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Preclinical Efficacy of TSL2109 in Prostate Cancer Treatment and Overcoming Enzalutamide Resistance.

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Title: Preclinical Efficacy of TSL2109 in Prostate Cancer Treatment and Overcoming Enzalutamide Resistance.
Authors: Yuan K; State Key Laboratory of Natural Medicines and Jiangsu Provincial Key Laboratory of Targetome and innovative Drugs Medicines, China Pharmaceutical University, Nanjing 211198, China.; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China.; Institute of Innovative Drug, China Pharmaceutical University, Nanjing 211198, China., Wang W; State Key Laboratory of Natural Medicines and Jiangsu Provincial Key Laboratory of Targetome and innovative Drugs Medicines, China Pharmaceutical University, Nanjing 211198, China.; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China.; Tasly Academy, Tasly Pharmaceutical Group Co., Ltd., Tianjin 300410, China., Tong C; State Key Laboratory of Natural Medicines and Jiangsu Provincial Key Laboratory of Targetome and innovative Drugs Medicines, China Pharmaceutical University, Nanjing 211198, China.; Department of Pharmacology, School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China., Yang H; State Key Laboratory of Natural Medicines and Jiangsu Provincial Key Laboratory of Targetome and innovative Drugs Medicines, China Pharmaceutical University, Nanjing 211198, China.; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China., Chen W; State Key Laboratory of Natural Medicines and Jiangsu Provincial Key Laboratory of Targetome and innovative Drugs Medicines, China Pharmaceutical University, Nanjing 211198, China.; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China., Zhang XY; State Key Laboratory of Natural Medicines and Jiangsu Provincial Key Laboratory of Targetome and innovative Drugs Medicines, China Pharmaceutical University, Nanjing 211198, China.; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China.; Institute of Innovative Drug, China Pharmaceutical University, Nanjing 211198, China., Wang G; Tasly Academy, Tasly Pharmaceutical Group Co., Ltd., Tianjin 300410, China., Li G; Tasly Academy, Tasly Pharmaceutical Group Co., Ltd., Tianjin 300410, China., Chen Y; State Key Laboratory of Natural Medicines and Jiangsu Provincial Key Laboratory of Targetome and innovative Drugs Medicines, China Pharmaceutical University, Nanjing 211198, China.; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China., Zhuang X; State Key Laboratory of Natural Medicines and Jiangsu Provincial Key Laboratory of Targetome and innovative Drugs Medicines, China Pharmaceutical University, Nanjing 211198, China.; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China., Min W; State Key Laboratory of Natural Medicines and Jiangsu Provincial Key Laboratory of Targetome and innovative Drugs Medicines, China Pharmaceutical University, Nanjing 211198, China.; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China., Hao H; State Key Laboratory of Natural Medicines and Jiangsu Provincial Key Laboratory of Targetome and innovative Drugs Medicines, China Pharmaceutical University, Nanjing 211198, China.; Department of Pharmacology, School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China.; Institute of Innovative Drug, China Pharmaceutical University, Nanjing 211198, China., Xiao Y; State Key Laboratory of Natural Medicines and Jiangsu Provincial Key Laboratory of Targetome and innovative Drugs Medicines, China Pharmaceutical University, Nanjing 211198, China.; Department of Pharmacology, School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China.; Institute of Innovative Drug, China Pharmaceutical University, Nanjing 211198, China., Ma X; Tasly Academy, Tasly Pharmaceutical Group Co., Ltd., Tianjin 300410, China., Yang P; State Key Laboratory of Natural Medicines and Jiangsu Provincial Key Laboratory of Targetome and innovative Drugs Medicines, China Pharmaceutical University, Nanjing 211198, China.; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China.; Institute of Innovative Drug, China Pharmaceutical University, Nanjing 211198, China.
Source: Journal of medicinal chemistry [J Med Chem] 2025 Dec 25; Vol. 68 (24), pp. 25783-25793. Date of Electronic Publication: 2025 Dec 08.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
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  Data: Preclinical Efficacy of TSL2109 in Prostate Cancer Treatment and Overcoming Enzalutamide Resistance.
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  Data: <searchLink fieldCode="AU" term="%22Yuan+K%22">Yuan K</searchLink>; State Key Laboratory of Natural Medicines and Jiangsu Provincial Key Laboratory of Targetome and innovative Drugs Medicines, China Pharmaceutical University, Nanjing 211198, China.; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China.; Institute of Innovative Drug, China Pharmaceutical University, Nanjing 211198, China.<br /><searchLink fieldCode="AU" term="%22Wang+W%22">Wang W</searchLink>; State Key Laboratory of Natural Medicines and Jiangsu Provincial Key Laboratory of Targetome and innovative Drugs Medicines, China Pharmaceutical University, Nanjing 211198, China.; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China.; Tasly Academy, Tasly Pharmaceutical Group Co., Ltd., Tianjin 300410, China.<br /><searchLink fieldCode="AU" term="%22Tong+C%22">Tong C</searchLink>; State Key Laboratory of Natural Medicines and Jiangsu Provincial Key Laboratory of Targetome and innovative Drugs Medicines, China Pharmaceutical University, Nanjing 211198, China.; Department of Pharmacology, School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China.<br /><searchLink fieldCode="AU" term="%22Yang+H%22">Yang H</searchLink>; State Key Laboratory of Natural Medicines and Jiangsu Provincial Key Laboratory of Targetome and innovative Drugs Medicines, China Pharmaceutical University, Nanjing 211198, China.; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China.<br /><searchLink fieldCode="AU" term="%22Chen+W%22">Chen W</searchLink>; State Key Laboratory of Natural Medicines and Jiangsu Provincial Key Laboratory of Targetome and innovative Drugs Medicines, China Pharmaceutical University, Nanjing 211198, China.; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China.<br /><searchLink fieldCode="AU" term="%22Zhang+XY%22">Zhang XY</searchLink>; State Key Laboratory of Natural Medicines and Jiangsu Provincial Key Laboratory of Targetome and innovative Drugs Medicines, China Pharmaceutical University, Nanjing 211198, China.; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China.; Institute of Innovative Drug, China Pharmaceutical University, Nanjing 211198, China.<br /><searchLink fieldCode="AU" term="%22Wang+G%22">Wang G</searchLink>; Tasly Academy, Tasly Pharmaceutical Group Co., Ltd., Tianjin 300410, China.<br /><searchLink fieldCode="AU" term="%22Li+G%22">Li G</searchLink>; Tasly Academy, Tasly Pharmaceutical Group Co., Ltd., Tianjin 300410, China.<br /><searchLink fieldCode="AU" term="%22Chen+Y%22">Chen Y</searchLink>; State Key Laboratory of Natural Medicines and Jiangsu Provincial Key Laboratory of Targetome and innovative Drugs Medicines, China Pharmaceutical University, Nanjing 211198, China.; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China.<br /><searchLink fieldCode="AU" term="%22Zhuang+X%22">Zhuang X</searchLink>; State Key Laboratory of Natural Medicines and Jiangsu Provincial Key Laboratory of Targetome and innovative Drugs Medicines, China Pharmaceutical University, Nanjing 211198, China.; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China.<br /><searchLink fieldCode="AU" term="%22Min+W%22">Min W</searchLink>; State Key Laboratory of Natural Medicines and Jiangsu Provincial Key Laboratory of Targetome and innovative Drugs Medicines, China Pharmaceutical University, Nanjing 211198, China.; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China.<br /><searchLink fieldCode="AU" term="%22Hao+H%22">Hao H</searchLink>; State Key Laboratory of Natural Medicines and Jiangsu Provincial Key Laboratory of Targetome and innovative Drugs Medicines, China Pharmaceutical University, Nanjing 211198, China.; Department of Pharmacology, School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China.; Institute of Innovative Drug, China Pharmaceutical University, Nanjing 211198, China.<br /><searchLink fieldCode="AU" term="%22Xiao+Y%22">Xiao Y</searchLink>; State Key Laboratory of Natural Medicines and Jiangsu Provincial Key Laboratory of Targetome and innovative Drugs Medicines, China Pharmaceutical University, Nanjing 211198, China.; Department of Pharmacology, School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China.; Institute of Innovative Drug, China Pharmaceutical University, Nanjing 211198, China.<br /><searchLink fieldCode="AU" term="%22Ma+X%22">Ma X</searchLink>; Tasly Academy, Tasly Pharmaceutical Group Co., Ltd., Tianjin 300410, China.<br /><searchLink fieldCode="AU" term="%22Yang+P%22">Yang P</searchLink>; State Key Laboratory of Natural Medicines and Jiangsu Provincial Key Laboratory of Targetome and innovative Drugs Medicines, China Pharmaceutical University, Nanjing 211198, China.; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China.; Institute of Innovative Drug, China Pharmaceutical University, Nanjing 211198, China.
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  Data: <searchLink fieldCode="JN" term="%229716531%22">Journal of medicinal chemistry</searchLink> [J Med Chem] 2025 Dec 25; Vol. 68 (24), pp. 25783-25793. <i>Date of Electronic Publication: </i>2025 Dec 08.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Chemical+Society%22">American Chemical Society </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9716531 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1520-4804 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200222623%22">00222623 </searchLink><i>NLM ISO Abbreviation: </i>J Med Chem <i>Subsets: </i>MEDLINE
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RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1021/acs.jmedchem.5c03245
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      – Code: eng
        Text: English
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        StartPage: 25783
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      – TitleFull: Preclinical Efficacy of TSL2109 in Prostate Cancer Treatment and Overcoming Enzalutamide Resistance.
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              M: 12
              Text: 2025 Dec 25
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              Y: 2025
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