Effects of finerenone on arterial stiffness and cardiorenal biomarkers in patients with type 2 diabetes and chronic kidney disease: a randomised placebo-controlled mechanistic trial (FIVE-STAR).
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| Title: | Effects of finerenone on arterial stiffness and cardiorenal biomarkers in patients with type 2 diabetes and chronic kidney disease: a randomised placebo-controlled mechanistic trial (FIVE-STAR). |
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| Authors: | Tanaka A; Department of Cardiovascular Medicine, Saga University, Saga, Japan. tanakaa2@cc.saga-u.ac.jp., Vaduganathan M; Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Imai T; Clinical Research Division, Organization for Clinical Medicine Promotion, Tokyo, Japan.; Clinical and Translational Research Center, Kobe University Hospital, Kobe, Japan., Okada Y; Clinical Research Center, Hospital of the University of Occupational and Environmental Health, Kitakyushu, Japan., Sonoda S; First Department of Internal Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan., Torimoto K; First Department of Internal Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan., Suwa S; Department of Cardiology, Juntendo University Shizuoka Hospital, Izunokuni, Japan., Teragawa H; Department of Cardiovascular Medicine, JR Hiroshima Hospital, Hiroshima, Japan., Miyazono M; Department of Nephrology, Saga University, Saga, Japan., Fukuda M; Department of Nephrology, Saga University, Saga, Japan., Yonezu K; Department of Cardiology and Clinical Examination, Faculty of Medicine, Oita University, Yufu, Japan., Takahashi N; Department of Cardiology and Clinical Examination, Faculty of Medicine, Oita University, Yufu, Japan., Yoshida Y; Department of Endocrinology, Rheumatology and Nephrology, Faculty of Medicine, Oita University, Metabolism, Yufu, Japan., Tanaka K; Wakamatsu Hospital of the University of Occupational and Environmental Health, Kitakyushu, Japan., Shimabukuro M; Department of Diabetes, Endocrinology, and Metabolism, Fukushima Medical University School of Medicine, Fukushima, Japan., Hotta Y; Department of Diabetes, Endocrinology, and Metabolism, Fukushima Medical University School of Medicine, Fukushima, Japan., Moroi M; Division of Cardiovascular Medicine, Toho University Ohashi Medical Center, Tokyo, Japan., Niikura H; Division of Cardiovascular Medicine, Toho University Ohashi Medical Center, Tokyo, Japan., Kida K; Department of Pharmacology, St. Marianna University School of Medicine, Kawasaki, Japan., Yokota K; Division of Metabolism and Endocrinology, Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Japan., Fukuda D; Department of Cardiovascular Medicine, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan., Tanabe K; Division of Cardiology, Mitsui Memorial Hospital, Tokyo, Japan., Horiuchi Y; Division of Cardiology, Mitsui Memorial Hospital, Tokyo, Japan., Toyoda S; Department of Cardiovascular Medicine, Dokkyo Medical University, Mibu, Japan., Taguchi I; Department of Cardiology, Dokkyo Medical University Saitama Medical Center, Koshigaya, Japan., Yoshida H; Department of Medical Statistics, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan., Miyoshi T; Department of Cardiovascular Medicine, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Okayama, Japan., Nangaku M; Division of Nephrology and Endocrinology, The University of Tokyo Graduate School of Medicine, Tokyo, Japan., Shibata H; Department of Endocrinology, Rheumatology and Nephrology, Faculty of Medicine, Oita University, Metabolism, Yufu, Japan., Node K; Department of Cardiovascular Medicine, Saga University, Saga, Japan. node@cc.saga-u.ac.jp. |
| Corporate Authors: | FIVE-STAR Investigators |
| Source: | Cardiovascular diabetology [Cardiovasc Diabetol] 2025 Dec 05; Vol. 24 (1), pp. 454. Date of Electronic Publication: 2025 Dec 05. |
| Publication Type: | Journal Article; Randomized Controlled Trial; Multicenter Study |
| Journal Info: | Publisher: BioMed Central Country of Publication: England NLM ID: 101147637 Publication Model: Electronic Cited Medium: Internet ISSN: 1475-2840 (Electronic) Linking ISSN: 14752840 NLM ISO Abbreviation: Cardiovasc Diabetol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41351003 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Effects of finerenone on arterial stiffness and cardiorenal biomarkers in patients with type 2 diabetes and chronic kidney disease: a randomised placebo-controlled mechanistic trial (FIVE-STAR). – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Tanaka+A%22">Tanaka A</searchLink>; Department of Cardiovascular Medicine, Saga University, Saga, Japan. tanakaa2@cc.saga-u.ac.jp.<br /><searchLink fieldCode="AU" term="%22Vaduganathan+M%22">Vaduganathan M</searchLink>; Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Imai+T%22">Imai T</searchLink>; Clinical Research Division, Organization for Clinical Medicine Promotion, Tokyo, Japan.; Clinical and Translational Research Center, Kobe University Hospital, Kobe, Japan.<br /><searchLink fieldCode="AU" term="%22Okada+Y%22">Okada Y</searchLink>; Clinical Research Center, Hospital of the University of Occupational and Environmental Health, Kitakyushu, Japan.<br /><searchLink fieldCode="AU" term="%22Sonoda+S%22">Sonoda S</searchLink>; First Department of Internal Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.<br /><searchLink fieldCode="AU" term="%22Torimoto+K%22">Torimoto K</searchLink>; First Department of Internal Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.<br /><searchLink fieldCode="AU" term="%22Suwa+S%22">Suwa S</searchLink>; Department of Cardiology, Juntendo University Shizuoka Hospital, Izunokuni, Japan.<br /><searchLink fieldCode="AU" term="%22Teragawa+H%22">Teragawa H</searchLink>; Department of Cardiovascular Medicine, JR Hiroshima Hospital, Hiroshima, Japan.<br /><searchLink fieldCode="AU" term="%22Miyazono+M%22">Miyazono M</searchLink>; Department of Nephrology, Saga University, Saga, Japan.<br /><searchLink fieldCode="AU" term="%22Fukuda+M%22">Fukuda M</searchLink>; Department of Nephrology, Saga University, Saga, Japan.<br /><searchLink fieldCode="AU" term="%22Yonezu+K%22">Yonezu K</searchLink>; Department of Cardiology and Clinical Examination, Faculty of Medicine, Oita University, Yufu, Japan.<br /><searchLink fieldCode="AU" term="%22Takahashi+N%22">Takahashi N</searchLink>; Department of Cardiology and Clinical Examination, Faculty of Medicine, Oita University, Yufu, Japan.<br /><searchLink fieldCode="AU" term="%22Yoshida+Y%22">Yoshida Y</searchLink>; Department of Endocrinology, Rheumatology and Nephrology, Faculty of Medicine, Oita University, Metabolism, Yufu, Japan.<br /><searchLink fieldCode="AU" term="%22Tanaka+K%22">Tanaka K</searchLink>; Wakamatsu Hospital of the University of Occupational and Environmental Health, Kitakyushu, Japan.<br /><searchLink fieldCode="AU" term="%22Shimabukuro+M%22">Shimabukuro M</searchLink>; Department of Diabetes, Endocrinology, and Metabolism, Fukushima Medical University School of Medicine, Fukushima, Japan.<br /><searchLink fieldCode="AU" term="%22Hotta+Y%22">Hotta Y</searchLink>; Department of Diabetes, Endocrinology, and Metabolism, Fukushima Medical University School of Medicine, Fukushima, Japan.<br /><searchLink fieldCode="AU" term="%22Moroi+M%22">Moroi M</searchLink>; Division of Cardiovascular Medicine, Toho University Ohashi Medical Center, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Niikura+H%22">Niikura H</searchLink>; Division of Cardiovascular Medicine, Toho University Ohashi Medical Center, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Kida+K%22">Kida K</searchLink>; Department of Pharmacology, St. Marianna University School of Medicine, Kawasaki, Japan.<br /><searchLink fieldCode="AU" term="%22Yokota+K%22">Yokota K</searchLink>; Division of Metabolism and Endocrinology, Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Japan.<br /><searchLink fieldCode="AU" term="%22Fukuda+D%22">Fukuda D</searchLink>; Department of Cardiovascular Medicine, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Tanabe+K%22">Tanabe K</searchLink>; Division of Cardiology, Mitsui Memorial Hospital, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Horiuchi+Y%22">Horiuchi Y</searchLink>; Division of Cardiology, Mitsui Memorial Hospital, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Toyoda+S%22">Toyoda S</searchLink>; Department of Cardiovascular Medicine, Dokkyo Medical University, Mibu, Japan.<br /><searchLink fieldCode="AU" term="%22Taguchi+I%22">Taguchi I</searchLink>; Department of Cardiology, Dokkyo Medical University Saitama Medical Center, Koshigaya, Japan.<br /><searchLink fieldCode="AU" term="%22Yoshida+H%22">Yoshida H</searchLink>; Department of Medical Statistics, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Miyoshi+T%22">Miyoshi T</searchLink>; Department of Cardiovascular Medicine, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Okayama, Japan.<br /><searchLink fieldCode="AU" term="%22Nangaku+M%22">Nangaku M</searchLink>; Division of Nephrology and Endocrinology, The University of Tokyo Graduate School of Medicine, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Shibata+H%22">Shibata H</searchLink>; Department of Endocrinology, Rheumatology and Nephrology, Faculty of Medicine, Oita University, Metabolism, Yufu, Japan.<br /><searchLink fieldCode="AU" term="%22Node+K%22">Node K</searchLink>; Department of Cardiovascular Medicine, Saga University, Saga, Japan. node@cc.saga-u.ac.jp. – Name: AuthorCorporate Label: Corporate Authors Group: Au Data: <searchLink fieldCode="CA" term="%22FIVE-STAR+Investigators%22">FIVE-STAR Investigators</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101147637%22">Cardiovascular diabetology</searchLink> [Cardiovasc Diabetol] 2025 Dec 05; Vol. 24 (1), pp. 454. <i>Date of Electronic Publication: </i>2025 Dec 05. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Randomized Controlled Trial; Multicenter Study – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101147637 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1475-2840 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2214752840%22">14752840 </searchLink><i>NLM ISO Abbreviation: </i>Cardiovasc Diabetol <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41351003 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1186/s12933-025-03014-x Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 454 Titles: – TitleFull: Effects of finerenone on arterial stiffness and cardiorenal biomarkers in patients with type 2 diabetes and chronic kidney disease: a randomised placebo-controlled mechanistic trial (FIVE-STAR). Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Tanaka A – PersonEntity: Name: NameFull: Vaduganathan M – PersonEntity: Name: NameFull: Imai T – PersonEntity: Name: NameFull: Okada Y – PersonEntity: Name: NameFull: Sonoda S – PersonEntity: Name: NameFull: Torimoto K – PersonEntity: Name: NameFull: Suwa S – PersonEntity: Name: NameFull: Teragawa H – PersonEntity: Name: NameFull: Miyazono M – PersonEntity: Name: NameFull: Fukuda M – PersonEntity: Name: NameFull: Yonezu K – PersonEntity: Name: NameFull: Takahashi N – PersonEntity: Name: NameFull: Yoshida Y – PersonEntity: Name: NameFull: Tanaka K – PersonEntity: Name: NameFull: Shimabukuro M – PersonEntity: Name: NameFull: Hotta Y – PersonEntity: Name: NameFull: Moroi M – PersonEntity: Name: NameFull: Niikura H – PersonEntity: Name: NameFull: Kida K – PersonEntity: Name: NameFull: Yokota K – PersonEntity: Name: NameFull: Fukuda D – PersonEntity: Name: NameFull: Tanabe K – PersonEntity: Name: NameFull: Horiuchi Y – PersonEntity: Name: NameFull: Toyoda S – PersonEntity: Name: NameFull: Taguchi I – PersonEntity: Name: NameFull: Yoshida H – PersonEntity: Name: NameFull: Miyoshi T – PersonEntity: Name: NameFull: Nangaku M – PersonEntity: Name: NameFull: Shibata H – PersonEntity: Name: NameFull: Node K IsPartOfRelationships: – BibEntity: Dates: – D: 05 M: 12 Text: 2025 Dec 05 Type: published Y: 2025 Identifiers: – Type: issn-electronic Value: 1475-2840 Numbering: – Type: volume Value: 24 – Type: issue Value: 1 Titles: – TitleFull: Cardiovascular diabetology Type: main |
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