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Organoid platinum-resistance model identifies KRT17 as a biomarker of targeted therapy in ovarian cancer.

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Title: Organoid platinum-resistance model identifies KRT17 as a biomarker of targeted therapy in ovarian cancer.
Authors: Reichenbach J; Department of Obstetrics and Gynecology, University Hospital, Ludwig-Maximilians-University Munich, 81377 Munich, Germany.; Bavarian Cancer Research Center (BZKF), 81377 Munich, Germany., Schmid J; Department of Obstetrics and Gynecology, University Hospital, Ludwig-Maximilians-University Munich, 81377 Munich, Germany., Hierlmayer S; Department of Obstetrics and Gynecology, University Hospital, Ludwig-Maximilians-University Munich, 81377 Munich, Germany., Zhang T; Department of Obstetrics and Gynecology, University Hospital, Ludwig-Maximilians-University Munich, 81377 Munich, Germany., Piga I; Proteomics Program, Faculty of Health and Medical Sciences, Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, 2200 Copenhagen, Denmark., Geweniger S; Department of Obstetrics and Gynecology, University Hospital, Ludwig-Maximilians-University Munich, 81377 Munich, Germany.; German Cancer Consortium, DKTK, Partner Site Munich, 69120 Heidelberg, Germany., Fischer J; Department of Obstetrics and Gynecology, University Hospital, Ludwig-Maximilians-University Munich, 81377 Munich, Germany., Davesar A; Department of Obstetrics and Gynecology, University Hospital, Ludwig-Maximilians-University Munich, 81377 Munich, Germany., Vasovic N; Department of Obstetrics and Gynecology, University Hospital, Ludwig-Maximilians-University Munich, 81377 Munich, Germany., Chelariu-Raicu A; Department of Obstetrics and Gynecology, University Hospital, Ludwig-Maximilians-University Munich, 81377 Munich, Germany.; Bavarian Cancer Research Center (BZKF), 81377 Munich, Germany.; German Cancer Consortium, DKTK, Partner Site Munich, 69120 Heidelberg, Germany., Kraus F; Department of Obstetrics and Gynecology, University Hospital, Ludwig-Maximilians-University Munich, 81377 Munich, Germany., Burges A; Department of Obstetrics and Gynecology, University Hospital, Ludwig-Maximilians-University Munich, 81377 Munich, Germany., Czogalla B; Department of Obstetrics and Gynecology, University Hospital, Ludwig-Maximilians-University Munich, 81377 Munich, Germany.; German Cancer Consortium, DKTK, Partner Site Munich, 69120 Heidelberg, Germany., Mayr D; Department of Pathology, LMU Munich, 80337 Munich, Germany., Straub T; Bioinformatics Unit, Biomedical Center, LMU Munich, 82152 Martinsried, Germany., Klein C; Department of Pediatrics, Dr. Von Hauner Children's Hospital, University Hospital, Ludwig-Maximilians-University Munich, 80337 Munich, Germany., Olsen JV; Proteomics Program, Faculty of Health and Medical Sciences, Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, 2200 Copenhagen, Denmark., Mahner S; Department of Obstetrics and Gynecology, University Hospital, Ludwig-Maximilians-University Munich, 81377 Munich, Germany.; Bavarian Cancer Research Center (BZKF), 81377 Munich, Germany.; German Cancer Consortium, DKTK, Partner Site Munich, 69120 Heidelberg, Germany., Trillsch F; Department of Obstetrics and Gynecology, University Hospital, Ludwig-Maximilians-University Munich, 81377 Munich, Germany.; Bavarian Cancer Research Center (BZKF), 81377 Munich, Germany.; German Cancer Consortium, DKTK, Partner Site Munich, 69120 Heidelberg, Germany., Kessler M; Department of Obstetrics and Gynecology, University Hospital, Ludwig-Maximilians-University Munich, 81377 Munich, Germany.; Bavarian Cancer Research Center (BZKF), 81377 Munich, Germany.; German Cancer Consortium, DKTK, Partner Site Munich, 69120 Heidelberg, Germany.
Source: IScience [iScience] 2025 Nov 10; Vol. 28 (12), pp. 113999. Date of Electronic Publication: 2025 Nov 10 (Print Publication: 2025).
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101724038 Publication Model: eCollection Cited Medium: Internet ISSN: 2589-0042 (Electronic) Linking ISSN: 25890042 NLM ISO Abbreviation: iScience Subsets: PubMed not MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Reichenbach+J%22">Reichenbach J</searchLink>; Department of Obstetrics and Gynecology, University Hospital, Ludwig-Maximilians-University Munich, 81377 Munich, Germany.; Bavarian Cancer Research Center (BZKF), 81377 Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Schmid+J%22">Schmid J</searchLink>; Department of Obstetrics and Gynecology, University Hospital, Ludwig-Maximilians-University Munich, 81377 Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Hierlmayer+S%22">Hierlmayer S</searchLink>; Department of Obstetrics and Gynecology, University Hospital, Ludwig-Maximilians-University Munich, 81377 Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Zhang+T%22">Zhang T</searchLink>; Department of Obstetrics and Gynecology, University Hospital, Ludwig-Maximilians-University Munich, 81377 Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Piga+I%22">Piga I</searchLink>; Proteomics Program, Faculty of Health and Medical Sciences, Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, 2200 Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Geweniger+S%22">Geweniger S</searchLink>; Department of Obstetrics and Gynecology, University Hospital, Ludwig-Maximilians-University Munich, 81377 Munich, Germany.; German Cancer Consortium, DKTK, Partner Site Munich, 69120 Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Fischer+J%22">Fischer J</searchLink>; Department of Obstetrics and Gynecology, University Hospital, Ludwig-Maximilians-University Munich, 81377 Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Davesar+A%22">Davesar A</searchLink>; Department of Obstetrics and Gynecology, University Hospital, Ludwig-Maximilians-University Munich, 81377 Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Vasovic+N%22">Vasovic N</searchLink>; Department of Obstetrics and Gynecology, University Hospital, Ludwig-Maximilians-University Munich, 81377 Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Chelariu-Raicu+A%22">Chelariu-Raicu A</searchLink>; Department of Obstetrics and Gynecology, University Hospital, Ludwig-Maximilians-University Munich, 81377 Munich, Germany.; Bavarian Cancer Research Center (BZKF), 81377 Munich, Germany.; German Cancer Consortium, DKTK, Partner Site Munich, 69120 Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Kraus+F%22">Kraus F</searchLink>; Department of Obstetrics and Gynecology, University Hospital, Ludwig-Maximilians-University Munich, 81377 Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Burges+A%22">Burges A</searchLink>; Department of Obstetrics and Gynecology, University Hospital, Ludwig-Maximilians-University Munich, 81377 Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Czogalla+B%22">Czogalla B</searchLink>; Department of Obstetrics and Gynecology, University Hospital, Ludwig-Maximilians-University Munich, 81377 Munich, Germany.; German Cancer Consortium, DKTK, Partner Site Munich, 69120 Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Mayr+D%22">Mayr D</searchLink>; Department of Pathology, LMU Munich, 80337 Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Straub+T%22">Straub T</searchLink>; Bioinformatics Unit, Biomedical Center, LMU Munich, 82152 Martinsried, Germany.<br /><searchLink fieldCode="AU" term="%22Klein+C%22">Klein C</searchLink>; Department of Pediatrics, Dr. Von Hauner Children's Hospital, University Hospital, Ludwig-Maximilians-University Munich, 80337 Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Olsen+JV%22">Olsen JV</searchLink>; Proteomics Program, Faculty of Health and Medical Sciences, Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, 2200 Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Mahner+S%22">Mahner S</searchLink>; Department of Obstetrics and Gynecology, University Hospital, Ludwig-Maximilians-University Munich, 81377 Munich, Germany.; Bavarian Cancer Research Center (BZKF), 81377 Munich, Germany.; German Cancer Consortium, DKTK, Partner Site Munich, 69120 Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Trillsch+F%22">Trillsch F</searchLink>; Department of Obstetrics and Gynecology, University Hospital, Ludwig-Maximilians-University Munich, 81377 Munich, Germany.; Bavarian Cancer Research Center (BZKF), 81377 Munich, Germany.; German Cancer Consortium, DKTK, Partner Site Munich, 69120 Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Kessler+M%22">Kessler M</searchLink>; Department of Obstetrics and Gynecology, University Hospital, Ludwig-Maximilians-University Munich, 81377 Munich, Germany.; Bavarian Cancer Research Center (BZKF), 81377 Munich, Germany.; German Cancer Consortium, DKTK, Partner Site Munich, 69120 Heidelberg, Germany.
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