Therapeutic 6-thio-deoxyguanosine inhibits telomere elongation in cancer cells by inducing a non-productive stalled telomerase complex.
Saved in:
| Title: | Therapeutic 6-thio-deoxyguanosine inhibits telomere elongation in cancer cells by inducing a non-productive stalled telomerase complex. |
|---|---|
| Authors: | Sanford SL; UPMC Hillman Cancer Center, Pittsburgh, PA, USA., Badstübner M; Department of Chemistry and Biochemistry, University of California, Santa Cruz, Santa Cruz, CA, USA., Gerber M; UPMC Hillman Cancer Center, Pittsburgh, PA, USA., Mannherz W; Division of Hematology/Oncology and Stem Cell Program, Boston Children's Hospital, Boston, MA, USA.; Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Biological and Biomedical Sciences Program, Harvard/MIT MD-PhD Program, Harvard Stem Cell Institute, Harvard Initiative for RNA Medicine, and Department of Pediatrics, Harvard Medical School, Boston, MA, USA., Lampl N; Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Biological and Biomedical Sciences Program, Harvard/MIT MD-PhD Program, Harvard Stem Cell Institute, Harvard Initiative for RNA Medicine, and Department of Pediatrics, Harvard Medical School, Boston, MA, USA., Dannenberg R; Department of Chemistry, The Pennsylvania State University, University Park, PA, USA., Hinchie A; Dorothy P. and Richard P. Simmons Center for Interstitial Lung Disease, University of Pittsburgh, Pittsburgh, PA, USA.; Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Schaich MA; UPMC Hillman Cancer Center, Pittsburgh, PA, USA.; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Myong S; Program in Cell, Molecular, Developmental Biology and Biophysics, Johns Hopkins University, Baltimore, MD, USA.; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, 02115, USA., Hedglin M; Department of Chemistry, The Pennsylvania State University, University Park, PA, USA., Agarwal S; Division of Hematology/Oncology and Stem Cell Program, Boston Children's Hospital, Boston, MA, USA.; Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Biological and Biomedical Sciences Program, Harvard/MIT MD-PhD Program, Harvard Stem Cell Institute, Harvard Initiative for RNA Medicine, and Department of Pediatrics, Harvard Medical School, Boston, MA, USA., Alder JK; Dorothy P. and Richard P. Simmons Center for Interstitial Lung Disease, University of Pittsburgh, Pittsburgh, PA, USA.; Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Stone MD; Department of Chemistry and Biochemistry, University of California, Santa Cruz, Santa Cruz, CA, USA.; RNA Center, University of California Santa Cruz, Santa Cruz, CA, USA., Opresko PL; UPMC Hillman Cancer Center, Pittsburgh, PA, USA. plo4@pitt.edu.; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. plo4@pitt.edu.; Department of Environmental and Occupational Health, University of Pittsburgh School of Public Health, Pittsburgh, PA, USA. plo4@pitt.edu. |
| Source: | Nature communications [Nat Commun] 2025 Dec 07; Vol. 17 (1), pp. 6. Date of Electronic Publication: 2025 Dec 07. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
Be the first to leave a comment!
