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HER2CLIMB-05: A Phase III Study of Tucatinib Versus Placebo in Combination With Trastuzumab and Pertuzumab as First-Line Maintenance Therapy for HER2+ Metastatic Breast Cancer.

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Title: HER2CLIMB-05: A Phase III Study of Tucatinib Versus Placebo in Combination With Trastuzumab and Pertuzumab as First-Line Maintenance Therapy for HER2+ Metastatic Breast Cancer.
Authors: Dieras V; Medical Oncology Department, Centre Eugène Marquis, Rennes, France., Curigliano G; European Institute of Oncology, IRCCS, Milano, Italy.; Department of Oncology and Hemato-Oncology, University of Milano, Milano, Italy., Martin M; Medical Oncology Service, Hospital General Universitario Gregorio Marañon, Universidad Complutense, CIBERONC, GEICAM, Madrid, Spain., Lerebours F; Institut Curie, Saint-Cloud, Paris, France., Tsurutani J; The Innovative Center of Translational Research and Clinical Science for Cancer Therapy, Showa Medical University Hospital, Tokyo, Japan., Savard MF; Department of Medicine, The Ottawa Hospital Cancer Centre, Ottawa, ON, Canada., Jerzak KJ; Department of Medicine, Sunnybrook Odette Cancer Centre, University of Toronto, Toronto, ON, Canada., Hu X; Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai, China., Martins de Aquino Pimentel LC; Medical Oncology, Liga Norte-Rio Grandense Contra o Cancer, Natal, Brazil., O'Sullivan CC; Department of Medical Oncology, Mayo Clinic, Rochester, MN., Tokunaga E; Department of Breast Oncology, National Hospital Organization Kyushu Cancer Center, Fukuoka, Japan., Okines A; Medical Oncology, The Royal Marsden NHS Foundation Trust, London, United Kingdom.; Institute of Cancer Research, London, United Kingdom., Huang CS; Breast Care Center, National Taiwan University Hospital, Taipei, Taiwan., Jacot W; Département d'Oncologie Médicale, Institut Regional du Cancer de Montpellier, Montpellier University, INSERM U1194, Montpellier, France., Sohn J; Division of Medical Oncology, Yonsei Cancer Center, Yonsei University Health System, Seoul, Republic of Korea., Cronemberger Silva E; Medical Oncology, Centro Regional Integrado de Oncologia (CRIO), Fortaleza, Brazil., Mueller V; Department of Gynecology and University Breast Center, Universitaetsklinikum Hamburg-Eppendorf, Hamburg, Germany., Yang S; Biostatistics, Pfizer Inc, Bothell, WA., Granata G; Oncology Late Stage Development, Pfizer AG, Zug, Switzerland., Shen Q; Oncology, Research and Development, Pfizer Inc, Collegeville, PA., Santarpia L; Oncology, Research and Development, Pfizer AG, Zug, Switzerland., Hamilton E; Medical Oncology, Sarah Cannon Research Institute, Nashville, TN.
Corporate Authors: HER2CLIMB-05 Investigators
Source: Journal of clinical oncology : official journal of the American Society of Clinical Oncology [J Clin Oncol] 2026 Jun 10; Vol. 44 (17), pp. 1597-1607. Date of Electronic Publication: 2025 Dec 10.
Publication Type: Journal Article; Clinical Trial, Phase III; Randomized Controlled Trial; Multicenter Study
Journal Info: Publisher: American Society of Clinical Oncology Country of Publication: United States NLM ID: 8309333 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1527-7755 (Electronic) Linking ISSN: 0732183X NLM ISO Abbreviation: J Clin Oncol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: HER2CLIMB-05: A Phase III Study of Tucatinib Versus Placebo in Combination With Trastuzumab and Pertuzumab as First-Line Maintenance Therapy for HER2+ Metastatic Breast Cancer.
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  Data: <searchLink fieldCode="AU" term="%22Dieras+V%22">Dieras V</searchLink>; Medical Oncology Department, Centre Eugène Marquis, Rennes, France.<br /><searchLink fieldCode="AU" term="%22Curigliano+G%22">Curigliano G</searchLink>; European Institute of Oncology, IRCCS, Milano, Italy.; Department of Oncology and Hemato-Oncology, University of Milano, Milano, Italy.<br /><searchLink fieldCode="AU" term="%22Martin+M%22">Martin M</searchLink>; Medical Oncology Service, Hospital General Universitario Gregorio Marañon, Universidad Complutense, CIBERONC, GEICAM, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Lerebours+F%22">Lerebours F</searchLink>; Institut Curie, Saint-Cloud, Paris, France.<br /><searchLink fieldCode="AU" term="%22Tsurutani+J%22">Tsurutani J</searchLink>; The Innovative Center of Translational Research and Clinical Science for Cancer Therapy, Showa Medical University Hospital, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Savard+MF%22">Savard MF</searchLink>; Department of Medicine, The Ottawa Hospital Cancer Centre, Ottawa, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Jerzak+KJ%22">Jerzak KJ</searchLink>; Department of Medicine, Sunnybrook Odette Cancer Centre, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Hu+X%22">Hu X</searchLink>; Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Martins+de+Aquino+Pimentel+LC%22">Martins de Aquino Pimentel LC</searchLink>; Medical Oncology, Liga Norte-Rio Grandense Contra o Cancer, Natal, Brazil.<br /><searchLink fieldCode="AU" term="%22O'Sullivan+CC%22">O'Sullivan CC</searchLink>; Department of Medical Oncology, Mayo Clinic, Rochester, MN.<br /><searchLink fieldCode="AU" term="%22Tokunaga+E%22">Tokunaga E</searchLink>; Department of Breast Oncology, National Hospital Organization Kyushu Cancer Center, Fukuoka, Japan.<br /><searchLink fieldCode="AU" term="%22Okines+A%22">Okines A</searchLink>; Medical Oncology, The Royal Marsden NHS Foundation Trust, London, United Kingdom.; Institute of Cancer Research, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Huang+CS%22">Huang CS</searchLink>; Breast Care Center, National Taiwan University Hospital, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Jacot+W%22">Jacot W</searchLink>; Département d'Oncologie Médicale, Institut Regional du Cancer de Montpellier, Montpellier University, INSERM U1194, Montpellier, France.<br /><searchLink fieldCode="AU" term="%22Sohn+J%22">Sohn J</searchLink>; Division of Medical Oncology, Yonsei Cancer Center, Yonsei University Health System, Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Cronemberger+Silva+E%22">Cronemberger Silva E</searchLink>; Medical Oncology, Centro Regional Integrado de Oncologia (CRIO), Fortaleza, Brazil.<br /><searchLink fieldCode="AU" term="%22Mueller+V%22">Mueller V</searchLink>; Department of Gynecology and University Breast Center, Universitaetsklinikum Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Yang+S%22">Yang S</searchLink>; Biostatistics, Pfizer Inc, Bothell, WA.<br /><searchLink fieldCode="AU" term="%22Granata+G%22">Granata G</searchLink>; Oncology Late Stage Development, Pfizer AG, Zug, Switzerland.<br /><searchLink fieldCode="AU" term="%22Shen+Q%22">Shen Q</searchLink>; Oncology, Research and Development, Pfizer Inc, Collegeville, PA.<br /><searchLink fieldCode="AU" term="%22Santarpia+L%22">Santarpia L</searchLink>; Oncology, Research and Development, Pfizer AG, Zug, Switzerland.<br /><searchLink fieldCode="AU" term="%22Hamilton+E%22">Hamilton E</searchLink>; Medical Oncology, Sarah Cannon Research Institute, Nashville, TN.
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  Data: <searchLink fieldCode="JN" term="%228309333%22">Journal of clinical oncology : official journal of the American Society of Clinical Oncology</searchLink> [J Clin Oncol] 2026 Jun 10; Vol. 44 (17), pp. 1597-1607. <i>Date of Electronic Publication: </i>2025 Dec 10.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Society+of+Clinical+Oncology%22">American Society of Clinical Oncology </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>8309333 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1527-7755 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%220732183X%22">0732183X </searchLink><i>NLM ISO Abbreviation: </i>J Clin Oncol <i>Subsets: </i>MEDLINE
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