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Urothelium marker UPK2 identifies aggressive colorectal cancers with distinct molecular and histological features.

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Title: Urothelium marker UPK2 identifies aggressive colorectal cancers with distinct molecular and histological features.
Authors: Äijälä VK; Translational Medicine Research Unit, University of Oulu, and Medical Research Center Oulu, Oulu University Hospital, Oulu, Finland., Härkönen J; Department of Pathology, Hospital Nova of Central Finland, Well Being Services County of Central Finland, Jyväskylä, Finland.; Faculty of Health Sciences, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland., Sirniö P; Translational Medicine Research Unit, University of Oulu, and Medical Research Center Oulu, Oulu University Hospital, Oulu, Finland., Mantere T; Laboratory of Cancer Genetics and Tumor Biology, Translational Medicine Research Unit, Medical Research Center Oulu and Biocenter Oulu, University of Oulu, Oulu, Finland., Elomaa H; Research Program in Systems Oncology, University of Helsinki, Helsinki, Finland., Sirkiä O; Department of Environmental and Biological Sciences, University of Eastern Finland, Kuopio, Finland., Kehusmaa A; Translational Medicine Research Unit, University of Oulu, and Medical Research Center Oulu, Oulu University Hospital, Oulu, Finland., Karjalainen H; Translational Medicine Research Unit, University of Oulu, and Medical Research Center Oulu, Oulu University Hospital, Oulu, Finland., Kastinen M; Translational Medicine Research Unit, University of Oulu, and Medical Research Center Oulu, Oulu University Hospital, Oulu, Finland., Tapiainen VV; Translational Medicine Research Unit, University of Oulu, and Medical Research Center Oulu, Oulu University Hospital, Oulu, Finland., Ahtiainen M; Central Finland Biobank, Hospital Nova of Central Finland, Well Being Services County of Central Finland, Jyväskylä, Finland., Helminen O; Translational Medicine Research Unit, University of Oulu, and Medical Research Center Oulu, Oulu University Hospital, Oulu, Finland.; Department of Surgery, Oulu University Hospital, Oulu, Finland., Wirta EV; Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Tampere, Finland.; Faculty of Medicine and Health Technology, Tampere University and Tays Cancer Centre, Tampere University Hospital, Tampere, Finland., Rintala J; Translational Medicine Research Unit, University of Oulu, and Medical Research Center Oulu, Oulu University Hospital, Oulu, Finland.; Department of Surgery, Oulu University Hospital, Oulu, Finland., Meriläinen S; Translational Medicine Research Unit, University of Oulu, and Medical Research Center Oulu, Oulu University Hospital, Oulu, Finland.; Department of Surgery, Oulu University Hospital, Oulu, Finland., Saarnio J; Translational Medicine Research Unit, University of Oulu, and Medical Research Center Oulu, Oulu University Hospital, Oulu, Finland.; Department of Surgery, Oulu University Hospital, Oulu, Finland., Rautio T; Translational Medicine Research Unit, University of Oulu, and Medical Research Center Oulu, Oulu University Hospital, Oulu, Finland.; Department of Surgery, Oulu University Hospital, Oulu, Finland., Seppälä TT; Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Tampere, Finland.; Faculty of Medicine and Health Technology, Tampere University and Tays Cancer Centre, Tampere University Hospital, Tampere, Finland.; Department of Gastrointestinal Surgery, Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland.; Applied Tumor Genomics, Research Program Unit, University of Helsinki, Helsinki, Finland., Böhm J; Department of Pathology, Hospital Nova of Central Finland, Well Being Services County of Central Finland, Jyväskylä, Finland., Mecklin JP; Department of Education and Research, Well Being Services County of Central Finland, Jyväskylä, Finland.; Faculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, Finland., Tuomisto A; Translational Medicine Research Unit, University of Oulu, and Medical Research Center Oulu, Oulu University Hospital, Oulu, Finland., Mäkinen MJ; Translational Medicine Research Unit, University of Oulu, and Medical Research Center Oulu, Oulu University Hospital, Oulu, Finland., Väyrynen JP; Translational Medicine Research Unit, University of Oulu, and Medical Research Center Oulu, Oulu University Hospital, Oulu, Finland. juha.vayrynen@oulu.fi.
Source: British journal of cancer [Br J Cancer] 2026 Feb; Vol. 134 (4), pp. 650-661. Date of Electronic Publication: 2025 Dec 11.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group on behalf of Cancer Research UK Country of Publication: England NLM ID: 0370635 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-1827 (Electronic) Linking ISSN: 00070920 NLM ISO Abbreviation: Br J Cancer Subsets: MEDLINE
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  Data: Urothelium marker UPK2 identifies aggressive colorectal cancers with distinct molecular and histological features.
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  Data: <searchLink fieldCode="AU" term="%22Äijälä+VK%22">Äijälä VK</searchLink>; Translational Medicine Research Unit, University of Oulu, and Medical Research Center Oulu, Oulu University Hospital, Oulu, Finland.<br /><searchLink fieldCode="AU" term="%22Härkönen+J%22">Härkönen J</searchLink>; Department of Pathology, Hospital Nova of Central Finland, Well Being Services County of Central Finland, Jyväskylä, Finland.; Faculty of Health Sciences, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.<br /><searchLink fieldCode="AU" term="%22Sirniö+P%22">Sirniö P</searchLink>; Translational Medicine Research Unit, University of Oulu, and Medical Research Center Oulu, Oulu University Hospital, Oulu, Finland.<br /><searchLink fieldCode="AU" term="%22Mantere+T%22">Mantere T</searchLink>; Laboratory of Cancer Genetics and Tumor Biology, Translational Medicine Research Unit, Medical Research Center Oulu and Biocenter Oulu, University of Oulu, Oulu, Finland.<br /><searchLink fieldCode="AU" term="%22Elomaa+H%22">Elomaa H</searchLink>; Research Program in Systems Oncology, University of Helsinki, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Sirkiä+O%22">Sirkiä O</searchLink>; Department of Environmental and Biological Sciences, University of Eastern Finland, Kuopio, Finland.<br /><searchLink fieldCode="AU" term="%22Kehusmaa+A%22">Kehusmaa A</searchLink>; Translational Medicine Research Unit, University of Oulu, and Medical Research Center Oulu, Oulu University Hospital, Oulu, Finland.<br /><searchLink fieldCode="AU" term="%22Karjalainen+H%22">Karjalainen H</searchLink>; Translational Medicine Research Unit, University of Oulu, and Medical Research Center Oulu, Oulu University Hospital, Oulu, Finland.<br /><searchLink fieldCode="AU" term="%22Kastinen+M%22">Kastinen M</searchLink>; Translational Medicine Research Unit, University of Oulu, and Medical Research Center Oulu, Oulu University Hospital, Oulu, Finland.<br /><searchLink fieldCode="AU" term="%22Tapiainen+VV%22">Tapiainen VV</searchLink>; Translational Medicine Research Unit, University of Oulu, and Medical Research Center Oulu, Oulu University Hospital, Oulu, Finland.<br /><searchLink fieldCode="AU" term="%22Ahtiainen+M%22">Ahtiainen M</searchLink>; Central Finland Biobank, Hospital Nova of Central Finland, Well Being Services County of Central Finland, Jyväskylä, Finland.<br /><searchLink fieldCode="AU" term="%22Helminen+O%22">Helminen O</searchLink>; Translational Medicine Research Unit, University of Oulu, and Medical Research Center Oulu, Oulu University Hospital, Oulu, Finland.; Department of Surgery, Oulu University Hospital, Oulu, Finland.<br /><searchLink fieldCode="AU" term="%22Wirta+EV%22">Wirta EV</searchLink>; Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Tampere, Finland.; Faculty of Medicine and Health Technology, Tampere University and Tays Cancer Centre, Tampere University Hospital, Tampere, Finland.<br /><searchLink fieldCode="AU" term="%22Rintala+J%22">Rintala J</searchLink>; Translational Medicine Research Unit, University of Oulu, and Medical Research Center Oulu, Oulu University Hospital, Oulu, Finland.; Department of Surgery, Oulu University Hospital, Oulu, Finland.<br /><searchLink fieldCode="AU" term="%22Meriläinen+S%22">Meriläinen S</searchLink>; Translational Medicine Research Unit, University of Oulu, and Medical Research Center Oulu, Oulu University Hospital, Oulu, Finland.; Department of Surgery, Oulu University Hospital, Oulu, Finland.<br /><searchLink fieldCode="AU" term="%22Saarnio+J%22">Saarnio J</searchLink>; Translational Medicine Research Unit, University of Oulu, and Medical Research Center Oulu, Oulu University Hospital, Oulu, Finland.; Department of Surgery, Oulu University Hospital, Oulu, Finland.<br /><searchLink fieldCode="AU" term="%22Rautio+T%22">Rautio T</searchLink>; Translational Medicine Research Unit, University of Oulu, and Medical Research Center Oulu, Oulu University Hospital, Oulu, Finland.; Department of Surgery, Oulu University Hospital, Oulu, Finland.<br /><searchLink fieldCode="AU" term="%22Seppälä+TT%22">Seppälä TT</searchLink>; Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Tampere, Finland.; Faculty of Medicine and Health Technology, Tampere University and Tays Cancer Centre, Tampere University Hospital, Tampere, Finland.; Department of Gastrointestinal Surgery, Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland.; Applied Tumor Genomics, Research Program Unit, University of Helsinki, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Böhm+J%22">Böhm J</searchLink>; Department of Pathology, Hospital Nova of Central Finland, Well Being Services County of Central Finland, Jyväskylä, Finland.<br /><searchLink fieldCode="AU" term="%22Mecklin+JP%22">Mecklin JP</searchLink>; Department of Education and Research, Well Being Services County of Central Finland, Jyväskylä, Finland.; Faculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, Finland.<br /><searchLink fieldCode="AU" term="%22Tuomisto+A%22">Tuomisto A</searchLink>; Translational Medicine Research Unit, University of Oulu, and Medical Research Center Oulu, Oulu University Hospital, Oulu, Finland.<br /><searchLink fieldCode="AU" term="%22Mäkinen+MJ%22">Mäkinen MJ</searchLink>; Translational Medicine Research Unit, University of Oulu, and Medical Research Center Oulu, Oulu University Hospital, Oulu, Finland.<br /><searchLink fieldCode="AU" term="%22Väyrynen+JP%22">Väyrynen JP</searchLink>; Translational Medicine Research Unit, University of Oulu, and Medical Research Center Oulu, Oulu University Hospital, Oulu, Finland. juha.vayrynen@oulu.fi.
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  Data: <searchLink fieldCode="JN" term="%220370635%22">British journal of cancer</searchLink> [Br J Cancer] 2026 Feb; Vol. 134 (4), pp. 650-661. <i>Date of Electronic Publication: </i>2025 Dec 11.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group+on+behalf+of+Cancer+Research+UK%22">Nature Publishing Group on behalf of Cancer Research UK </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>0370635 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1532-1827 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200070920%22">00070920 </searchLink><i>NLM ISO Abbreviation: </i>Br J Cancer <i>Subsets: </i>MEDLINE
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