Efficient production of ursodeoxycholic acid via a deep eutectic solvent-enabled 7α- and 7β-hydroxysteroid dehydrogenase cascade system with enhanced solubility of 7-keto-lithocholic acid.
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| Title: | Efficient production of ursodeoxycholic acid via a deep eutectic solvent-enabled 7α- and 7β-hydroxysteroid dehydrogenase cascade system with enhanced solubility of 7-keto-lithocholic acid. |
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| Authors: | Jeon BW; Department of Chemical Engineering, College of Engineering, Kyung Hee University, Yongin-si, Gyeonggi-do, 17104, Republic of Korea. Electronic address: bwjeon@khu.ac.kr., Jung YJ; Department of Biological and Chemical Engineering, Hongik University, Sejong-si, 30016, Republic of Korea. Electronic address: yejean22@gmail.com., Ryu MH; Green Carbon Research Center, Chemical & Process Technology Division, Korea Research Institute of Chemical Technology, 141 Gajeong-ro, Yuseong-gu, Daejeon, 34114, Republic of Korea. Electronic address: miheeryu@krict.re.kr., Lee S; Department of Biotechnology, The Catholic University of Korea, Bucheon, Gyeonggi-do, 14662, Republic of Korea. Electronic address: 2siseon85@gmail.com., Yoon J; Department of Chemical Engineering, College of Engineering, Kyung Hee University, Yongin-si, Gyeonggi-do, 17104, Republic of Korea. Electronic address: jh60821@naver.com., Lee EG; Ace biopharm Co., Ltd. Biotechnology Center, Bio-Venture Town, 1662 Yuseong-daero, Yuseong-gu, Daejeon, 34114, Republic of Korea. Electronic address: white2534@naver.com., Park JB; Ace biopharm Co., Ltd. Biotechnology Center, Bio-Venture Town, 1662 Yuseong-daero, Yuseong-gu, Daejeon, 34114, Republic of Korea. Electronic address: unitsaer@gmail.com., Jang HW; Ace biopharm Co., Ltd. Biotechnology Center, Bio-Venture Town, 1662 Yuseong-daero, Yuseong-gu, Daejeon, 34114, Republic of Korea. Electronic address: hwjang63@gmail.com., Hong YS; Chemical Biology Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju, 28116, Republic of Korea. Electronic address: hongsoo@kribb.re.kr., Ahn J; Biotechnology Process Engineering Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju, 28116, Republic of Korea. Electronic address: ahnjo@kribb.re.kr., Sung BH; Synthetic Biology Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, 34141, Republic of Korea; School of Biotechnology, Korea University of Science and Technology (UST), Daejeon, 34141, Republic of Korea; Graduate School of Engineering Biology, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 34141, Republic of Korea. Electronic address: bhsung@kribb.re.kr., Pandey A; Department of Biotechnology & Bioengineering, School of Biosciences & Technology, Galgotias University, Greater Noida, 203201, India. Electronic address: ashuthoshdut@gmail.com., Song BK; Research Center for Bio-based Chemicals, Korea Research Institute of Chemical Technology, Daejeon, 34114, Republic of Korea. Electronic address: bk2000s@naver.com., Park K; Department of Biological and Chemical Engineering, Hongik University, Sejong-si, 30016, Republic of Korea. Electronic address: pkm2510@hongik.ac.kr., Won W; Department of Chemical and Biological Engineering, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul, 02841, Republic of Korea. Electronic address: wwon@korea.ac.kr., Joo JC; Department of Chemical Engineering, College of Engineering, Kyung Hee University, Yongin-si, Gyeonggi-do, 17104, Republic of Korea. Electronic address: jcjoo@khu.ac.kr. |
| Source: | International journal of biological macromolecules [Int J Biol Macromol] 2026 Jan; Vol. 337 (Pt 2), pp. 149510. Date of Electronic Publication: 2025 Dec 09. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41380873 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Efficient production of ursodeoxycholic acid via a deep eutectic solvent-enabled 7α- and 7β-hydroxysteroid dehydrogenase cascade system with enhanced solubility of 7-keto-lithocholic acid. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Jeon+BW%22">Jeon BW</searchLink>; Department of Chemical Engineering, College of Engineering, Kyung Hee University, Yongin-si, Gyeonggi-do, 17104, Republic of Korea. Electronic address: bwjeon@khu.ac.kr.<br /><searchLink fieldCode="AU" term="%22Jung+YJ%22">Jung YJ</searchLink>; Department of Biological and Chemical Engineering, Hongik University, Sejong-si, 30016, Republic of Korea. Electronic address: yejean22@gmail.com.<br /><searchLink fieldCode="AU" term="%22Ryu+MH%22">Ryu MH</searchLink>; Green Carbon Research Center, Chemical & Process Technology Division, Korea Research Institute of Chemical Technology, 141 Gajeong-ro, Yuseong-gu, Daejeon, 34114, Republic of Korea. Electronic address: miheeryu@krict.re.kr.<br /><searchLink fieldCode="AU" term="%22Lee+S%22">Lee S</searchLink>; Department of Biotechnology, The Catholic University of Korea, Bucheon, Gyeonggi-do, 14662, Republic of Korea. Electronic address: 2siseon85@gmail.com.<br /><searchLink fieldCode="AU" term="%22Yoon+J%22">Yoon J</searchLink>; Department of Chemical Engineering, College of Engineering, Kyung Hee University, Yongin-si, Gyeonggi-do, 17104, Republic of Korea. Electronic address: jh60821@naver.com.<br /><searchLink fieldCode="AU" term="%22Lee+EG%22">Lee EG</searchLink>; Ace biopharm Co., Ltd. Biotechnology Center, Bio-Venture Town, 1662 Yuseong-daero, Yuseong-gu, Daejeon, 34114, Republic of Korea. Electronic address: white2534@naver.com.<br /><searchLink fieldCode="AU" term="%22Park+JB%22">Park JB</searchLink>; Ace biopharm Co., Ltd. Biotechnology Center, Bio-Venture Town, 1662 Yuseong-daero, Yuseong-gu, Daejeon, 34114, Republic of Korea. Electronic address: unitsaer@gmail.com.<br /><searchLink fieldCode="AU" term="%22Jang+HW%22">Jang HW</searchLink>; Ace biopharm Co., Ltd. Biotechnology Center, Bio-Venture Town, 1662 Yuseong-daero, Yuseong-gu, Daejeon, 34114, Republic of Korea. Electronic address: hwjang63@gmail.com.<br /><searchLink fieldCode="AU" term="%22Hong+YS%22">Hong YS</searchLink>; Chemical Biology Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju, 28116, Republic of Korea. Electronic address: hongsoo@kribb.re.kr.<br /><searchLink fieldCode="AU" term="%22Ahn+J%22">Ahn J</searchLink>; Biotechnology Process Engineering Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju, 28116, Republic of Korea. Electronic address: ahnjo@kribb.re.kr.<br /><searchLink fieldCode="AU" term="%22Sung+BH%22">Sung BH</searchLink>; Synthetic Biology Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, 34141, Republic of Korea; School of Biotechnology, Korea University of Science and Technology (UST), Daejeon, 34141, Republic of Korea; Graduate School of Engineering Biology, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 34141, Republic of Korea. Electronic address: bhsung@kribb.re.kr.<br /><searchLink fieldCode="AU" term="%22Pandey+A%22">Pandey A</searchLink>; Department of Biotechnology & Bioengineering, School of Biosciences & Technology, Galgotias University, Greater Noida, 203201, India. Electronic address: ashuthoshdut@gmail.com.<br /><searchLink fieldCode="AU" term="%22Song+BK%22">Song BK</searchLink>; Research Center for Bio-based Chemicals, Korea Research Institute of Chemical Technology, Daejeon, 34114, Republic of Korea. Electronic address: bk2000s@naver.com.<br /><searchLink fieldCode="AU" term="%22Park+K%22">Park K</searchLink>; Department of Biological and Chemical Engineering, Hongik University, Sejong-si, 30016, Republic of Korea. Electronic address: pkm2510@hongik.ac.kr.<br /><searchLink fieldCode="AU" term="%22Won+W%22">Won W</searchLink>; Department of Chemical and Biological Engineering, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul, 02841, Republic of Korea. Electronic address: wwon@korea.ac.kr.<br /><searchLink fieldCode="AU" term="%22Joo+JC%22">Joo JC</searchLink>; Department of Chemical Engineering, College of Engineering, Kyung Hee University, Yongin-si, Gyeonggi-do, 17104, Republic of Korea. Electronic address: jcjoo@khu.ac.kr. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%227909578%22">International journal of biological macromolecules</searchLink> [Int J Biol Macromol] 2026 Jan; Vol. 337 (Pt 2), pp. 149510. <i>Date of Electronic Publication: </i>2025 Dec 09. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>7909578 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1879-0003 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2201418130%22">01418130 </searchLink><i>NLM ISO Abbreviation: </i>Int J Biol Macromol <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41380873 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/j.ijbiomac.2025.149510 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 149510 Titles: – TitleFull: Efficient production of ursodeoxycholic acid via a deep eutectic solvent-enabled 7α- and 7β-hydroxysteroid dehydrogenase cascade system with enhanced solubility of 7-keto-lithocholic acid. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Jeon BW – PersonEntity: Name: NameFull: Jung YJ – PersonEntity: Name: NameFull: Ryu MH – PersonEntity: Name: NameFull: Lee S – PersonEntity: Name: NameFull: Yoon J – PersonEntity: Name: NameFull: Lee EG – PersonEntity: Name: NameFull: Park JB – PersonEntity: Name: NameFull: Jang HW – PersonEntity: Name: NameFull: Hong YS – PersonEntity: Name: NameFull: Ahn J – PersonEntity: Name: NameFull: Sung BH – PersonEntity: Name: NameFull: Pandey A – PersonEntity: Name: NameFull: Song BK – PersonEntity: Name: NameFull: Park K – PersonEntity: Name: NameFull: Won W – PersonEntity: Name: NameFull: Joo JC IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 01 Text: 2026 Jan Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 1879-0003 Numbering: – Type: volume Value: 337 – Type: issue Value: Pt 2 Titles: – TitleFull: International journal of biological macromolecules Type: main |
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