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Galectin-1 induces macrophage immunometabolic reprogramming, modulates T cell immunity and attenuates atherosclerotic plaque formation.

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Title: Galectin-1 induces macrophage immunometabolic reprogramming, modulates T cell immunity and attenuates atherosclerotic plaque formation.
Authors: Li Y; Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-Universität, University Hospital, Munich, Germany., Leberzammer J; Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-Universität, University Hospital, Munich, Germany; Goethe University Hospital, Department of Medicine, Cardiology, Frankfurt, Germany., Blanchet X; Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-Universität, University Hospital, Munich, Germany., Duan R; Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-Universität, University Hospital, Munich, Germany., Lacy M; Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-Universität, University Hospital, Munich, Germany; Department of Medical Laboratory Sciences, Virginia Commonwealth University, Richmond, VA, USA., Triantafyllidou V; Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-Universität, University Hospital, Munich, Germany., Eckardt V; Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-Universität, University Hospital, Munich, Germany; Stanford Cardiovascular Institute, Stanford University, Stanford, CA, USA; Department of Medicine I, University Hospital, Ludwig-Maximilians-Universität, Munich, Germany., Briem E; Anthropology and Human Genomics, Faculty of Biology, Ludwig-Maximilians-Universität, Munich, Germany., Jung AS; Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-Universität, University Hospital, Munich, Germany., Su R; Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-Universität, University Hospital, Munich, Germany., Guerra J; Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-Universität, University Hospital, Munich, Germany; Institute for Diabetes and Cancer (IDC), Helmholtz Center Munich, Neuherberg, Germany., Jansen Y; Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-Universität, University Hospital, Munich, Germany., Hristov M; Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-Universität, University Hospital, Munich, Germany., Enard W; Anthropology and Human Genomics, Faculty of Biology, Ludwig-Maximilians-Universität, Munich, Germany., Bernhagen J; Institute for Stroke and Dementia Research, Ludwig-Maximilians-Universität, University Hospital, Munich, Germany; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany; German Centre for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany., Weber C; Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-Universität, University Hospital, Munich, Germany; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany; Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Centre, Maastricht, the Netherlands; German Centre for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany., Atzler D; Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-Universität, University Hospital, Munich, Germany; Walter Straub Institute of Pharmacology and Toxicology, Ludwig-Maximilians-Universität, Munich, Germany., Bartelt A; Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-Universität, University Hospital, Munich, Germany; Else Kröner Fresenius Center for Nutritional Medicine, Technical University of Munich, 85354 Munich, Germany., Döring Y; Division of Angiology, Swiss Cardiovascular Center, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland., Santovito D; Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-Universität, University Hospital, Munich, Germany; German Centre for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany., Kaltner H; Department of Veterinary Sciences, Biochemistry and Chemistry, Ludwig-Maximilians-Universität, Munich, Germany., Ludwig AK; Department of Veterinary Sciences, Biochemistry and Chemistry, Ludwig-Maximilians-Universität, Munich, Germany., von Hundelshausen P; Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-Universität, University Hospital, Munich, Germany; German Centre for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany. Electronic address: phundels@med.lmu.de.
Source: Atherosclerosis [Atherosclerosis] 2026 Feb; Vol. 413, pp. 120608. Date of Electronic Publication: 2025 Dec 04.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: Ireland NLM ID: 0242543 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1484 (Electronic) Linking ISSN: 00219150 NLM ISO Abbreviation: Atherosclerosis Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Galectin-1 induces macrophage immunometabolic reprogramming, modulates T cell immunity and attenuates atherosclerotic plaque formation.
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  Data: <searchLink fieldCode="AU" term="%22Li+Y%22">Li Y</searchLink>; Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-Universität, University Hospital, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Leberzammer+J%22">Leberzammer J</searchLink>; Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-Universität, University Hospital, Munich, Germany; Goethe University Hospital, Department of Medicine, Cardiology, Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Blanchet+X%22">Blanchet X</searchLink>; Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-Universität, University Hospital, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Duan+R%22">Duan R</searchLink>; Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-Universität, University Hospital, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Lacy+M%22">Lacy M</searchLink>; Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-Universität, University Hospital, Munich, Germany; Department of Medical Laboratory Sciences, Virginia Commonwealth University, Richmond, VA, USA.<br /><searchLink fieldCode="AU" term="%22Triantafyllidou+V%22">Triantafyllidou V</searchLink>; Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-Universität, University Hospital, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Eckardt+V%22">Eckardt V</searchLink>; Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-Universität, University Hospital, Munich, Germany; Stanford Cardiovascular Institute, Stanford University, Stanford, CA, USA; Department of Medicine I, University Hospital, Ludwig-Maximilians-Universität, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Briem+E%22">Briem E</searchLink>; Anthropology and Human Genomics, Faculty of Biology, Ludwig-Maximilians-Universität, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Jung+AS%22">Jung AS</searchLink>; Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-Universität, University Hospital, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Su+R%22">Su R</searchLink>; Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-Universität, University Hospital, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Guerra+J%22">Guerra J</searchLink>; Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-Universität, University Hospital, Munich, Germany; Institute for Diabetes and Cancer (IDC), Helmholtz Center Munich, Neuherberg, Germany.<br /><searchLink fieldCode="AU" term="%22Jansen+Y%22">Jansen Y</searchLink>; Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-Universität, University Hospital, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Hristov+M%22">Hristov M</searchLink>; Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-Universität, University Hospital, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Enard+W%22">Enard W</searchLink>; Anthropology and Human Genomics, Faculty of Biology, Ludwig-Maximilians-Universität, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Bernhagen+J%22">Bernhagen J</searchLink>; Institute for Stroke and Dementia Research, Ludwig-Maximilians-Universität, University Hospital, Munich, Germany; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany; German Centre for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Weber+C%22">Weber C</searchLink>; Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-Universität, University Hospital, Munich, Germany; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany; Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Centre, Maastricht, the Netherlands; German Centre for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Atzler+D%22">Atzler D</searchLink>; Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-Universität, University Hospital, Munich, Germany; Walter Straub Institute of Pharmacology and Toxicology, Ludwig-Maximilians-Universität, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Bartelt+A%22">Bartelt A</searchLink>; Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-Universität, University Hospital, Munich, Germany; Else Kröner Fresenius Center for Nutritional Medicine, Technical University of Munich, 85354 Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Döring+Y%22">Döring Y</searchLink>; Division of Angiology, Swiss Cardiovascular Center, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.<br /><searchLink fieldCode="AU" term="%22Santovito+D%22">Santovito D</searchLink>; Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-Universität, University Hospital, Munich, Germany; German Centre for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Kaltner+H%22">Kaltner H</searchLink>; Department of Veterinary Sciences, Biochemistry and Chemistry, Ludwig-Maximilians-Universität, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Ludwig+AK%22">Ludwig AK</searchLink>; Department of Veterinary Sciences, Biochemistry and Chemistry, Ludwig-Maximilians-Universität, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22von+Hundelshausen+P%22">von Hundelshausen P</searchLink>; Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-Universität, University Hospital, Munich, Germany; German Centre for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany. Electronic address: phundels@med.lmu.de.
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  Data: <searchLink fieldCode="JN" term="%220242543%22">Atherosclerosis</searchLink> [Atherosclerosis] 2026 Feb; Vol. 413, pp. 120608. <i>Date of Electronic Publication: </i>2025 Dec 04.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>Ireland <i>NLM ID: </i>0242543 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1879-1484 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200219150%22">00219150 </searchLink><i>NLM ISO Abbreviation: </i>Atherosclerosis <i>Subsets: </i>MEDLINE
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