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Novel indole-based indoleamine 2,3-dioxygenase-1 (IDO1) inhibitors: design, synthesis, and antidepressant evaluation.

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Title: Novel indole-based indoleamine 2,3-dioxygenase-1 (IDO1) inhibitors: design, synthesis, and antidepressant evaluation.
Authors: Zhang J; School of Biological Science and Technology, University of Jinan, Jinan 250022, China., Gao WJ; Shandong Laboratory of Yantai Drug Discovery, Bohai Rim Advanced Research Institute for Drug Discovery, Yantai, Shandong 264117, China., Zheng YX; School of Biological Science and Technology, University of Jinan, Jinan 250022, China., Shao JD; Advanced Medical Research Institute, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, China., Zhang NY; School of Biological Science and Technology, University of Jinan, Jinan 250022, China., Guo W; School of Biological Science and Technology, University of Jinan, Jinan 250022, China., Wang S; School of Biological Science and Technology, University of Jinan, Jinan 250022, China., Zhao Q; Cambrian Neuroscience Inc., No. 3-1, Xinjinhu Road, Jiangbei New District, Nanjing 210032, China., Zhu K; Advanced Medical Research Institute, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, China.; The Second Hospital of Shandong University, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, China.. Electronic address: hkhhh.k@163.com., Gao M; Cambrian Neuroscience Inc., No. 3-1, Xinjinhu Road, Jiangbei New District, Nanjing 210032, China. Electronic address: gaoming@cambrian-ns.com., Yu JH; Shandong Laboratory of Yantai Drug Discovery, Bohai Rim Advanced Research Institute for Drug Discovery, Yantai, Shandong 264117, China. Electronic address: jhyu@baridd.ac.cn., Meng N; School of Biological Science and Technology, University of Jinan, Jinan 250022, China. Electronic address: mls_mengn@ujn.edu.cn., Jiang CS; School of Biological Science and Technology, University of Jinan, Jinan 250022, China. Electronic address: bio_jiangcs@ujn.edu.cn.
Source: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2026 Feb; Vol. 133, pp. 118503. Date of Electronic Publication: 2025 Dec 02.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Country of Publication: England NLM ID: 9413298 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3391 (Electronic) Linking ISSN: 09680896 NLM ISO Abbreviation: Bioorg Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Novel indole-based indoleamine 2,3-dioxygenase-1 (IDO1) inhibitors: design, synthesis, and antidepressant evaluation.
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  Data: <searchLink fieldCode="AU" term="%22Zhang+J%22">Zhang J</searchLink>; School of Biological Science and Technology, University of Jinan, Jinan 250022, China.<br /><searchLink fieldCode="AU" term="%22Gao+WJ%22">Gao WJ</searchLink>; Shandong Laboratory of Yantai Drug Discovery, Bohai Rim Advanced Research Institute for Drug Discovery, Yantai, Shandong 264117, China.<br /><searchLink fieldCode="AU" term="%22Zheng+YX%22">Zheng YX</searchLink>; School of Biological Science and Technology, University of Jinan, Jinan 250022, China.<br /><searchLink fieldCode="AU" term="%22Shao+JD%22">Shao JD</searchLink>; Advanced Medical Research Institute, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, China.<br /><searchLink fieldCode="AU" term="%22Zhang+NY%22">Zhang NY</searchLink>; School of Biological Science and Technology, University of Jinan, Jinan 250022, China.<br /><searchLink fieldCode="AU" term="%22Guo+W%22">Guo W</searchLink>; School of Biological Science and Technology, University of Jinan, Jinan 250022, China.<br /><searchLink fieldCode="AU" term="%22Wang+S%22">Wang S</searchLink>; School of Biological Science and Technology, University of Jinan, Jinan 250022, China.<br /><searchLink fieldCode="AU" term="%22Zhao+Q%22">Zhao Q</searchLink>; Cambrian Neuroscience Inc., No. 3-1, Xinjinhu Road, Jiangbei New District, Nanjing 210032, China.<br /><searchLink fieldCode="AU" term="%22Zhu+K%22">Zhu K</searchLink>; Advanced Medical Research Institute, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, China.; The Second Hospital of Shandong University, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, China.. Electronic address: hkhhh.k@163.com.<br /><searchLink fieldCode="AU" term="%22Gao+M%22">Gao M</searchLink>; Cambrian Neuroscience Inc., No. 3-1, Xinjinhu Road, Jiangbei New District, Nanjing 210032, China. Electronic address: gaoming@cambrian-ns.com.<br /><searchLink fieldCode="AU" term="%22Yu+JH%22">Yu JH</searchLink>; Shandong Laboratory of Yantai Drug Discovery, Bohai Rim Advanced Research Institute for Drug Discovery, Yantai, Shandong 264117, China. Electronic address: jhyu@baridd.ac.cn.<br /><searchLink fieldCode="AU" term="%22Meng+N%22">Meng N</searchLink>; School of Biological Science and Technology, University of Jinan, Jinan 250022, China. Electronic address: mls_mengn@ujn.edu.cn.<br /><searchLink fieldCode="AU" term="%22Jiang+CS%22">Jiang CS</searchLink>; School of Biological Science and Technology, University of Jinan, Jinan 250022, China. Electronic address: bio_jiangcs@ujn.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%229413298%22">Bioorganic & medicinal chemistry</searchLink> [Bioorg Med Chem] 2026 Feb; Vol. 133, pp. 118503. <i>Date of Electronic Publication: </i>2025 Dec 02.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Science%22">Elsevier Science </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>9413298 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1464-3391 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2209680896%22">09680896 </searchLink><i>NLM ISO Abbreviation: </i>Bioorg Med Chem <i>Subsets: </i>MEDLINE
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              Text: 2026 Feb
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