Lactic acid promotes an MDSC-like phenotype via HIF1α stabilization with impact on prognosis in renal cell carcinoma.
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| Title: | Lactic acid promotes an MDSC-like phenotype via HIF1α stabilization with impact on prognosis in renal cell carcinoma. |
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| Authors: | Babl N; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany; Leibniz Institute for Immunotherapy (LIT), Regensburg, Germany. Electronic address: nathalie.babl@ukr.de., Voll F; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany; Leibniz Institute for Immunotherapy (LIT), Regensburg, Germany., Martowicz A; Department of Internal Medicine V, Haematology & Oncology, Comprehensive Cancer Center Innsbruck (CCCI) and Tyrolean Cancer Research Institute (TKFI), Medical University of Innsbruck, Innsbruck, Austria., Bruss C; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany., Maddaloni M; Leibniz Institute for Immunotherapy (LIT), Regensburg, Germany., Schmidl C; Leibniz Institute for Immunotherapy (LIT), Regensburg, Germany., Rehli M; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany; Leibniz Institute for Immunotherapy (LIT), Regensburg, Germany., Loipfinger S; Leibniz Institute for Immunotherapy (LIT), Regensburg, Germany., Strieder N; Leibniz Institute for Immunotherapy (LIT), Regensburg, Germany., Gebhard C; Leibniz Institute for Immunotherapy (LIT), Regensburg, Germany., Hoffmann P; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany; Leibniz Institute for Immunotherapy (LIT), Regensburg, Germany., Singh SM; School of Biotechnology, Institute of Science, Banaras Hindu University, Varanasi, Uttar Pradesh, India., Sala-Hojman A; Merck Healthcare KGaA, Darmstadt, Germany., Ferretti R; EMD Serono Research & Development Institute, Inc., Billerica, MA, USA, an affiliate of Merck KGaA., Matos C; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany; Leibniz Institute for Immunotherapy (LIT), Regensburg, Germany., Simon M; Leibniz Institute for Immunotherapy (LIT), Regensburg, Germany; Division of Applied Bioinformatics, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany., Brummer C; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany., Schnell A; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany., Hofbauer J; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany., Decking SM; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany; Leibniz Institute for Immunotherapy (LIT), Regensburg, Germany; Department of Otorhinolaryngology, University Hospital Regensburg, Regensburg, Germany., Hau P; Department of Neurology and Wilhelm Sander-NeuroOncology Unit, University Hospital Regensburg, Regensburg, Germany., Vollmann-Zwerenz A; Department of Neurology and Wilhelm Sander-NeuroOncology Unit, University Hospital Regensburg, Regensburg, Germany., Dettmer K; Institute of Functional Genomics, University of Regensburg, Regensburg, Germany., Oefner PJ; Institute of Functional Genomics, University of Regensburg, Regensburg, Germany., Althammer M; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany., Laufs J; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany., Friedl S; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany., Heinrich T; Merck Healthcare KGaA, Darmstadt, Germany., Herhaus C; Merck Healthcare KGaA, Darmstadt, Germany., Evert K; Institute of Pathology, University of Regensburg, Regensburg, Germany., Mayr R; Department of Urology, Caritas St. Josef Medical Centre, University of Regensburg, Regensburg, Germany., Afonso J; Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Campus of Gualtar, 4710-057, Braga, Portugal; 2ICVS/3B's-PT Government Associate Laboratory, Braga/Guimarães, Portugal., Baltazar F; Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Campus of Gualtar, 4710-057, Braga, Portugal; 2ICVS/3B's-PT Government Associate Laboratory, Braga/Guimarães, Portugal., Herr W; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany., Siska PJ; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany., Renner K; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany; Department of Otorhinolaryngology, University Hospital Regensburg, Regensburg, Germany., Kreutz M; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany; Leibniz Institute for Immunotherapy (LIT), Regensburg, Germany. Electronic address: marina.kreutz@ukr.de. |
| Source: | Cancer letters [Cancer Lett] 2026 Feb 28; Vol. 639, pp. 218209. Date of Electronic Publication: 2025 Dec 08. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Elsevier Science Ireland Country of Publication: Ireland NLM ID: 7600053 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7980 (Electronic) Linking ISSN: 03043835 NLM ISO Abbreviation: Cancer Lett Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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