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A methodological review of pragmatic designs in acute stroke trials.

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Title: A methodological review of pragmatic designs in acute stroke trials.
Authors: Okikiolu AP; Department of Clinical Neurosciences & Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada.; Community Health Sciences, University of Calgary, Calgary, AB, Canada., Ray S; Department of Clinical Neurosciences & Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada.; Department of Neurology, Postgraduate Institute of Medical Education and Research, Chandigarh, India., Chakravarty K; Department of Neurology, Postgraduate Institute of Medical Education and Research, Chandigarh, India., Arimoro O; Community Health Sciences, University of Calgary, Calgary, AB, Canada., Martens R; Community Health Sciences, University of Calgary, Calgary, AB, Canada., Singh N; Department of Neurology, University of Manitoba, Winnipeg, MB, Canada., Ganesh A; Department of Clinical Neurosciences & Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada.; Community Health Sciences, University of Calgary, Calgary, AB, Canada.; Department of Radiology, University of Calgary, Calgary, AB, Canada., Almekhlafi M; Department of Clinical Neurosciences & Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada.; Community Health Sciences, University of Calgary, Calgary, AB, Canada.; Department of Radiology, University of Calgary, Calgary, AB, Canada., Hill MD; Department of Clinical Neurosciences & Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada.; Community Health Sciences, University of Calgary, Calgary, AB, Canada.; Department of Radiology, University of Calgary, Calgary, AB, Canada., Menon BK; Department of Clinical Neurosciences & Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada.; Community Health Sciences, University of Calgary, Calgary, AB, Canada.; Department of Radiology, University of Calgary, Calgary, AB, Canada., Sajobi TT; Department of Clinical Neurosciences & Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada.; Community Health Sciences, University of Calgary, Calgary, AB, Canada.
Source: International journal of stroke : official journal of the International Stroke Society [Int J Stroke] 2026 Jun; Vol. 21 (5), pp. 591-602. Date of Electronic Publication: 2025 Dec 05.
Publication Type: Journal Article; Review
Journal Info: Publisher: SAGE Publications Country of Publication: United States NLM ID: 101274068 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1747-4949 (Electronic) Linking ISSN: 17474930 NLM ISO Abbreviation: Int J Stroke Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: A methodological review of pragmatic designs in acute stroke trials.
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  Data: <searchLink fieldCode="AU" term="%22Okikiolu+AP%22">Okikiolu AP</searchLink>; Department of Clinical Neurosciences & Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada.; Community Health Sciences, University of Calgary, Calgary, AB, Canada.<br /><searchLink fieldCode="AU" term="%22Ray+S%22">Ray S</searchLink>; Department of Clinical Neurosciences & Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada.; Department of Neurology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.<br /><searchLink fieldCode="AU" term="%22Chakravarty+K%22">Chakravarty K</searchLink>; Department of Neurology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.<br /><searchLink fieldCode="AU" term="%22Arimoro+O%22">Arimoro O</searchLink>; Community Health Sciences, University of Calgary, Calgary, AB, Canada.<br /><searchLink fieldCode="AU" term="%22Martens+R%22">Martens R</searchLink>; Community Health Sciences, University of Calgary, Calgary, AB, Canada.<br /><searchLink fieldCode="AU" term="%22Singh+N%22">Singh N</searchLink>; Department of Neurology, University of Manitoba, Winnipeg, MB, Canada.<br /><searchLink fieldCode="AU" term="%22Ganesh+A%22">Ganesh A</searchLink>; Department of Clinical Neurosciences & Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada.; Community Health Sciences, University of Calgary, Calgary, AB, Canada.; Department of Radiology, University of Calgary, Calgary, AB, Canada.<br /><searchLink fieldCode="AU" term="%22Almekhlafi+M%22">Almekhlafi M</searchLink>; Department of Clinical Neurosciences & Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada.; Community Health Sciences, University of Calgary, Calgary, AB, Canada.; Department of Radiology, University of Calgary, Calgary, AB, Canada.<br /><searchLink fieldCode="AU" term="%22Hill+MD%22">Hill MD</searchLink>; Department of Clinical Neurosciences & Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada.; Community Health Sciences, University of Calgary, Calgary, AB, Canada.; Department of Radiology, University of Calgary, Calgary, AB, Canada.<br /><searchLink fieldCode="AU" term="%22Menon+BK%22">Menon BK</searchLink>; Department of Clinical Neurosciences & Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada.; Community Health Sciences, University of Calgary, Calgary, AB, Canada.; Department of Radiology, University of Calgary, Calgary, AB, Canada.<br /><searchLink fieldCode="AU" term="%22Sajobi+TT%22">Sajobi TT</searchLink>; Department of Clinical Neurosciences & Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada.; Community Health Sciences, University of Calgary, Calgary, AB, Canada.
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  Data: <searchLink fieldCode="JN" term="%22101274068%22">International journal of stroke : official journal of the International Stroke Society</searchLink> [Int J Stroke] 2026 Jun; Vol. 21 (5), pp. 591-602. <i>Date of Electronic Publication: </i>2025 Dec 05.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22SAGE+Publications%22">SAGE Publications </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101274068 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1747-4949 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2217474930%22">17474930 </searchLink><i>NLM ISO Abbreviation: </i>Int J Stroke <i>Subsets: </i>MEDLINE
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              Text: 2026 Jun
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