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Blood-brain barrier water exchange in relation to amyloid, cognition and cerebrovascular burden.

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Title: Blood-brain barrier water exchange in relation to amyloid, cognition and cerebrovascular burden.
Authors: Padrela BE; Department of Radiology and Nuclear Medicine, Amsterdam University Medical Center, Location VUmc, Amsterdam, the Netherlands; Brain Imaging, Amsterdam Neuroscience, Amsterdam, the Netherlands., Tecelão S; Department of Neurology, Akershus University Hospital, Oslo, Norway., Kirsebom BE; Department of Neurology, Akershus University Hospital, Oslo, Norway; Department of Neurology, University Hospital of North Norway, Tromsø, Norway; Department of Psychology, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø, Norway., Geier O; Computational Radiology and Artificial Intelligence, Division of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway; Center for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway., Tranfa M; Department of Radiology and Nuclear Medicine, Amsterdam University Medical Center, Location VUmc, Amsterdam, the Netherlands; Brain Imaging, Amsterdam Neuroscience, Amsterdam, the Netherlands., Masserini F; Department of Radiology and Nuclear Medicine, Amsterdam University Medical Center, Location VUmc, Amsterdam, the Netherlands; Brain Imaging, Amsterdam Neuroscience, Amsterdam, the Netherlands., Sneve MH; Center for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway., Slivka M; Center for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway., Falch ES; Center for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway., Pålhaugen L; Department of Neurology, Akershus University Hospital, Oslo, Norway; Institute of Clinical Medicine, Campus Ahus, University of Oslo, Oslo, Norway., Mahroo A; Fraunhofer-Institute for Digital Medicine MEVIS, Bremen, Germany., Eickel K; Fraunhofer-Institute for Digital Medicine MEVIS, Bremen, Germany; Bremerhaven University of Applied Sciences, Bremerhaven, Germany., Thomas DL; Department of Brain Repair and Rehabilitation, UCL Queen Square Institute of Neurology, University College London, London, UK., Günther M; Fraunhofer-Institute for Digital Medicine MEVIS, Bremen, Germany; Centre for Medical Image Computing (CMIC), University College London, London, UK; MR-Imaging and Spectroscopy, University of Bremen, Bremen, Germany; mediri GmbH, Heidelberg, Germany., Selnes P; Department of Neurology, Akershus University Hospital, Oslo, Norway., Bjørnerud A; Computational Radiology and Artificial Intelligence, Division of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway; Center for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway., Walhovd KB; Computational Radiology and Artificial Intelligence, Division of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway; Center for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway., Fjell AM; Computational Radiology and Artificial Intelligence, Division of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway; Center for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway., Barkhof F; Department of Radiology and Nuclear Medicine, Amsterdam University Medical Center, Location VUmc, Amsterdam, the Netherlands; Brain Imaging, Amsterdam Neuroscience, Amsterdam, the Netherlands; Department of Brain Repair and Rehabilitation, UCL Queen Square Institute of Neurology, University College London, London, UK; Centre for Medical Image Computing (CMIC), University College London, London, UK., Petr J; Department of Radiology and Nuclear Medicine, Amsterdam University Medical Center, Location VUmc, Amsterdam, the Netherlands; Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, Dresden, Germany., Fladby T; Department of Neurology, Akershus University Hospital, Oslo, Norway; Institute of Clinical Medicine, Campus Ahus, University of Oslo, Oslo, Norway., Mutsaerts HJMM; Department of Radiology and Nuclear Medicine, Amsterdam University Medical Center, Location VUmc, Amsterdam, the Netherlands; Brain Imaging, Amsterdam Neuroscience, Amsterdam, the Netherlands. Electronic address: h.j.mutsaerts@amsterdamumc.nl.
Source: NeuroImage. Clinical [Neuroimage Clin] 2026; Vol. 49, pp. 103926. Date of Electronic Publication: 2025 Dec 11.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101597070 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2213-1582 (Electronic) Linking ISSN: 22131582 NLM ISO Abbreviation: Neuroimage Clin Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Padrela+BE%22">Padrela BE</searchLink>; Department of Radiology and Nuclear Medicine, Amsterdam University Medical Center, Location VUmc, Amsterdam, the Netherlands; Brain Imaging, Amsterdam Neuroscience, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Tecelão+S%22">Tecelão S</searchLink>; Department of Neurology, Akershus University Hospital, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Kirsebom+BE%22">Kirsebom BE</searchLink>; Department of Neurology, Akershus University Hospital, Oslo, Norway; Department of Neurology, University Hospital of North Norway, Tromsø, Norway; Department of Psychology, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø, Norway.<br /><searchLink fieldCode="AU" term="%22Geier+O%22">Geier O</searchLink>; Computational Radiology and Artificial Intelligence, Division of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway; Center for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Tranfa+M%22">Tranfa M</searchLink>; Department of Radiology and Nuclear Medicine, Amsterdam University Medical Center, Location VUmc, Amsterdam, the Netherlands; Brain Imaging, Amsterdam Neuroscience, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Masserini+F%22">Masserini F</searchLink>; Department of Radiology and Nuclear Medicine, Amsterdam University Medical Center, Location VUmc, Amsterdam, the Netherlands; Brain Imaging, Amsterdam Neuroscience, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Sneve+MH%22">Sneve MH</searchLink>; Center for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Slivka+M%22">Slivka M</searchLink>; Center for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Falch+ES%22">Falch ES</searchLink>; Center for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Pålhaugen+L%22">Pålhaugen L</searchLink>; Department of Neurology, Akershus University Hospital, Oslo, Norway; Institute of Clinical Medicine, Campus Ahus, University of Oslo, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Mahroo+A%22">Mahroo A</searchLink>; Fraunhofer-Institute for Digital Medicine MEVIS, Bremen, Germany.<br /><searchLink fieldCode="AU" term="%22Eickel+K%22">Eickel K</searchLink>; Fraunhofer-Institute for Digital Medicine MEVIS, Bremen, Germany; Bremerhaven University of Applied Sciences, Bremerhaven, Germany.<br /><searchLink fieldCode="AU" term="%22Thomas+DL%22">Thomas DL</searchLink>; Department of Brain Repair and Rehabilitation, UCL Queen Square Institute of Neurology, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Günther+M%22">Günther M</searchLink>; Fraunhofer-Institute for Digital Medicine MEVIS, Bremen, Germany; Centre for Medical Image Computing (CMIC), University College London, London, UK; MR-Imaging and Spectroscopy, University of Bremen, Bremen, Germany; mediri GmbH, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Selnes+P%22">Selnes P</searchLink>; Department of Neurology, Akershus University Hospital, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Bjørnerud+A%22">Bjørnerud A</searchLink>; Computational Radiology and Artificial Intelligence, Division of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway; Center for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Walhovd+KB%22">Walhovd KB</searchLink>; Computational Radiology and Artificial Intelligence, Division of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway; Center for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Fjell+AM%22">Fjell AM</searchLink>; Computational Radiology and Artificial Intelligence, Division of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway; Center for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Barkhof+F%22">Barkhof F</searchLink>; Department of Radiology and Nuclear Medicine, Amsterdam University Medical Center, Location VUmc, Amsterdam, the Netherlands; Brain Imaging, Amsterdam Neuroscience, Amsterdam, the Netherlands; Department of Brain Repair and Rehabilitation, UCL Queen Square Institute of Neurology, University College London, London, UK; Centre for Medical Image Computing (CMIC), University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Petr+J%22">Petr J</searchLink>; Department of Radiology and Nuclear Medicine, Amsterdam University Medical Center, Location VUmc, Amsterdam, the Netherlands; Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Fladby+T%22">Fladby T</searchLink>; Department of Neurology, Akershus University Hospital, Oslo, Norway; Institute of Clinical Medicine, Campus Ahus, University of Oslo, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Mutsaerts+HJMM%22">Mutsaerts HJMM</searchLink>; Department of Radiology and Nuclear Medicine, Amsterdam University Medical Center, Location VUmc, Amsterdam, the Netherlands; Brain Imaging, Amsterdam Neuroscience, Amsterdam, the Netherlands. Electronic address: h.j.mutsaerts@amsterdamumc.nl.
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