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Participant diversity and inclusive trial design: a meta-epidemiologic study of Canadian randomized clinical trials.

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Title: Participant diversity and inclusive trial design: a meta-epidemiologic study of Canadian randomized clinical trials.
Authors: Ruzycki SM; Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada; Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada. Electronic address: shannon.ruzycki@ucalgary.ca., Lithgow KC; Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada., Song C; Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada., Taylor S; Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada., Subramanian A; Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada., Li M; Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada., Happ S; Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada., Shea M; Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada., Oladimeji D; Faculty of Medicine & Dentistry, University of Alberta, Edmonton, Alberta, Canada., Clark W; Faculty of Medicine & Dentistry, University of Alberta, Edmonton, Alberta, Canada., Fergusson DA; Department of Medicine, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Ontario, Canada., Isenberg SR; Department of Medicine, Bruyere Health Research Institute, University of Ottawa, Ottawa, Ontario, Canada., Li P; Faculty of Medicine and Health Sciences, Department of Pediatrics, McGill University, Montreal, Quebec, Canada., Mehta S; Department of Medicine, Sinai Health System, Toronto, Ontario, Canada; Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Ontario, Canada., Nicholls SG; Methodological and Implementation Research (MIR), Ottawa Hospital Research Institute Office for Patient Engagement in Research Activity (OPERA), Ottawa Hospital Research Institute, Ottawa, Ontario, Canada., Pollock CL; Department of Physical Therapy, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada., Pilote L; Research Institute of the McGill University Health Centre, McGill university, Montreal, Quebec, Canada., Quinn AE; Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada; Department of Obstetrics and Gynecology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada., Buragadda S; Department of Medicine, Research Institute McGill University Health Center, Montreal, Quebec, Canada., Collister D; Faculty of Medicine & Dentistry, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada.
Corporate Authors: ACT AEC Consortium leadership and IDEA subcommittee
Source: Journal of clinical epidemiology [J Clin Epidemiol] 2026 Mar; Vol. 191, pp. 112098. Date of Electronic Publication: 2025 Dec 08.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 8801383 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-5921 (Electronic) Linking ISSN: 08954356 NLM ISO Abbreviation: J Clin Epidemiol Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Ruzycki+SM%22">Ruzycki SM</searchLink>; Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada; Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada. Electronic address: shannon.ruzycki@ucalgary.ca.<br /><searchLink fieldCode="AU" term="%22Lithgow+KC%22">Lithgow KC</searchLink>; Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.<br /><searchLink fieldCode="AU" term="%22Song+C%22">Song C</searchLink>; Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.<br /><searchLink fieldCode="AU" term="%22Taylor+S%22">Taylor S</searchLink>; Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.<br /><searchLink fieldCode="AU" term="%22Subramanian+A%22">Subramanian A</searchLink>; Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.<br /><searchLink fieldCode="AU" term="%22Li+M%22">Li M</searchLink>; Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.<br /><searchLink fieldCode="AU" term="%22Happ+S%22">Happ S</searchLink>; Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.<br /><searchLink fieldCode="AU" term="%22Shea+M%22">Shea M</searchLink>; Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.<br /><searchLink fieldCode="AU" term="%22Oladimeji+D%22">Oladimeji D</searchLink>; Faculty of Medicine & Dentistry, University of Alberta, Edmonton, Alberta, Canada.<br /><searchLink fieldCode="AU" term="%22Clark+W%22">Clark W</searchLink>; Faculty of Medicine & Dentistry, University of Alberta, Edmonton, Alberta, Canada.<br /><searchLink fieldCode="AU" term="%22Fergusson+DA%22">Fergusson DA</searchLink>; Department of Medicine, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Isenberg+SR%22">Isenberg SR</searchLink>; Department of Medicine, Bruyere Health Research Institute, University of Ottawa, Ottawa, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Li+P%22">Li P</searchLink>; Faculty of Medicine and Health Sciences, Department of Pediatrics, McGill University, Montreal, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Mehta+S%22">Mehta S</searchLink>; Department of Medicine, Sinai Health System, Toronto, Ontario, Canada; Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Nicholls+SG%22">Nicholls SG</searchLink>; Methodological and Implementation Research (MIR), Ottawa Hospital Research Institute Office for Patient Engagement in Research Activity (OPERA), Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Pollock+CL%22">Pollock CL</searchLink>; Department of Physical Therapy, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.<br /><searchLink fieldCode="AU" term="%22Pilote+L%22">Pilote L</searchLink>; Research Institute of the McGill University Health Centre, McGill university, Montreal, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Quinn+AE%22">Quinn AE</searchLink>; Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada; Department of Obstetrics and Gynecology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.<br /><searchLink fieldCode="AU" term="%22Buragadda+S%22">Buragadda S</searchLink>; Department of Medicine, Research Institute McGill University Health Center, Montreal, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Collister+D%22">Collister D</searchLink>; Faculty of Medicine & Dentistry, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada.
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  Data: <searchLink fieldCode="JN" term="%228801383%22">Journal of clinical epidemiology</searchLink> [J Clin Epidemiol] 2026 Mar; Vol. 191, pp. 112098. <i>Date of Electronic Publication: </i>2025 Dec 08.
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