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Unique molecular architecture of N-glycosylated TM4SF5 dimer highlights evolutionary and structural divergence among small four-transmembrane protein families.

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Title: Unique molecular architecture of N-glycosylated TM4SF5 dimer highlights evolutionary and structural divergence among small four-transmembrane protein families.
Authors: Lee Y; College of Pharmacy, Chung-Ang University, Seoul 06974, the Republic of Korea. Electronic address: yoonjilee@cau.ac.kr., Kim JE; Department of Pharmacy, Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, the Republic of Korea; Department of Integrative Bioscience & Biotechnology, Sejong University, Seoul 05006, the Republic of Korea., Kim W; Department of Pharmacy, Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, the Republic of Korea., Kim S; Department of Pharmacy, Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, the Republic of Korea., Han R; College of Pharmacy, Chung-Ang University, Seoul 06974, the Republic of Korea., Suh D; Global AI Drug Discovery Center, College of Pharmacy and Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul 03760, the Republic of Korea., Kim E; Department of Pharmacy, Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, the Republic of Korea., Shin EA; Department of Pharmacy, Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, the Republic of Korea., Pyo KH; Department of Pharmacy, Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, the Republic of Korea., Lee JH; Department of Pharmacy, Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, the Republic of Korea., Yoon S; Global AI Drug Discovery Center, College of Pharmacy and Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul 03760, the Republic of Korea., Kim YI; Department of Biochemistry, College of Veterinary Medicine, Seoul National University, Seoul 08826, the Republic of Korea., Cho JY; Department of Biochemistry, College of Veterinary Medicine, Seoul National University, Seoul 08826, the Republic of Korea., Choi S; Global AI Drug Discovery Center, College of Pharmacy and Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul 03760, the Republic of Korea. Electronic address: sunchoi@ewha.ac.kr., Lee JW; Department of Pharmacy, Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, the Republic of Korea. Electronic address: jwl@snu.ac.kr.
Source: Journal of advanced research [J Adv Res] 2025 Dec 03. Date of Electronic Publication: 2025 Dec 03.
Publication Type: Journal Article
Journal Info: Publisher: Cairo University, production and hosting by Elsevier B. V Country of Publication: Egypt NLM ID: 101546952 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2090-1224 (Electronic) Linking ISSN: 20901224 NLM ISO Abbreviation: J Adv Res Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Lee+Y%22">Lee Y</searchLink>; College of Pharmacy, Chung-Ang University, Seoul 06974, the Republic of Korea. Electronic address: yoonjilee@cau.ac.kr.<br /><searchLink fieldCode="AU" term="%22Kim+JE%22">Kim JE</searchLink>; Department of Pharmacy, Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, the Republic of Korea; Department of Integrative Bioscience & Biotechnology, Sejong University, Seoul 05006, the Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kim+W%22">Kim W</searchLink>; Department of Pharmacy, Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, the Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kim+S%22">Kim S</searchLink>; Department of Pharmacy, Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, the Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Han+R%22">Han R</searchLink>; College of Pharmacy, Chung-Ang University, Seoul 06974, the Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Suh+D%22">Suh D</searchLink>; Global AI Drug Discovery Center, College of Pharmacy and Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul 03760, the Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kim+E%22">Kim E</searchLink>; Department of Pharmacy, Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, the Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Shin+EA%22">Shin EA</searchLink>; Department of Pharmacy, Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, the Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Pyo+KH%22">Pyo KH</searchLink>; Department of Pharmacy, Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, the Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Lee+JH%22">Lee JH</searchLink>; Department of Pharmacy, Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, the Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Yoon+S%22">Yoon S</searchLink>; Global AI Drug Discovery Center, College of Pharmacy and Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul 03760, the Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kim+YI%22">Kim YI</searchLink>; Department of Biochemistry, College of Veterinary Medicine, Seoul National University, Seoul 08826, the Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Cho+JY%22">Cho JY</searchLink>; Department of Biochemistry, College of Veterinary Medicine, Seoul National University, Seoul 08826, the Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Choi+S%22">Choi S</searchLink>; Global AI Drug Discovery Center, College of Pharmacy and Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul 03760, the Republic of Korea. Electronic address: sunchoi@ewha.ac.kr.<br /><searchLink fieldCode="AU" term="%22Lee+JW%22">Lee JW</searchLink>; Department of Pharmacy, Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, the Republic of Korea. Electronic address: jwl@snu.ac.kr.
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              Text: 2025 Dec 03
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