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Advancing CNS tumor diagnostics with expanded DNA methylation-based classification.

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Title: Advancing CNS tumor diagnostics with expanded DNA methylation-based classification.
Authors: Sill M; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany. Electronic address: m.sill@kitz-heidelberg.de., Schrimpf D; Department of Neuropathology, University Hospital Heidelberg, Heidelberg, Germany; Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany., Patel A; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany; Department of Neuropathology, University Hospital Heidelberg, Heidelberg, Germany; Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany., Sturm D; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany; Division of Pediatric Glioma Research, German Cancer Research Center (DKFZ), Heidelberg, Germany., Jäger N; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany., Sievers P; Department of Neuropathology, University Hospital Heidelberg, Heidelberg, Germany; Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany., Schweizer L; Institute of Neurology (Edinger Institute), University Hospital Frankfurt, Goethe University, Frankfurt am Main, Germany; German Cancer Consortium (DKTK), Partner Site Frankfurt/Mainz, German Cancer Research Center (DKFZ), Heidelberg, Germany; Frankfurt Cancer Institute (FCI), Frankfurt am Main, Germany., Banan R; Department of Neuropathology, University Hospital Heidelberg, Heidelberg, Germany; Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany., Reuss D; Department of Neuropathology, University Hospital Heidelberg, Heidelberg, Germany; Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany., Suwala A; Department of Neuropathology, University Hospital Heidelberg, Heidelberg, Germany; Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany., Korshunov A; Department of Neuropathology, University Hospital Heidelberg, Heidelberg, Germany; Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany., Stichel D; Department of Neuropathology, University Hospital Heidelberg, Heidelberg, Germany; Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany., Wefers AK; Department of Neuropathology, Regensburg University Hospital, Regensburg, Germany; Mildred Scheel Cancer Career Center HaTriCS4, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Hau AC; Translational Neuro-Oncology Group, Dr. Senckenbergisches Institute for Neurooncology and Institute of Neurology (Edinger Institute), University Hospital, Goethe University Frankfurt am Main, Frankfurt am Main, Germany., Boldt H; Department of Pathology, Odense University Hospital, Odense, Denmark., Harter PN; Bavarian Cancer Research Center (BZKF), Partner Site Munich, Munich, Germany; German Cancer Consortium (DKTK), Partner Site Munich, a partnership between DKFZ and University/University Hospital, LMU Munich, Munich, Germany; Center for Neuropathology and Prion Research, Faculty of Medicine, LMU Munich, Munich, Germany., Abdullaev Z; Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA., Benhamida J; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York City, NY, USA., Teichmann D; Department of Neuropathology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany; German Cancer Consortium (DKTK), Partner Site Berlin, German Cancer Research Center (DKFZ), Heidelberg, Germany., Koch A; Department of Neuropathology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany; German Cancer Consortium (DKTK), Partner Site Berlin, German Cancer Research Center (DKFZ), Heidelberg, Germany., Hench J; Department of Neuropathology, Institute of Pathology, Basel University Hospital, Basel, Switzerland., Frank S; Department of Neuropathology, Institute of Pathology, Basel University Hospital, Basel, Switzerland., Hasselblatt M; Institute of Neuropathology, University Hospital Münster, Münster, Germany., Mansouri S; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada; MacFeeters Hamilton Neuro-Oncology Program, Princess Margaret Cancer Centre, University Health Network and University of Toronto, Toronto, ON, Canada., Díaz de Ståhl T; Department of Oncology-Pathology, Karolinska Institute, Stockholm, Sweden., Serrano J; Department of Pathology NYU Langone Health and NYU Grossman School of Medicine, New York, NY, USA., Ecker J; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany; KiTZ Clinical Trial Unit, Department of Pediatric Hematology and Oncology, Heidelberg University Hospital, Heidelberg, Germany; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ) and German Consortium for Translational Cancer Research (DKTK), Heidelberg, Germany., Selt F; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ) and German Consortium for Translational Cancer Research (DKTK), Heidelberg, Germany; Department of Pediatric Oncology, Hematology, Immunology and Pulmonology, University Hospital Heidelberg, Heidelberg, Germany., Taylor M; Department of Pediatrics- Hematology/Oncology, and Neurosurgery, Texas Children's Cancer Center, Hematology-Oncology Section, Baylor College of Medicine, Houston, TX, USA., Ramaswamy V; The Arthur and Sonia Labatt Brain Tumor Research Center, The Hospital for Sick Children, Toronto, ON, Canada; Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada., Cavalli F; Institut Curie, PSL Research University, Paris, France; Inserm, U900, Paris, France; MINES ParisTech, CBIO, Centre for Computational Biology, PSL Research University, 75006 Paris, France., Berghoff AS; Division of Oncology, Department of Medicine I, Medical University of Vienna, Vienna, Austria., Bison B; Department of Diagnostic and Interventional Neuroradiology, Faculty of Medicine, University of Augsburg, Augsburg, Germany., Blattner-Johnson M; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany; Division of Pediatric Glioma Research, German Cancer Research Center (DKFZ), Heidelberg, Germany; National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany., Buchhalter I; Omics IT and Data Management Core Facility, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany., Buslei R; Institute of Pathology, Sozialstiftung Bamberg, Klinikum am Bruderwald, Bamberg, Germany., Calaminus G; Department of Pediatric Hematology and Oncology, University Hospital Bonn, Bonn, Germany., Dikow N; Institute of Human Genetics, Heidelberg University Hospital, Heidelberg, Germany., Dohmen H; Institute of Neuropathology, University of Giessen, Giessen, Germany., Euskirchen P; Department of Neuropathology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany; German Cancer Consortium (DKTK), Partner Site Berlin, German Cancer Research Center (DKFZ), Heidelberg, Germany., Fleischhack G; Pediatrics III, University Hospital Essen, Essen, Germany., Gajjar A; Division of Neuro Oncology, Department of Oncology, St Jude Children's Research Hospital, Memphis, TN, USA., Gerber NU; Department of Oncology, University Children's Hospital, Zurich, Switzerland., Gessi M; Department of Life Sciences and Public Health, Università Cattolica Sacro Cuore, Rome, Italy., Gielen GH; Department of Neuropathology, University Hospital Bonn, Bonn, Germany., Gnekow A; Swabian Children's Cancer Center, Pediatric and Adolescent Medicine, Faculty of Medicine, University of Augsburg, Augsburg, Germany., Gottardo NG; Department of Pediatric and Adolescent Oncology/Haematology, Perth Children's Hospital, Nedlands, WA, Australia; Centre for Child Health Research, University of Western Australia, Nedlands, WA, Australia; Brain Tumour Research Program, Telethon Kids Institute, Nedlands, WA, Australia., Haberler C; Division of Neuropathology and Neurochemistry, Department of Neurology, Medical University of Vienna, Vienna, Austria., Hamelmann S; Department of Neuropathology, University Hospital Heidelberg, Heidelberg, Germany; Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany., Hans V; Department of Neuropathology, Institute for Clinical Pathology, Dietrich-Bonhoeffer-Klinikum, Neubrandenburg, Germany., Hansford JR; Michael Rice Centre for Hematology and Oncology, Women's and Children's Hospital, South Australia Health and Medical Research Institute, South Australia Immunogenomics Cancer Institute, University of Adelaide, Adelaide, SA, Australia., Hartmann C; Department of Neuropathology, Institute of Pathology, Hannover Medical School, Hannover, Germany., Heppner FL; Department of Neuropathology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany; German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany., Driever PH; Charité-Universitätsmedizin Berlin, Corporate member of Freie Universität Berlin and Humboldt-Universität Berlin, German HIT-LOGGIC-Registry for Children and Adolescents with Low-Grade Glioma, Department of Pediatric Oncology and Hematology, Berlin, Germany., von Hoff K; Department of Pediatric Oncology and Hematology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany; Department of Pediatric and Adolescent Medicine, Aarhus University Hospital, Aarhus, Denmark., Thomale UW; Pediatric Neurosurgery, Charité-Universitätsmedizin Berlin, Campus Virchow Klinikum, Berlin, Germany., Tippelt S; Pediatrics III, University Hospital Essen, Essen, Germany., Frühwald MC; Pediatrics and Adolescent Medicine, Swabian Children's Cancer Center, University Medical Center Augsburg and Bavarian Cancer Research Center/KIONET Bavaria, Augsburg, Bavaria, Germany., Kramm CM; Division of Pediatric Hematology and Oncology, University Medical Center Göttingen, Göttingen, Germany., Schüller U; Institute of Neuropathology and Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Germany, Research Institute Children's Cancer Center Hamburg, Hamburg, Germany., Schittenhelm J; Institute of Neuropathology, Department of Pathology and Neuropathology, University Hospital Tübingen, Eberhard Karls University Tübingen, Tübingen, Germany., Schuhmann MU; Section of Pediatric Neurosurgery, Department of Neurosurgery, University Hospital Tübingen, Tübingen, Germany., Stein M; Department of Neurosurgery, Justus-Liebig University, Giessen, Germany., Ketteler P; Pediatrics III, University Hospital Essen, Essen, Germany; Institute of Human Genetics, University Duisburg-Essen, Essen, Germany., Ladanyi M; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York City, NY, USA., Jabado N; Department of Pediatrics, McGill University, and The Research Institute of the McGill University Health Centre, Montreal, QC, Canada; Department of Human Genetics, McGill University, Montreal, QC, Canada., Jones BC; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany; Division of Pediatric Glioma Research, German Cancer Research Center (DKFZ), Heidelberg, Germany; Department of Pediatric Oncology, Hematology, Immunology and Pulmonology, University Hospital Heidelberg, Heidelberg, Germany., Jones C; Division of Molecular Pathology, The Institute of Cancer Research (ICR), Sutton, Surrey, UK., Karajannis MA; Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Ketter R; Department of Neurosurgery, Saarland University, Medical School, Homburg, Germany., Kohlhof P; Department for Pathology, Katharinenhospital Stuttgart, Stuttgart, Germany., Kordes U; Department of Pediatric Hematology/Oncology, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany., Reinhardt A; Department of Neuropathology, University Hospital Heidelberg, Heidelberg, Germany; Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany., Kölsche C; Institute of Pathology, LMU Munich, Munich, Germany., Lamszus K; Department of Neurosurgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Lichter P; National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany; Division of Molecular Genetics, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany., Maas SLN; Department of Pathology, Leiden University Medical Center, Leiden, the Netherlands; Department of Pathology, Erasmus MC Cancer Institute, University Medical Center Rotterdam, Rotterdam, the Netherlands., Mawrin C; Department of Neuropathology, Otto von Guericke University, Magdeburg, Germany., Milde T; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ) and German Consortium for Translational Cancer Research (DKTK), Heidelberg, Germany; Department of Pediatrics, Jena University Hospital and Comprehensive Cancer Center Central Germany (CCCG), Jena, Germany., Mittelbronn M; Luxembourg National Center of Pathology (NCP), Laboratoire National de Santé (LNS), Department of Cancer Research (DOCR), Luxembourg Institute of Health (LIH), Luxembourg Centre of Neuropathology (LCNP), Luxembourg Centre for Systems Biomedicine (LCSB), Faculty of Science, Technology and Medicine (FSTM) and Department of Life Sciences and Medicine (DLSM), University of Luxembourg, Esch-sur-Alzette, Luxembourg., Monoranu CM; Institute of Pathology, Department of Neuropathology, University of Würzburg, Würzburg, Germany., Mueller W; Department of Neuropathology, University of Leipzig, Leipzig, Germany., Mynarek M; Mildred Scheel Cancer Career Center HaTriCS4, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Department of Pediatric Hematology/Oncology, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany., Northcott PA; Center of Excellence in Neuro-Oncology Sciences, St. Jude Children's Research Hospital, Memphis, TN, USA; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN, USA., Pajtler KW; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany; Department of Pediatric Oncology, Hematology, Immunology and Pulmonology, University Hospital Heidelberg, Heidelberg, Germany., Paulus W; Institute of Neuropathology, University Hospital Münster, Münster, Germany., Perry A; Departments of Pathology and Neurological Surgery, UCSF, San Francisco, CA, USA., Blümcke I; Department of Neuropathology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Partner of the European Reference Network (ERN) EpiCARE, Erlangen, Germany., Plate KH; Institute of Neurology (Edinger Institute), University Hospital Frankfurt, Goethe University, Frankfurt am Main, Germany; German Cancer Consortium (DKTK), Partner Site Frankfurt/Mainz, German Cancer Research Center (DKFZ), Heidelberg, Germany; Frankfurt Cancer Institute (FCI), Frankfurt am Main, Germany., Platten M; National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany; Clinical Cooperation Unit (CCU) Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany; Department of Neurology, Medical Faculty Mannheim, Mannheim Center for Translation Neuroscience (MCTN), Heidelberg University, Mannheim, Germany; Helmholtz Institute for Translational Oncology Mainz (HI-TRON Mainz) - A Helmholtz Institute of the DKFZ, Mainz, Germany; DKFZ Hector Cancer Institute at the University Medical Center Mannheim, Mannheim, Germany., Preusser M; Division of Oncology, Department of Medicine I, Medical University of Vienna, Vienna, Austria., Pietsch T; Institute of Neuropathology, DGNN Brain Tumor Reference Center, University of Bonn Medical Center, Bonn, Germany., Prinz M; Institute of Neuropathology, Faculty of Medicine, University of Freiburg, Freiburg, Germany; Signalling Research Centres BIOSS and CIBSS, University of Freiburg, Freiburg, Germany., Reifenberger G; Institute of Neuropathology, Medical Faculty, and University Hospital Düsseldorf, Heinrich Heine University, and German Cancer Consortium (DKTK), Partner Site Essen/Düsseldorf, Düsseldorf, Germany., Kristensen BW; Department of Clinical Medicine and Biotech Research and Innovation Center (BRIC), University of Copenhagen, Copenhagen, Denmark; Department of Pathology, The Bartholin Institute, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark., Kool M; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany; National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands; University Medical Center Utrecht, Utrecht, the Netherlands., Hovestadt V; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA; Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Ellison DW; Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA., Jacques TS; Geoffrey Jefferson Brain Research Centre, Division of Neuroscience, School of Biology, University of Manchester, Manchester, UK., Varlet P; Department of Neuropathology, GHU Paris Psychiatry and Neurosciences, Sainte-Anne Hospital, Paris, France., Etminan N; Department of Neurosurgery, University Hospital Mannheim, Mannheim, Germany., Acker T; Institute of Neuropathology, University of Giessen, Giessen, Germany., Weller M; Department of Neurology, Clinical Neuroscience Center, University Hospital and University of Zurich, Zurich, Switzerland., White CL; Victorian Clinical Genetics Services, Parkville, VIC, Australia., Witt O; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ) and German Consortium for Translational Cancer Research (DKTK), Heidelberg, Germany; Department of Pediatric Oncology, Hematology, Immunology and Pulmonology, University Hospital Heidelberg, Heidelberg, Germany., Herold-Mende C; Division of Experimental Neurosurgery, Department of Neurosurgery, University of Heidelberg, Medical Faculty Heidelberg, Heidelberg, Germany., Debus J; National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany; Heidelberg Institute for Radiation Oncology (HIRO) and National Center for Research in Radiation Oncology (NCRO), Heidelberg, Germany; Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany; Clinical Cooperation Unit Radiation Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany., Krieg S; Department of Neurosurgery, Heidelberg University, Heidelberg, Germany., Wick W; Department of Neurology, University Hospital Heidelberg, Heidelberg, Germany; Clinical Cooperation Unit Neurooncology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany., Snuderl M; Department of Pathology NYU Langone Health and NYU Grossman School of Medicine, New York, NY, USA., Aldape K; Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA., Brandner S; Division of Neuropathology, National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, London, UK; Department of Neurodegenerative Disease, University College London, Institute of Neurology, London, UK., Hawkins C; The Arthur and Sonia Labatt Brain Tumor Research Center, The Hospital for Sick Children, Toronto, ON, Canada; Division of Cell Biology, The Hospital for Sick Children, Toronto, ON, Canada; Division of Pathology, Hospital for Sick Children, Toronto, ON, Canada., Horbinski C; Department of Pathology, Northwestern University, Chicago, IL, USA., Thomas C; Institute of Neuropathology, University Hospital Münster, Münster, Germany., Wesseling P; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA; Department of Pathology, Amsterdam University Medical Centers/VUmc, Amsterdam, the Netherlands., von Deimling A; Department of Neuropathology, University Hospital Heidelberg, Heidelberg, Germany; Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany., Capper D; Department of Neuropathology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany; German Cancer Consortium (DKTK), Partner Site Berlin, German Cancer Research Center (DKFZ), Heidelberg, Germany., Pfister SM; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany; Department of Pediatric Oncology, Hematology, Immunology and Pulmonology, University Hospital Heidelberg, Heidelberg, Germany; National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany., Jones DTW; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany; Division of Pediatric Glioma Research, German Cancer Research Center (DKFZ), Heidelberg, Germany. Electronic address: david.jones@kitz-heidelberg.de., Sahm F; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany; Department of Neuropathology, University Hospital Heidelberg, Heidelberg, Germany; Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany. Electronic address: felix.sahm@med.uni-heidelberg.de.
Source: Cancer cell [Cancer Cell] 2026 Feb 09; Vol. 44 (2), pp. 340-354.e2. Date of Electronic Publication: 2025 Dec 04.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101130617 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-3686 (Electronic) Linking ISSN: 15356108 NLM ISO Abbreviation: Cancer Cell Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Advancing CNS tumor diagnostics with expanded DNA methylation-based classification.
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  Data: <searchLink fieldCode="AU" term="%22Sill+M%22">Sill M</searchLink>; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany. Electronic address: m.sill@kitz-heidelberg.de.<br /><searchLink fieldCode="AU" term="%22Schrimpf+D%22">Schrimpf D</searchLink>; Department of Neuropathology, University Hospital Heidelberg, Heidelberg, Germany; Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Patel+A%22">Patel A</searchLink>; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany; Department of Neuropathology, University Hospital Heidelberg, Heidelberg, Germany; Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Sturm+D%22">Sturm D</searchLink>; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany; Division of Pediatric Glioma Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Jäger+N%22">Jäger N</searchLink>; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Sievers+P%22">Sievers P</searchLink>; Department of Neuropathology, University Hospital Heidelberg, Heidelberg, Germany; Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Schweizer+L%22">Schweizer L</searchLink>; Institute of Neurology (Edinger Institute), University Hospital Frankfurt, Goethe University, Frankfurt am Main, Germany; German Cancer Consortium (DKTK), Partner Site Frankfurt/Mainz, German Cancer Research Center (DKFZ), Heidelberg, Germany; Frankfurt Cancer Institute (FCI), Frankfurt am Main, Germany.<br /><searchLink fieldCode="AU" term="%22Banan+R%22">Banan R</searchLink>; Department of Neuropathology, University Hospital Heidelberg, Heidelberg, Germany; Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Reuss+D%22">Reuss D</searchLink>; Department of Neuropathology, University Hospital Heidelberg, Heidelberg, Germany; Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Suwala+A%22">Suwala A</searchLink>; Department of Neuropathology, University Hospital Heidelberg, Heidelberg, Germany; Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Korshunov+A%22">Korshunov A</searchLink>; Department of Neuropathology, University Hospital Heidelberg, Heidelberg, Germany; Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Stichel+D%22">Stichel D</searchLink>; Department of Neuropathology, University Hospital Heidelberg, Heidelberg, Germany; Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Wefers+AK%22">Wefers AK</searchLink>; Department of Neuropathology, Regensburg University Hospital, Regensburg, Germany; Mildred Scheel Cancer Career Center HaTriCS4, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Hau+AC%22">Hau AC</searchLink>; Translational Neuro-Oncology Group, Dr. Senckenbergisches Institute for Neurooncology and Institute of Neurology (Edinger Institute), University Hospital, Goethe University Frankfurt am Main, Frankfurt am Main, Germany.<br /><searchLink fieldCode="AU" term="%22Boldt+H%22">Boldt H</searchLink>; Department of Pathology, Odense University Hospital, Odense, Denmark.<br /><searchLink fieldCode="AU" term="%22Harter+PN%22">Harter PN</searchLink>; Bavarian Cancer Research Center (BZKF), Partner Site Munich, Munich, Germany; German Cancer Consortium (DKTK), Partner Site Munich, a partnership between DKFZ and University/University Hospital, LMU Munich, Munich, Germany; Center for Neuropathology and Prion Research, Faculty of Medicine, LMU Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Abdullaev+Z%22">Abdullaev Z</searchLink>; Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Benhamida+J%22">Benhamida J</searchLink>; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York City, NY, USA.<br /><searchLink fieldCode="AU" term="%22Teichmann+D%22">Teichmann D</searchLink>; Department of Neuropathology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany; German Cancer Consortium (DKTK), Partner Site Berlin, German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Koch+A%22">Koch A</searchLink>; Department of Neuropathology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany; German Cancer Consortium (DKTK), Partner Site Berlin, German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Hench+J%22">Hench J</searchLink>; Department of Neuropathology, Institute of Pathology, Basel University Hospital, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Frank+S%22">Frank S</searchLink>; Department of Neuropathology, Institute of Pathology, Basel University Hospital, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Hasselblatt+M%22">Hasselblatt M</searchLink>; Institute of Neuropathology, University Hospital Münster, Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Mansouri+S%22">Mansouri S</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada; MacFeeters Hamilton Neuro-Oncology Program, Princess Margaret Cancer Centre, University Health Network and University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Díaz+de+Ståhl+T%22">Díaz de Ståhl T</searchLink>; Department of Oncology-Pathology, Karolinska Institute, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Serrano+J%22">Serrano J</searchLink>; Department of Pathology NYU Langone Health and NYU Grossman School of Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Ecker+J%22">Ecker J</searchLink>; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany; KiTZ Clinical Trial Unit, Department of Pediatric Hematology and Oncology, Heidelberg University Hospital, Heidelberg, Germany; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ) and German Consortium for Translational Cancer Research (DKTK), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Selt+F%22">Selt F</searchLink>; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ) and German Consortium for Translational Cancer Research (DKTK), Heidelberg, Germany; Department of Pediatric Oncology, Hematology, Immunology and Pulmonology, University Hospital Heidelberg, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Taylor+M%22">Taylor M</searchLink>; Department of Pediatrics- Hematology/Oncology, and Neurosurgery, Texas Children's Cancer Center, Hematology-Oncology Section, Baylor College of Medicine, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Ramaswamy+V%22">Ramaswamy V</searchLink>; The Arthur and Sonia Labatt Brain Tumor Research Center, The Hospital for Sick Children, Toronto, ON, Canada; Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Cavalli+F%22">Cavalli F</searchLink>; Institut Curie, PSL Research University, Paris, France; Inserm, U900, Paris, France; MINES ParisTech, CBIO, Centre for Computational Biology, PSL Research University, 75006 Paris, France.<br /><searchLink fieldCode="AU" term="%22Berghoff+AS%22">Berghoff AS</searchLink>; Division of Oncology, Department of Medicine I, Medical University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Bison+B%22">Bison B</searchLink>; Department of Diagnostic and Interventional Neuroradiology, Faculty of Medicine, University of Augsburg, Augsburg, Germany.<br /><searchLink fieldCode="AU" term="%22Blattner-Johnson+M%22">Blattner-Johnson M</searchLink>; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany; Division of Pediatric Glioma Research, German Cancer Research Center (DKFZ), Heidelberg, Germany; National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Buchhalter+I%22">Buchhalter I</searchLink>; Omics IT and Data Management Core Facility, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Buslei+R%22">Buslei R</searchLink>; Institute of Pathology, Sozialstiftung Bamberg, Klinikum am Bruderwald, Bamberg, Germany.<br /><searchLink fieldCode="AU" term="%22Calaminus+G%22">Calaminus G</searchLink>; Department of Pediatric Hematology and Oncology, University Hospital Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Dikow+N%22">Dikow N</searchLink>; Institute of Human Genetics, Heidelberg University Hospital, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Dohmen+H%22">Dohmen H</searchLink>; Institute of Neuropathology, University of Giessen, Giessen, Germany.<br /><searchLink fieldCode="AU" term="%22Euskirchen+P%22">Euskirchen P</searchLink>; Department of Neuropathology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany; German Cancer Consortium (DKTK), Partner Site Berlin, German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Fleischhack+G%22">Fleischhack G</searchLink>; Pediatrics III, University Hospital Essen, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Gajjar+A%22">Gajjar A</searchLink>; Division of Neuro Oncology, Department of Oncology, St Jude Children's Research Hospital, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Gerber+NU%22">Gerber NU</searchLink>; Department of Oncology, University Children's Hospital, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Gessi+M%22">Gessi M</searchLink>; Department of Life Sciences and Public Health, Università Cattolica Sacro Cuore, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Gielen+GH%22">Gielen GH</searchLink>; Department of Neuropathology, University Hospital Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Gnekow+A%22">Gnekow A</searchLink>; Swabian Children's Cancer Center, Pediatric and Adolescent Medicine, Faculty of Medicine, University of Augsburg, Augsburg, Germany.<br /><searchLink fieldCode="AU" term="%22Gottardo+NG%22">Gottardo NG</searchLink>; Department of Pediatric and Adolescent Oncology/Haematology, Perth Children's Hospital, Nedlands, WA, Australia; Centre for Child Health Research, University of Western Australia, Nedlands, WA, Australia; Brain Tumour Research Program, Telethon Kids Institute, Nedlands, WA, Australia.<br /><searchLink fieldCode="AU" term="%22Haberler+C%22">Haberler C</searchLink>; Division of Neuropathology and Neurochemistry, Department of Neurology, Medical University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Hamelmann+S%22">Hamelmann S</searchLink>; Department of Neuropathology, University Hospital Heidelberg, Heidelberg, Germany; Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Hans+V%22">Hans V</searchLink>; Department of Neuropathology, Institute for Clinical Pathology, Dietrich-Bonhoeffer-Klinikum, Neubrandenburg, Germany.<br /><searchLink fieldCode="AU" term="%22Hansford+JR%22">Hansford JR</searchLink>; Michael Rice Centre for Hematology and Oncology, Women's and Children's Hospital, South Australia Health and Medical Research Institute, South Australia Immunogenomics Cancer Institute, University of Adelaide, Adelaide, SA, Australia.<br /><searchLink fieldCode="AU" term="%22Hartmann+C%22">Hartmann C</searchLink>; Department of Neuropathology, Institute of Pathology, Hannover Medical School, Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Heppner+FL%22">Heppner FL</searchLink>; Department of Neuropathology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany; German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Driever+PH%22">Driever PH</searchLink>; Charité-Universitätsmedizin Berlin, Corporate member of Freie Universität Berlin and Humboldt-Universität Berlin, German HIT-LOGGIC-Registry for Children and Adolescents with Low-Grade Glioma, Department of Pediatric Oncology and Hematology, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22von+Hoff+K%22">von Hoff K</searchLink>; Department of Pediatric Oncology and Hematology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany; Department of Pediatric and Adolescent Medicine, Aarhus University Hospital, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Thomale+UW%22">Thomale UW</searchLink>; Pediatric Neurosurgery, Charité-Universitätsmedizin Berlin, Campus Virchow Klinikum, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Tippelt+S%22">Tippelt S</searchLink>; Pediatrics III, University Hospital Essen, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Frühwald+MC%22">Frühwald MC</searchLink>; Pediatrics and Adolescent Medicine, Swabian Children's Cancer Center, University Medical Center Augsburg and Bavarian Cancer Research Center/KIONET Bavaria, Augsburg, Bavaria, Germany.<br /><searchLink fieldCode="AU" term="%22Kramm+CM%22">Kramm CM</searchLink>; Division of Pediatric Hematology and Oncology, University Medical Center Göttingen, Göttingen, Germany.<br /><searchLink fieldCode="AU" term="%22Schüller+U%22">Schüller U</searchLink>; Institute of Neuropathology and Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Germany, Research Institute Children's Cancer Center Hamburg, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Schittenhelm+J%22">Schittenhelm J</searchLink>; Institute of Neuropathology, Department of Pathology and Neuropathology, University Hospital Tübingen, Eberhard Karls University Tübingen, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Schuhmann+MU%22">Schuhmann MU</searchLink>; Section of Pediatric Neurosurgery, Department of Neurosurgery, University Hospital Tübingen, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Stein+M%22">Stein M</searchLink>; Department of Neurosurgery, Justus-Liebig University, Giessen, Germany.<br /><searchLink fieldCode="AU" term="%22Ketteler+P%22">Ketteler P</searchLink>; Pediatrics III, University Hospital Essen, Essen, Germany; Institute of Human Genetics, University Duisburg-Essen, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Ladanyi+M%22">Ladanyi M</searchLink>; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York City, NY, USA.<br /><searchLink fieldCode="AU" term="%22Jabado+N%22">Jabado N</searchLink>; Department of Pediatrics, McGill University, and The Research Institute of the McGill University Health Centre, Montreal, QC, Canada; Department of Human Genetics, McGill University, Montreal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Jones+BC%22">Jones BC</searchLink>; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany; Division of Pediatric Glioma Research, German Cancer Research Center (DKFZ), Heidelberg, Germany; Department of Pediatric Oncology, Hematology, Immunology and Pulmonology, University Hospital Heidelberg, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Jones+C%22">Jones C</searchLink>; Division of Molecular Pathology, The Institute of Cancer Research (ICR), Sutton, Surrey, UK.<br /><searchLink fieldCode="AU" term="%22Karajannis+MA%22">Karajannis MA</searchLink>; Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Ketter+R%22">Ketter R</searchLink>; Department of Neurosurgery, Saarland University, Medical School, Homburg, Germany.<br /><searchLink fieldCode="AU" term="%22Kohlhof+P%22">Kohlhof P</searchLink>; Department for Pathology, Katharinenhospital Stuttgart, Stuttgart, Germany.<br /><searchLink fieldCode="AU" term="%22Kordes+U%22">Kordes U</searchLink>; Department of Pediatric Hematology/Oncology, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Reinhardt+A%22">Reinhardt A</searchLink>; Department of Neuropathology, University Hospital Heidelberg, Heidelberg, Germany; Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Kölsche+C%22">Kölsche C</searchLink>; Institute of Pathology, LMU Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Lamszus+K%22">Lamszus K</searchLink>; Department of Neurosurgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Lichter+P%22">Lichter P</searchLink>; National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany; Division of Molecular Genetics, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Maas+SLN%22">Maas SLN</searchLink>; Department of Pathology, Leiden University Medical Center, Leiden, the Netherlands; Department of Pathology, Erasmus MC Cancer Institute, University Medical Center Rotterdam, Rotterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Mawrin+C%22">Mawrin C</searchLink>; Department of Neuropathology, Otto von Guericke University, Magdeburg, Germany.<br /><searchLink fieldCode="AU" term="%22Milde+T%22">Milde T</searchLink>; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ) and German Consortium for Translational Cancer Research (DKTK), Heidelberg, Germany; Department of Pediatrics, Jena University Hospital and Comprehensive Cancer Center Central Germany (CCCG), Jena, Germany.<br /><searchLink fieldCode="AU" term="%22Mittelbronn+M%22">Mittelbronn M</searchLink>; Luxembourg National Center of Pathology (NCP), Laboratoire National de Santé (LNS), Department of Cancer Research (DOCR), Luxembourg Institute of Health (LIH), Luxembourg Centre of Neuropathology (LCNP), Luxembourg Centre for Systems Biomedicine (LCSB), Faculty of Science, Technology and Medicine (FSTM) and Department of Life Sciences and Medicine (DLSM), University of Luxembourg, Esch-sur-Alzette, Luxembourg.<br /><searchLink fieldCode="AU" term="%22Monoranu+CM%22">Monoranu CM</searchLink>; Institute of Pathology, Department of Neuropathology, University of Würzburg, Würzburg, Germany.<br /><searchLink fieldCode="AU" term="%22Mueller+W%22">Mueller W</searchLink>; Department of Neuropathology, University of Leipzig, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Mynarek+M%22">Mynarek M</searchLink>; Mildred Scheel Cancer Career Center HaTriCS4, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Department of Pediatric Hematology/Oncology, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Northcott+PA%22">Northcott PA</searchLink>; Center of Excellence in Neuro-Oncology Sciences, St. Jude Children's Research Hospital, Memphis, TN, USA; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Pajtler+KW%22">Pajtler KW</searchLink>; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany; Department of Pediatric Oncology, Hematology, Immunology and Pulmonology, University Hospital Heidelberg, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Paulus+W%22">Paulus W</searchLink>; Institute of Neuropathology, University Hospital Münster, Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Perry+A%22">Perry A</searchLink>; Departments of Pathology and Neurological Surgery, UCSF, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Blümcke+I%22">Blümcke I</searchLink>; Department of Neuropathology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Partner of the European Reference Network (ERN) EpiCARE, Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Plate+KH%22">Plate KH</searchLink>; Institute of Neurology (Edinger Institute), University Hospital Frankfurt, Goethe University, Frankfurt am Main, Germany; German Cancer Consortium (DKTK), Partner Site Frankfurt/Mainz, German Cancer Research Center (DKFZ), Heidelberg, Germany; Frankfurt Cancer Institute (FCI), Frankfurt am Main, Germany.<br /><searchLink fieldCode="AU" term="%22Platten+M%22">Platten M</searchLink>; National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany; Clinical Cooperation Unit (CCU) Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany; Department of Neurology, Medical Faculty Mannheim, Mannheim Center for Translation Neuroscience (MCTN), Heidelberg University, Mannheim, Germany; Helmholtz Institute for Translational Oncology Mainz (HI-TRON Mainz) - A Helmholtz Institute of the DKFZ, Mainz, Germany; DKFZ Hector Cancer Institute at the University Medical Center Mannheim, Mannheim, Germany.<br /><searchLink fieldCode="AU" term="%22Preusser+M%22">Preusser M</searchLink>; Division of Oncology, Department of Medicine I, Medical University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Pietsch+T%22">Pietsch T</searchLink>; Institute of Neuropathology, DGNN Brain Tumor Reference Center, University of Bonn Medical Center, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Prinz+M%22">Prinz M</searchLink>; Institute of Neuropathology, Faculty of Medicine, University of Freiburg, Freiburg, Germany; Signalling Research Centres BIOSS and CIBSS, University of Freiburg, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Reifenberger+G%22">Reifenberger G</searchLink>; Institute of Neuropathology, Medical Faculty, and University Hospital Düsseldorf, Heinrich Heine University, and German Cancer Consortium (DKTK), Partner Site Essen/Düsseldorf, Düsseldorf, Germany.<br /><searchLink fieldCode="AU" term="%22Kristensen+BW%22">Kristensen BW</searchLink>; Department of Clinical Medicine and Biotech Research and Innovation Center (BRIC), University of Copenhagen, Copenhagen, Denmark; Department of Pathology, The Bartholin Institute, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Kool+M%22">Kool M</searchLink>; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany; National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands; University Medical Center Utrecht, Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Hovestadt+V%22">Hovestadt V</searchLink>; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA; Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Ellison+DW%22">Ellison DW</searchLink>; Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Jacques+TS%22">Jacques TS</searchLink>; Geoffrey Jefferson Brain Research Centre, Division of Neuroscience, School of Biology, University of Manchester, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Varlet+P%22">Varlet P</searchLink>; Department of Neuropathology, GHU Paris Psychiatry and Neurosciences, Sainte-Anne Hospital, Paris, France.<br /><searchLink fieldCode="AU" term="%22Etminan+N%22">Etminan N</searchLink>; Department of Neurosurgery, University Hospital Mannheim, Mannheim, Germany.<br /><searchLink fieldCode="AU" term="%22Acker+T%22">Acker T</searchLink>; Institute of Neuropathology, University of Giessen, Giessen, Germany.<br /><searchLink fieldCode="AU" term="%22Weller+M%22">Weller M</searchLink>; Department of Neurology, Clinical Neuroscience Center, University Hospital and University of Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22White+CL%22">White CL</searchLink>; Victorian Clinical Genetics Services, Parkville, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Witt+O%22">Witt O</searchLink>; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ) and German Consortium for Translational Cancer Research (DKTK), Heidelberg, Germany; Department of Pediatric Oncology, Hematology, Immunology and Pulmonology, University Hospital Heidelberg, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Herold-Mende+C%22">Herold-Mende C</searchLink>; Division of Experimental Neurosurgery, Department of Neurosurgery, University of Heidelberg, Medical Faculty Heidelberg, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Debus+J%22">Debus J</searchLink>; National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany; Heidelberg Institute for Radiation Oncology (HIRO) and National Center for Research in Radiation Oncology (NCRO), Heidelberg, Germany; Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany; Clinical Cooperation Unit Radiation Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Krieg+S%22">Krieg S</searchLink>; Department of Neurosurgery, Heidelberg University, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Wick+W%22">Wick W</searchLink>; Department of Neurology, University Hospital Heidelberg, Heidelberg, Germany; Clinical Cooperation Unit Neurooncology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Snuderl+M%22">Snuderl M</searchLink>; Department of Pathology NYU Langone Health and NYU Grossman School of Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Aldape+K%22">Aldape K</searchLink>; Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Brandner+S%22">Brandner S</searchLink>; Division of Neuropathology, National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, London, UK; Department of Neurodegenerative Disease, University College London, Institute of Neurology, London, UK.<br /><searchLink fieldCode="AU" term="%22Hawkins+C%22">Hawkins C</searchLink>; The Arthur and Sonia Labatt Brain Tumor Research Center, The Hospital for Sick Children, Toronto, ON, Canada; Division of Cell Biology, The Hospital for Sick Children, Toronto, ON, Canada; Division of Pathology, Hospital for Sick Children, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Horbinski+C%22">Horbinski C</searchLink>; Department of Pathology, Northwestern University, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Thomas+C%22">Thomas C</searchLink>; Institute of Neuropathology, University Hospital Münster, Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Wesseling+P%22">Wesseling P</searchLink>; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA; Department of Pathology, Amsterdam University Medical Centers/VUmc, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22von+Deimling+A%22">von Deimling A</searchLink>; Department of Neuropathology, University Hospital Heidelberg, Heidelberg, Germany; Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Capper+D%22">Capper D</searchLink>; Department of Neuropathology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany; German Cancer Consortium (DKTK), Partner Site Berlin, German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Pfister+SM%22">Pfister SM</searchLink>; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany; Department of Pediatric Oncology, Hematology, Immunology and Pulmonology, University Hospital Heidelberg, Heidelberg, Germany; National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Jones+DTW%22">Jones DTW</searchLink>; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany; Division of Pediatric Glioma Research, German Cancer Research Center (DKFZ), Heidelberg, Germany. Electronic address: david.jones@kitz-heidelberg.de.<br /><searchLink fieldCode="AU" term="%22Sahm+F%22">Sahm F</searchLink>; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany; Department of Neuropathology, University Hospital Heidelberg, Heidelberg, Germany; Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany. Electronic address: felix.sahm@med.uni-heidelberg.de.
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  Data: <searchLink fieldCode="JN" term="%22101130617%22">Cancer cell</searchLink> [Cancer Cell] 2026 Feb 09; Vol. 44 (2), pp. 340-354.e2. <i>Date of Electronic Publication: </i>2025 Dec 04.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Cell+Press%22">Cell Press </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101130617 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1878-3686 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2215356108%22">15356108 </searchLink><i>NLM ISO Abbreviation: </i>Cancer Cell <i>Subsets: </i>MEDLINE
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      – TitleFull: Advancing CNS tumor diagnostics with expanded DNA methylation-based classification.
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      – PersonEntity:
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      – PersonEntity:
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      – PersonEntity:
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      – PersonEntity:
          Name:
            NameFull: Horbinski C
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      – PersonEntity:
          Name:
            NameFull: Wesseling P
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      – PersonEntity:
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            NameFull: Capper D
      – PersonEntity:
          Name:
            NameFull: Pfister SM
      – PersonEntity:
          Name:
            NameFull: Jones DTW
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          Name:
            NameFull: Sahm F
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 09
              M: 02
              Text: 2026 Feb 09
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 1878-3686
          Numbering:
            – Type: volume
              Value: 44
            – Type: issue
              Value: 2
          Titles:
            – TitleFull: Cancer cell
              Type: main
ResultId 1