Rapid transcellular hepatic copper depletion by ARBM-101 rescues severe liver damage in Wilson disease rodents.
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| Title: | Rapid transcellular hepatic copper depletion by ARBM-101 rescues severe liver damage in Wilson disease rodents. |
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| Authors: | Engler J; Institute of Toxicology and Environmental Hygiene, TUM School of Medicine and Health, Technical University of Munich, Munich, Germany., Kim EJ; R&D Center, ArborMed Co. Ltd, Pangyo, Seongnam, Gyeonggi-do, Republic of Korea., Kim D; R&D Center, ArborMed Co. Ltd, Pangyo, Seongnam, Gyeonggi-do, Republic of Korea., Shibata NM; Department of Internal Medicine, Division of Gastroenterology and Hepatology, University of California Davis, Davis, CA, USA., Lynderup EM; Department of Hepatology and Gastroenterology, Aarhus University Hospital, Aarhus, Denmark., Vendelbo MH; Department of Nuclear Medicine and PET Center, Aarhus University Hospital, Aarhus, Denmark; Department of Biomedicine, Aarhus University, Aarhus, Denmark., Akdogan B; Institute of Molecular Toxicology and Pharmacology, Helmholtz Munich, German Research Center for Environmental Health, Neuherberg, Germany., Sailer J; Institute of Toxicology and Environmental Hygiene, TUM School of Medicine and Health, Technical University of Munich, Munich, Germany., Fontes A; Institute of Toxicology and Environmental Hygiene, TUM School of Medicine and Health, Technical University of Munich, Munich, Germany; Institute of Molecular Toxicology and Pharmacology, Helmholtz Munich, German Research Center for Environmental Health, Neuherberg, Germany., Eberhagen C; Institute of Molecular Toxicology and Pharmacology, Helmholtz Munich, German Research Center for Environmental Health, Neuherberg, Germany., Rieder T; Institute of Toxicology and Environmental Hygiene, TUM School of Medicine and Health, Technical University of Munich, Munich, Germany., Reinold Q; Institute of Toxicology and Environmental Hygiene, TUM School of Medicine and Health, Technical University of Munich, Munich, Germany., Lee H; R&D Center, ArborMed Co. Ltd, Pangyo, Seongnam, Gyeonggi-do, Republic of Korea., Park D; R&D Center, ArborMed Co. Ltd, Pangyo, Seongnam, Gyeonggi-do, Republic of Korea., Jung C; R&D Center, ArborMed Co. Ltd, Pangyo, Seongnam, Gyeonggi-do, Republic of Korea., Im W; R&D Center, ArborMed Co. Ltd, Pangyo, Seongnam, Gyeonggi-do, Republic of Korea., Wudy SI; Bavarian Center for Biomolecular Mass Spectrometry (BayBioMS), TUM School of Life Sciences, Technical University of Munich, Freising, Germany., Kleigrewe K; Bavarian Center for Biomolecular Mass Spectrometry (BayBioMS), TUM School of Life Sciences, Technical University of Munich, Freising, Germany., Engelhardt S; Institute of Pharmacology and Toxicology, TUM School of Medicine and Health, Technical University of Munich, Munich, Germany., DiSpirito AA; Roy J. Carver Department of Biochemistry, Biophysics and Molecular Biology, Iowa State University, Ames, IA, USA., Sandahl TD; Department of Hepatology and Gastroenterology, Aarhus University Hospital, Aarhus, Denmark., Medici V; Department of Internal Medicine, Division of Gastroenterology and Hepatology, University of California Davis, Davis, CA, USA., Eun SY; R&D Center, ArborMed Co. Ltd, Pangyo, Seongnam, Gyeonggi-do, Republic of Korea., Zischka H; Institute of Toxicology and Environmental Hygiene, TUM School of Medicine and Health, Technical University of Munich, Munich, Germany; Institute of Molecular Toxicology and Pharmacology, Helmholtz Munich, German Research Center for Environmental Health, Neuherberg, Germany. Electronic address: hans.zischka@helmholtz-munich.de. |
| Source: | Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2025 Dec; Vol. 193, pp. 118867. Date of Electronic Publication: 2025 Dec 04. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 8213295 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1950-6007 (Electronic) Linking ISSN: 07533322 NLM ISO Abbreviation: Biomed Pharmacother Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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