrecht, the Netherlands.; Department of Psychology, Utrecht University, Utrecht, the Netherlands., Iasevoli F; Department of Neurosciences, Reproductive Sciences and Dentistry, University of Naples Federico II, Naples, Italy., Kaiser S; Department of Psychiatry, University Hospitals of Geneva, Geneva, Switzerland., Kaleda V; Department of Youth Psychiatry, Mental Health Research Center, Moscow, Russia., Karuk A; FIDMAG Germanes Hospitalaries Research Foundation, Barcelona, Spain., Kim M; Department of Neuropsychiatry, Seoul National University Hospital, Seoul, South Korea.; Department of Psychiatry, Seoul National University College of Medicine, Seoul, South Korea., Kircher T; Department of Psychiatry and Psychotherapy, Philipps-University Marburg, Marburg, Germany., Kirschner M; Department of Psychiatry, Psychotherapy and Psychosomatics, University of Zürich, Zürich, Switzerland.; Department of Psychiatry, University Hospitals of Geneva, Geneva, Switzerland.; Montreal Neurological Institute-Hospital, McGill University, Montreal, Canada., Kochunov P; Department of Psychiatry and Behavioral Science, UTHealth Houston, Houston, TX, USA., Kwon JS; Department of Brain and Cognitive Sciences, Seoul National University College of Natural Sciences, Seoul, South Korea.; Department of Neuropsychiatry, Seoul National University Hospital, Seoul, South Korea.; Department of Psychiatry, Seoul National University College of Medicine, Seoul, South Korea., Lebedeva I; Laboratory of Neuroimaging and Multimodal Analysis, Mental Health Research Center, Moscow, Russia., Lencer R; Institute for Translational Psychiatry, University of Münster, Münster, Germany.; Department of Psychiatry and Psychotherapy, University of Lübeck, University of Lübeck, Lübeck, Germany., Marques TR; Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.; MRC London Institute of Medical Sciences, Imperial College London, London, UK.; Institute of Clinical Sciences, Imperial College London, London, UK., Meinert S; Institute for Translational Psychiatry, University of Münster, Münster, Germany.; Institute for Translational Neuroscience, University of Münster, Münster, Germany., Murray R; Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Nenadić I; Department of Psychiatry and Psychotherapy, Philipps-University Marburg, Marburg, Germany., Nguyen D; Department of Psychiatry and Human Behavior, University of California Irvine, Irvine, USA., Pearlson G; Olin Neuropsychiatry Research Center, Institute of Living, Hartford, IN, USA., Piras F; Laboratory of Neuropsychiatry, Santa Lucia Foundation IRCCS, Rome, Italy., Pomarol-Clotet E; FIDMAG Germanes Hospitalaries Research Foundation, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Salud Mental, Carlos III Health Institute, Madrid, Spain., Pontillo G; Department of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy.; Department of Electrical Engineering and Information Technology, University of Naples Federico II, Naples, Italy., Potvin S; Department of Psychiatry and Addictology, University of Montreal, Montreal, Canada.; Centre de Recherche de l'Institut Universitaire en Santé Mentale de Montréal, Montreal, Canada., Preda A; Department of Psychiatry and Human Behavior, University of California Irvine, Irvine, USA., Quidé Y; Neuroscience Research Australia, Randwick, Australia.; School of Psychology, University of New South Wales, Sydney, Australia., Rodrigue A; Department of Psychiatry, Harvard Medical School, Harvard, MA, USA., Rootes-Murdy K; Tri-institutional Center for Translational Research in Neuroimaging and Data Science, Georgia State University, Georgia Institute of Technology and Emory University, Atlanta, GA, USA.; Department of Psychology, Georgia State University, Atlanta, GA, USA., Salvador R; FIDMAG Germanes Hospitalaries Research Foundation, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Salud Mental, Carlos III Health Institute, Madrid, Spain., Sim K; Department of Research, Institute of Mental Health, Singapore, Singapore., Skoch A; National Institute of Mental Health, Klecany, Czech Republic., Spalletta G; Laboratory of Neuropsychiatry, Santa Lucia Foundation IRCCS, Rome, Italy., Spaniel F; National Institute of Mental Health, Klecany, Czech Republic., Stein F; Department of Psychiatry and Psychotherapy, Philipps-University Marburg, Marburg, Germany., Thomas-Odenthal F; Department of Psychiatry and Psychotherapy, Philipps-University Marburg, Marburg, Germany., Tikàsz A; Department of Psychiatry and Addictology, University of Montreal, Montreal, Canada.; Centre de Recherche de l'Institut Universitaire en Santé Mentale de Montréal, Montreal, Canada., Tomecek D; National Institute of Mental Health, Klecany, Czech Republic.; Institute of Computer Science, Czech Academy of Sciences, Prague, Czech Republic.; Faculty of Electrical Engineering, Czech Technical University in Prague, Prague, Czech Republic., Tomyshev A; Laboratory of Neuroimaging and Multimodal Analysis, Mental Health Research Center, Moscow, Russia., Tranfa M; Department of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy., Tsogt U; Department of Psychiatry, Jeonbuk National University, Jeonju, South Korea., Turner JA; Psychiatry and Behavioral Health, Ohio State University Wexner Medical Center, Columbus, USA., van Erp TGM; Department of Psychiatry and Human Behavior, University of California Irvine, Irvine, USA.; Center for the Neurobiology of Learning and Memory, University of California Irvine, Irvine, CA, USA., van Haren NEM; Department of Psychiatry, University Medical Center Utrecht, Utrecht, the Netherlands.; Department of Child and Adolescent Psychiatry and Psychology, Erasmus MC Sophia, Rotterdam, the Netherlands., van Os J; Department of Psychiatry, University Medical Center Utrecht, Utrecht, the Netherlands.; Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.; Department of Psychiatry and Neuropsychology, Maastricht University Medical Center, Maastricht, the Netherlands., Vecchio D; Laboratory of Neuropsychiatry, Santa Lucia Foundation IRCCS, Rome, Italy., Wang L; Psychiatry and Behavioral Health, Ohio State University Wexner Medical Center, Columbus, USA.; Department of Psychiatry and Behavioral Sciences, Northwestern University, Chicago, IL, USA., Wroblewski A; Department of Psychiatry and Psychotherapy, Philipps-University Marburg, Marburg, Germany., Nickl-Jockschat T; Department of Psychiatry and Psychotherapy, Otto-von-Guericke University, Magdeburg, Germany.; Department of Psychiatry, University of Iowa, Iowa City, IA, USA.; Iowa Neuroscience Institute, University of Iowa, Iowa City, IA, USA.
Source: Molecular psychiatry [Mol Psychiatry] 2026 Apr; Vol. 31 (4), pp. 2273-2282. Date of Electronic Publication: 2025 Dec 03.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Specialist Journals Country of Publication: England NLM ID: 9607835 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5578 (Electronic) Linking ISSN: 13594184 NLM ISO Abbreviation: Mol Psychiatry Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1476-5578
DOI:10.1038/s41380-025-03365-7