MAT2A promotes atherosclerotic plaque vulnerability by mediating epigenetic reprogramming of macrophages.

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Title: MAT2A promotes atherosclerotic plaque vulnerability by mediating epigenetic reprogramming of macrophages.
Authors: Du Z; Department of Cardiology, the 2nd Affiliated Hospital of Harbin Medical University, Harbin, China.; The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, China., Wan P; Department of Cardiology, the 2nd Affiliated Hospital of Harbin Medical University, Harbin, China.; The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, China., Du M; Department of Cardiology, the 2nd Affiliated Hospital of Harbin Medical University, Harbin, China.; The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, China., Li S; Department of Cardiology, the 2nd Affiliated Hospital of Harbin Medical University, Harbin, China.; The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, China., Yan Q; Department of Cardiology, the 2nd Affiliated Hospital of Harbin Medical University, Harbin, China.; The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, China., Sun S; Department of Cardiology, the 2nd Affiliated Hospital of Harbin Medical University, Harbin, China.; The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, China., Tang C; Department of Cardiology, the 2nd Affiliated Hospital of Harbin Medical University, Harbin, China.; The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, China., Jiang Z; Department of Cardiology, the 2nd Affiliated Hospital of Harbin Medical University, Harbin, China.; The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, China., Li S; Department of Cardiology, the 2nd Affiliated Hospital of Harbin Medical University, Harbin, China.; The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, China., Shi G; Department of Cardiology, the 2nd Affiliated Hospital of Harbin Medical University, Harbin, China.; The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, China., Miao B; Department of Cardiology, the 2nd Affiliated Hospital of Harbin Medical University, Harbin, China.; The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, China., Du X; Department of Cardiology, the 2nd Affiliated Hospital of Harbin Medical University, Harbin, China.; The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, China., Li S; Department of Cardiology, the 2nd Affiliated Hospital of Harbin Medical University, Harbin, China.; The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, China., Fang S; Department of Cardiology, the 2nd Affiliated Hospital of Harbin Medical University, Harbin, China.; The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, China., Wang C; The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, China.; Department of Ultrasound, the 2nd Affiliated Hospital of Harbin Medical University, Harbin, China., Fang C; Department of Cardiology, the 2nd Affiliated Hospital of Harbin Medical University, Harbin, China.; The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, China., Yu B; Department of Cardiology, the 2nd Affiliated Hospital of Harbin Medical University, Harbin, China. yubodr@163.com.; The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, China. yubodr@163.com.; The State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), Harbin, China. yubodr@163.com., Dai J; Department of Cardiology, the 2nd Affiliated Hospital of Harbin Medical University, Harbin, China. daijiannandr@163.com.; The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, China. daijiannandr@163.com.; The State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), Harbin, China. daijiannandr@163.com., Sun P; The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, China. sunpinghmu@163.com.; Department of Ultrasound, the 2nd Affiliated Hospital of Harbin Medical University, Harbin, China. sunpinghmu@163.com.
Source: Nature communications [Nat Commun] 2025 Dec 16; Vol. 16 (1), pp. 11168. Date of Electronic Publication: 2025 Dec 16.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2041-1723
DOI:10.1038/s41467-025-66121-z