Molecular Plasticity Results in Oncofetal Reprogramming and Therapeutic Vulnerabilities in Juvenile Myelomonocytic Leukemia.
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| Title: | Molecular Plasticity Results in Oncofetal Reprogramming and Therapeutic Vulnerabilities in Juvenile Myelomonocytic Leukemia. |
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| Authors: | Hartmann M; Section of Translational Cancer Epigenomics, Division of Translational Medical Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.; National Center for Tumor Diseases (NCT) , NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany., Schönung M; Section of Translational Cancer Epigenomics, Division of Translational Medical Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.; National Center for Tumor Diseases (NCT) , NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; Faculty of Biosciences, Heidelberg University, Heidelberg, Germany., Rajak J; Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; Department of Pediatrics and Adolescent Medicine, University Medical Center Ulm, Ulm, Germany., Maurer V; Section of Translational Cancer Epigenomics, Division of Translational Medical Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.; National Center for Tumor Diseases (NCT) , NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; European Molecular Biology Laboratory Hamburg, Hamburg, Germany.; Centre for Structural Systems Biology (CSSB), Hamburg, Germany., Hai L; Bioinformatics and Omics Data Analytics, German Cancer Research Center (DKFZ), Heidelberg, Germany., Bauer K; scOPEN Lab, German Cancer Research Center (DKFZ), Heidelberg, Germany., Hakobyan M; Section of Translational Cancer Epigenomics, Division of Translational Medical Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.; National Center for Tumor Diseases (NCT) , NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; Faculty of Biosciences, Heidelberg University, Heidelberg, Germany., Stäble S; Section of Translational Cancer Epigenomics, Division of Translational Medical Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.; National Center for Tumor Diseases (NCT) , NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; Faculty of Biosciences, Heidelberg University, Heidelberg, Germany., Langstein J; Section of Translational Cancer Epigenomics, Division of Translational Medical Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.; National Center for Tumor Diseases (NCT) , NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; Faculty of Biosciences, Heidelberg University, Heidelberg, Germany., Jardine L; Biosciences Institute, Newcastle University, Newcastle upon Tyne, United Kingdom., Roelz R; Department of Neurosurgery, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Bohler S; Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Khabirova E; Wellcome Sanger Institute , Hinxton, United Kingdom., Maag AH; Institute of Experimental Cancer Research, University Hospital of Ulm, Ulm, Germany., Vonficht D; Faculty of Biosciences, Heidelberg University, Heidelberg, Germany.; Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ) and DKFZ-ZMBH Alliance, Heidelberg, Germany.; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), Heidelberg, Germany., Lebrecht D; Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Bernt KM; Division of Pediatric Oncology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania., Tan K; Center for Childhood Cancer Research, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.; Department of Pediatrics, University of Pennsylvania, Philadelphia, Pennsylvania., Chen C; Center for Childhood Cancer Research, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.; Department of Pediatrics, University of Pennsylvania, Philadelphia, Pennsylvania., Alikarami F; Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania., Meyer J; Department of Pediatrics, Benioff Children's Hospitals, University of California San Francisco, San Francisco, California., Wang J; Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; Department of Pediatrics and Adolescent Medicine, University Medical Center Ulm, Ulm, Germany., Boch T; Department of Hematology and Oncology, Heidelberg University, University Hospital Mannheim, Mannheim, Germany., Flore V; Section of Translational Cancer Epigenomics, Division of Translational Medical Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.; National Center for Tumor Diseases (NCT) , NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany., Lutsik P; Division of Cancer Epigenomics, German Cancer Research Center (DKFZ), Heidelberg, Germany., Milsom MD; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), Heidelberg, Germany.; Division of Experimental Hematology, German Cancer Research Center (DKFZ), Heidelberg, Germany., Raffel S; Department of Medicine, Hematology, Oncology and Rheumatology, University Hospital Heidelberg, Heidelberg, Germany., Buske C; Institute of Experimental Cancer Research, University Hospital of Ulm, Ulm, Germany., Haas S; Precision Healthcare University Research Institute, Queen Mary University of London, London, United Kingdom.; Berlin Institute of Health (BIH), Charité - Universitätsmedizin Berlin, Berlin, Germany.; Berlin Institute for Medical Systems Biology (BIMSB), Max Delbrück Center in the Helmholtz Association, Berlin, Germany., Haniffa M; Biosciences Institute, Newcastle University, Newcastle upon Tyne, United Kingdom.; Wellcome Sanger Institute , Hinxton, United Kingdom., Mallm JP; scOPEN Lab, German Cancer Research Center (DKFZ), Heidelberg, Germany., Behjati S; Wellcome Sanger Institute , Hinxton, United Kingdom.; Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom.; Department of Paediatrics, University of Cambridge, Cambridge, United Kingdom., Bonder MJ; Division of Computational Genomics and Systems Genetics, German Cancer Research Center, Heidelberg, Germany.; Genome Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany., Fröhling S; National Center for Tumor Diseases (NCT) , NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; Division of Translational Medical Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.; German Cancer Consortium (DKTK), Core Center Heidelberg, Heidelberg, Germany.; Institute of Human Genetics, Heidelberg University, Heidelberg, Germany., Stieglitz E; Department of Pediatrics, Benioff Children's Hospitals, University of California San Francisco, San Francisco, California., Niemeyer CM; Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; German Cancer Consortium (DKTK), partner site Freiburg, a partnership between DKFZ and University Medical Center Freiburg, Freiburg, Germany., Hey J; Division of Cancer Epigenomics, German Cancer Research Center (DKFZ), Heidelberg, Germany.; German-Israeli Helmholtz International Research School in Cancer Biology, Heidelberg, Germany., Flotho C; Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; German Cancer Consortium (DKTK), partner site Freiburg, a partnership between DKFZ and University Medical Center Freiburg, Freiburg, Germany., Plass C; Division of Cancer Epigenomics, German Cancer Research Center (DKFZ), Heidelberg, Germany., Erlacher M; Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; Department of Pediatrics and Adolescent Medicine, University Medical Center Ulm, Ulm, Germany.; German Cancer Consortium (DKTK), partner site Freiburg, a partnership between DKFZ and University Medical Center Freiburg, Freiburg, Germany., Schlesner M; Bioinformatics and Omics Data Analytics, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Faculty of Applied Computer Sciences, Biomedical Informatics, Data Mining and Data Analytics, University of Augsburg, Augsburg, Germany., Lipka DB; Section of Translational Cancer Epigenomics, Division of Translational Medical Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.; National Center for Tumor Diseases (NCT) , NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; German Cancer Consortium (DKTK), Core Center Heidelberg, Heidelberg, Germany.; Faculty of Medicine, Otto-von-Guericke-University, Magdeburg, Germany. |
| Source: | Blood cancer discovery [Blood Cancer Discov] 2026 Mar 04; Vol. 7 (2), pp. 306-330. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 101764786 Publication Model: Print Cited Medium: Internet ISSN: 2643-3249 (Electronic) Linking ISSN: 26433230 NLM ISO Abbreviation: Blood Cancer Discov Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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