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Metformin diminishes lipopolysaccharide-induced endotoxemia and cardiopulmonary microvascular coagulopathy: Molecular insights on vascular endothelial growth factor-A and its receptors.

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Title: Metformin diminishes lipopolysaccharide-induced endotoxemia and cardiopulmonary microvascular coagulopathy: Molecular insights on vascular endothelial growth factor-A and its receptors.
Authors: Elkholy SE; Department of Pharmacology, Faculty of Medicine, Port Said University, Port Said, Egypt; Faculty of Medicine, East Port Said National University, Port Said, Egypt. Electronic address: sherin.kholy@med.psu.edu.eg., Mostafa EMA; Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Suez Canal University, 41522 Ismailia, Egypt. Electronic address: enas_mostafa@med.suez.edu.eg., Ameen AM; Department of Physiology, Faculty of Medicine, Suez Canal University, 41522 Ismailia, Egypt; Center of excellence in cellular and molecular medicine, Faculty of Medicine, Suez Canal University, 41522 Ismailia, Egypt. Electronic address: angie_ameen@med.suez.edu.eg., Abdelaziz EZ; Department of Clinical Pharmacology, Faculty of Medicine, Suez Canal University, 41522 Ismailia, Egypt; Department of Pharmacology, Faculty of Medicine, Delta University for Science and Technology, Egypt. Electronic address: emanzakareya@med.suez.edu.eg., Hamed ER; Department of Chest Diseases (Internal Medicine), Faculty of Medicine, Suez Canal University, 41522 Ismailia, Egypt. Electronic address: emanriad@med.suez.edu.eg., El-Kherbetawy MK; Department of Pathology, Faculty of Medicine, Suez Canal University, 41522 Ismailia, Egypt; King Fahad Military Medical Complex, Ministry of Defense Health Services, Dhahran, Saudi Arabia. Electronic address: mohamed_elkherbetawy@med.suez.edu.eg., Elsayed HA; Department of Microbiology, Faculty of Medicine, Port Said University, Port Said, Egypt. Electronic address: heba.elsayed@med.psu.edu.eg., Atta R; Department of Physiology, Faculty of Medicine, Suez Canal University, 41522 Ismailia, Egypt; Center of excellence in cellular and molecular medicine, Faculty of Medicine, Suez Canal University, 41522 Ismailia, Egypt. Electronic address: rasha_atta@med.suez.edu.eg., Abdelfatah W; Department of Chest Diseases (Internal Medicine), Faculty of Medicine, Suez Canal University, 41522 Ismailia, Egypt., Mehana AE; Department of Zoology, Faculty of Science, Suez Canal University, 41522 Ismailia, Egypt. Electronic address: amirelsayed@science.suez.edu.eg., Tantawy MA; Hormones Department, Medical Research and Clinical Studies Institute, National Research Centre, Dokki, Cairo 12622, Egypt; Faculty of Health sciences Sharjah Campus, Higher Colleges of Technology, United Arab Emirates. Electronic address: mtantawy@hct.ac.ae., Mahran RI; Department of Clinical Pharmacology, Faculty of Medicine, Suez Canal University, 41522 Ismailia, Egypt. Electronic address: Ramaibrahim@med.Suez.edu.eg., Elaidy SM; Department of Clinical Pharmacology, Faculty of Medicine, Suez Canal University, 41522 Ismailia, Egypt; Department of Pharmacology, Faculty of Medicine, Delta University for Science and Technology, Egypt. Electronic address: samah_elaidi@med.suez.edu.eg.
Source: International immunopharmacology [Int Immunopharmacol] 2026 Jan 15; Vol. 169, pp. 116036. Date of Electronic Publication: 2025 Dec 15.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 100965259 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-1705 (Electronic) Linking ISSN: 15675769 NLM ISO Abbreviation: Int Immunopharmacol Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Elkholy+SE%22">Elkholy SE</searchLink>; Department of Pharmacology, Faculty of Medicine, Port Said University, Port Said, Egypt; Faculty of Medicine, East Port Said National University, Port Said, Egypt. Electronic address: sherin.kholy@med.psu.edu.eg.<br /><searchLink fieldCode="AU" term="%22Mostafa+EMA%22">Mostafa EMA</searchLink>; Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Suez Canal University, 41522 Ismailia, Egypt. Electronic address: enas_mostafa@med.suez.edu.eg.<br /><searchLink fieldCode="AU" term="%22Ameen+AM%22">Ameen AM</searchLink>; Department of Physiology, Faculty of Medicine, Suez Canal University, 41522 Ismailia, Egypt; Center of excellence in cellular and molecular medicine, Faculty of Medicine, Suez Canal University, 41522 Ismailia, Egypt. Electronic address: angie_ameen@med.suez.edu.eg.<br /><searchLink fieldCode="AU" term="%22Abdelaziz+EZ%22">Abdelaziz EZ</searchLink>; Department of Clinical Pharmacology, Faculty of Medicine, Suez Canal University, 41522 Ismailia, Egypt; Department of Pharmacology, Faculty of Medicine, Delta University for Science and Technology, Egypt. Electronic address: emanzakareya@med.suez.edu.eg.<br /><searchLink fieldCode="AU" term="%22Hamed+ER%22">Hamed ER</searchLink>; Department of Chest Diseases (Internal Medicine), Faculty of Medicine, Suez Canal University, 41522 Ismailia, Egypt. Electronic address: emanriad@med.suez.edu.eg.<br /><searchLink fieldCode="AU" term="%22El-Kherbetawy+MK%22">El-Kherbetawy MK</searchLink>; Department of Pathology, Faculty of Medicine, Suez Canal University, 41522 Ismailia, Egypt; King Fahad Military Medical Complex, Ministry of Defense Health Services, Dhahran, Saudi Arabia. Electronic address: mohamed_elkherbetawy@med.suez.edu.eg.<br /><searchLink fieldCode="AU" term="%22Elsayed+HA%22">Elsayed HA</searchLink>; Department of Microbiology, Faculty of Medicine, Port Said University, Port Said, Egypt. Electronic address: heba.elsayed@med.psu.edu.eg.<br /><searchLink fieldCode="AU" term="%22Atta+R%22">Atta R</searchLink>; Department of Physiology, Faculty of Medicine, Suez Canal University, 41522 Ismailia, Egypt; Center of excellence in cellular and molecular medicine, Faculty of Medicine, Suez Canal University, 41522 Ismailia, Egypt. Electronic address: rasha_atta@med.suez.edu.eg.<br /><searchLink fieldCode="AU" term="%22Abdelfatah+W%22">Abdelfatah W</searchLink>; Department of Chest Diseases (Internal Medicine), Faculty of Medicine, Suez Canal University, 41522 Ismailia, Egypt.<br /><searchLink fieldCode="AU" term="%22Mehana+AE%22">Mehana AE</searchLink>; Department of Zoology, Faculty of Science, Suez Canal University, 41522 Ismailia, Egypt. Electronic address: amirelsayed@science.suez.edu.eg.<br /><searchLink fieldCode="AU" term="%22Tantawy+MA%22">Tantawy MA</searchLink>; Hormones Department, Medical Research and Clinical Studies Institute, National Research Centre, Dokki, Cairo 12622, Egypt; Faculty of Health sciences Sharjah Campus, Higher Colleges of Technology, United Arab Emirates. Electronic address: mtantawy@hct.ac.ae.<br /><searchLink fieldCode="AU" term="%22Mahran+RI%22">Mahran RI</searchLink>; Department of Clinical Pharmacology, Faculty of Medicine, Suez Canal University, 41522 Ismailia, Egypt. Electronic address: Ramaibrahim@med.Suez.edu.eg.<br /><searchLink fieldCode="AU" term="%22Elaidy+SM%22">Elaidy SM</searchLink>; Department of Clinical Pharmacology, Faculty of Medicine, Suez Canal University, 41522 Ismailia, Egypt; Department of Pharmacology, Faculty of Medicine, Delta University for Science and Technology, Egypt. Electronic address: samah_elaidi@med.suez.edu.eg.
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