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Lactic acid promotes an MDSC-like phenotype via HIF1α stabilization with impact on prognosis in renal cell carcinoma.

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Title: Lactic acid promotes an MDSC-like phenotype via HIF1α stabilization with impact on prognosis in renal cell carcinoma.
Authors: Babl N; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany; Leibniz Institute for Immunotherapy (LIT), Regensburg, Germany. Electronic address: nathalie.babl@ukr.de., Voll F; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany; Leibniz Institute for Immunotherapy (LIT), Regensburg, Germany., Martowicz A; Department of Internal Medicine V, Haematology & Oncology, Comprehensive Cancer Center Innsbruck (CCCI) and Tyrolean Cancer Research Institute (TKFI), Medical University of Innsbruck, Innsbruck, Austria., Bruss C; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany., Maddaloni M; Leibniz Institute for Immunotherapy (LIT), Regensburg, Germany., Schmidl C; Leibniz Institute for Immunotherapy (LIT), Regensburg, Germany., Rehli M; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany; Leibniz Institute for Immunotherapy (LIT), Regensburg, Germany., Loipfinger S; Leibniz Institute for Immunotherapy (LIT), Regensburg, Germany., Strieder N; Leibniz Institute for Immunotherapy (LIT), Regensburg, Germany., Gebhard C; Leibniz Institute for Immunotherapy (LIT), Regensburg, Germany., Hoffmann P; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany; Leibniz Institute for Immunotherapy (LIT), Regensburg, Germany., Singh SM; School of Biotechnology, Institute of Science, Banaras Hindu University, Varanasi, Uttar Pradesh, India., Sala-Hojman A; Merck Healthcare KGaA, Darmstadt, Germany., Ferretti R; EMD Serono Research & Development Institute, Inc., Billerica, MA, USA, an affiliate of Merck KGaA., Matos C; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany; Leibniz Institute for Immunotherapy (LIT), Regensburg, Germany., Simon M; Leibniz Institute for Immunotherapy (LIT), Regensburg, Germany; Division of Applied Bioinformatics, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany., Brummer C; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany., Schnell A; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany., Hofbauer J; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany., Decking SM; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany; Leibniz Institute for Immunotherapy (LIT), Regensburg, Germany; Department of Otorhinolaryngology, University Hospital Regensburg, Regensburg, Germany., Hau P; Department of Neurology and Wilhelm Sander-NeuroOncology Unit, University Hospital Regensburg, Regensburg, Germany., Vollmann-Zwerenz A; Department of Neurology and Wilhelm Sander-NeuroOncology Unit, University Hospital Regensburg, Regensburg, Germany., Dettmer K; Institute of Functional Genomics, University of Regensburg, Regensburg, Germany., Oefner PJ; Institute of Functional Genomics, University of Regensburg, Regensburg, Germany., Althammer M; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany., Laufs J; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany., Friedl S; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany., Heinrich T; Merck Healthcare KGaA, Darmstadt, Germany., Herhaus C; Merck Healthcare KGaA, Darmstadt, Germany., Evert K; Institute of Pathology, University of Regensburg, Regensburg, Germany., Mayr R; Department of Urology, Caritas St. Josef Medical Centre, University of Regensburg, Regensburg, Germany., Afonso J; Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Campus of Gualtar, 4710-057, Braga, Portugal; 2ICVS/3B's-PT Government Associate Laboratory, Braga/Guimarães, Portugal., Baltazar F; Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Campus of Gualtar, 4710-057, Braga, Portugal; 2ICVS/3B's-PT Government Associate Laboratory, Braga/Guimarães, Portugal., Herr W; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany., Siska PJ; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany., Renner K; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany; Department of Otorhinolaryngology, University Hospital Regensburg, Regensburg, Germany., Kreutz M; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany; Leibniz Institute for Immunotherapy (LIT), Regensburg, Germany. Electronic address: marina.kreutz@ukr.de.
Source: Cancer letters [Cancer Lett] 2026 Feb 28; Vol. 639, pp. 218209. Date of Electronic Publication: 2025 Dec 08.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Ireland Country of Publication: Ireland NLM ID: 7600053 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7980 (Electronic) Linking ISSN: 03043835 NLM ISO Abbreviation: Cancer Lett Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Lactic acid promotes an MDSC-like phenotype via HIF1α stabilization with impact on prognosis in renal cell carcinoma.
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  Data: <searchLink fieldCode="AU" term="%22Babl+N%22">Babl N</searchLink>; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany; Leibniz Institute for Immunotherapy (LIT), Regensburg, Germany. Electronic address: nathalie.babl@ukr.de.<br /><searchLink fieldCode="AU" term="%22Voll+F%22">Voll F</searchLink>; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany; Leibniz Institute for Immunotherapy (LIT), Regensburg, Germany.<br /><searchLink fieldCode="AU" term="%22Martowicz+A%22">Martowicz A</searchLink>; Department of Internal Medicine V, Haematology & Oncology, Comprehensive Cancer Center Innsbruck (CCCI) and Tyrolean Cancer Research Institute (TKFI), Medical University of Innsbruck, Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Bruss+C%22">Bruss C</searchLink>; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany.<br /><searchLink fieldCode="AU" term="%22Maddaloni+M%22">Maddaloni M</searchLink>; Leibniz Institute for Immunotherapy (LIT), Regensburg, Germany.<br /><searchLink fieldCode="AU" term="%22Schmidl+C%22">Schmidl C</searchLink>; Leibniz Institute for Immunotherapy (LIT), Regensburg, Germany.<br /><searchLink fieldCode="AU" term="%22Rehli+M%22">Rehli M</searchLink>; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany; Leibniz Institute for Immunotherapy (LIT), Regensburg, Germany.<br /><searchLink fieldCode="AU" term="%22Loipfinger+S%22">Loipfinger S</searchLink>; Leibniz Institute for Immunotherapy (LIT), Regensburg, Germany.<br /><searchLink fieldCode="AU" term="%22Strieder+N%22">Strieder N</searchLink>; Leibniz Institute for Immunotherapy (LIT), Regensburg, Germany.<br /><searchLink fieldCode="AU" term="%22Gebhard+C%22">Gebhard C</searchLink>; Leibniz Institute for Immunotherapy (LIT), Regensburg, Germany.<br /><searchLink fieldCode="AU" term="%22Hoffmann+P%22">Hoffmann P</searchLink>; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany; Leibniz Institute for Immunotherapy (LIT), Regensburg, Germany.<br /><searchLink fieldCode="AU" term="%22Singh+SM%22">Singh SM</searchLink>; School of Biotechnology, Institute of Science, Banaras Hindu University, Varanasi, Uttar Pradesh, India.<br /><searchLink fieldCode="AU" term="%22Sala-Hojman+A%22">Sala-Hojman A</searchLink>; Merck Healthcare KGaA, Darmstadt, Germany.<br /><searchLink fieldCode="AU" term="%22Ferretti+R%22">Ferretti R</searchLink>; EMD Serono Research & Development Institute, Inc., Billerica, MA, USA, an affiliate of Merck KGaA.<br /><searchLink fieldCode="AU" term="%22Matos+C%22">Matos C</searchLink>; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany; Leibniz Institute for Immunotherapy (LIT), Regensburg, Germany.<br /><searchLink fieldCode="AU" term="%22Simon+M%22">Simon M</searchLink>; Leibniz Institute for Immunotherapy (LIT), Regensburg, Germany; Division of Applied Bioinformatics, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Brummer+C%22">Brummer C</searchLink>; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany.<br /><searchLink fieldCode="AU" term="%22Schnell+A%22">Schnell A</searchLink>; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany.<br /><searchLink fieldCode="AU" term="%22Hofbauer+J%22">Hofbauer J</searchLink>; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany.<br /><searchLink fieldCode="AU" term="%22Decking+SM%22">Decking SM</searchLink>; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany; Leibniz Institute for Immunotherapy (LIT), Regensburg, Germany; Department of Otorhinolaryngology, University Hospital Regensburg, Regensburg, Germany.<br /><searchLink fieldCode="AU" term="%22Hau+P%22">Hau P</searchLink>; Department of Neurology and Wilhelm Sander-NeuroOncology Unit, University Hospital Regensburg, Regensburg, Germany.<br /><searchLink fieldCode="AU" term="%22Vollmann-Zwerenz+A%22">Vollmann-Zwerenz A</searchLink>; Department of Neurology and Wilhelm Sander-NeuroOncology Unit, University Hospital Regensburg, Regensburg, Germany.<br /><searchLink fieldCode="AU" term="%22Dettmer+K%22">Dettmer K</searchLink>; Institute of Functional Genomics, University of Regensburg, Regensburg, Germany.<br /><searchLink fieldCode="AU" term="%22Oefner+PJ%22">Oefner PJ</searchLink>; Institute of Functional Genomics, University of Regensburg, Regensburg, Germany.<br /><searchLink fieldCode="AU" term="%22Althammer+M%22">Althammer M</searchLink>; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany.<br /><searchLink fieldCode="AU" term="%22Laufs+J%22">Laufs J</searchLink>; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany.<br /><searchLink fieldCode="AU" term="%22Friedl+S%22">Friedl S</searchLink>; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany.<br /><searchLink fieldCode="AU" term="%22Heinrich+T%22">Heinrich T</searchLink>; Merck Healthcare KGaA, Darmstadt, Germany.<br /><searchLink fieldCode="AU" term="%22Herhaus+C%22">Herhaus C</searchLink>; Merck Healthcare KGaA, Darmstadt, Germany.<br /><searchLink fieldCode="AU" term="%22Evert+K%22">Evert K</searchLink>; Institute of Pathology, University of Regensburg, Regensburg, Germany.<br /><searchLink fieldCode="AU" term="%22Mayr+R%22">Mayr R</searchLink>; Department of Urology, Caritas St. Josef Medical Centre, University of Regensburg, Regensburg, Germany.<br /><searchLink fieldCode="AU" term="%22Afonso+J%22">Afonso J</searchLink>; Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Campus of Gualtar, 4710-057, Braga, Portugal; 2ICVS/3B's-PT Government Associate Laboratory, Braga/Guimarães, Portugal.<br /><searchLink fieldCode="AU" term="%22Baltazar+F%22">Baltazar F</searchLink>; Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Campus of Gualtar, 4710-057, Braga, Portugal; 2ICVS/3B's-PT Government Associate Laboratory, Braga/Guimarães, Portugal.<br /><searchLink fieldCode="AU" term="%22Herr+W%22">Herr W</searchLink>; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany.<br /><searchLink fieldCode="AU" term="%22Siska+PJ%22">Siska PJ</searchLink>; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany.<br /><searchLink fieldCode="AU" term="%22Renner+K%22">Renner K</searchLink>; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany; Department of Otorhinolaryngology, University Hospital Regensburg, Regensburg, Germany.<br /><searchLink fieldCode="AU" term="%22Kreutz+M%22">Kreutz M</searchLink>; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany; Leibniz Institute for Immunotherapy (LIT), Regensburg, Germany. Electronic address: marina.kreutz@ukr.de.
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  Data: <searchLink fieldCode="JN" term="%227600053%22">Cancer letters</searchLink> [Cancer Lett] 2026 Feb 28; Vol. 639, pp. 218209. <i>Date of Electronic Publication: </i>2025 Dec 08.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Science+Ireland%22">Elsevier Science Ireland </searchLink><i>Country of Publication: </i>Ireland <i>NLM ID: </i>7600053 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1872-7980 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2203043835%22">03043835 </searchLink><i>NLM ISO Abbreviation: </i>Cancer Lett <i>Subsets: </i>MEDLINE
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