Using a composite end-point and WIN-ratio analysis to evaluate perineal wound healing after abdominoperineal resection for rectal cancer: further insights from the BIOPEX trials.

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Title: Using a composite end-point and WIN-ratio analysis to evaluate perineal wound healing after abdominoperineal resection for rectal cancer: further insights from the BIOPEX trials.
Authors: van den Berg R; Department of Surgery, Erasmus University Medical Center, Rotterdam, The Netherlands., Musters GD; Department of Surgery, Zaans Medical Center, Zaandam, The Netherlands., Kreisel SI; Department of Surgery, Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands.; Cancer Centre Amsterdam, Treatment and Quality of Life, Amsterdam, The Netherlands., van Gerwen N; Department of Biostatistics, Erasmus University Medical Center, Rotterdam, The Netherlands.; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands., Verhoef K; Department of Surgery, Erasmus University Medical Center, Rotterdam, The Netherlands., Tanis PJ; Department of Surgery, Erasmus University Medical Center, Rotterdam, The Netherlands., Sharabiany S; Department of Surgery, Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands.; Cancer Centre Amsterdam, Treatment and Quality of Life, Amsterdam, The Netherlands., Tuynman JB; Department of Surgery, Amsterdam UMC location VUmc, Amsterdam, The Netherlands., Hompes R; Department of Surgery, Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands.; Department of Surgery, Amsterdam UMC location VUmc, Amsterdam, The Netherlands., Belgers E; Department of Surgery, Zuyderland Medical Centre, Sittard-Geleen and Heerlen, The Netherlands., Singh B; Department of Surgery, University Hospitals Leicester, Leicester, United Kingdom., Chaudhri S; Department of Surgery, University Hospitals Leicester, Leicester, United Kingdom., van Geloven A; Department of Surgery, Tergooi Medical Centre, Hilversum, The Netherlands., Vuylsteke R; Department of Surgery, Spaarne Gasthuis, Haarlem, The Netherlands., de Wilt J; Department of Surgery, Radboud University Medical Centre, Nijmegen, The Netherlands., Melenhorst J; Department of Surgery, Maastricht University Medical Centre, Maastricht, The Netherlands., Leijtens J; Department of Surgery, St. Laurentius Hospital, Roermond, The Netherlands., Vermaas M; Department of Surgery, IJsselland Hospital, Capelle aan de IJssel, The Netherlands., Rothbarth J; Department of Surgery, Erasmus University Medical Center, Rotterdam, The Netherlands., Burger J; Department of Surgery, Catharina Hospital, Eindhoven, The Netherlands., Polat F; Department of Surgery, Canisius Wilhemina Hospital, Nijmegen, The Netherlands., Fabry H; Department of Surgery, Bravis Hospital, Bergen op Zoom, The Netherlands., Aalbers A; Surgical Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands., Wijsman JH; Department of Surgery, Amphia Hospital, Breda, The Netherlands., Lamme B; Department of Surgery, Albert Schweitzer Hospital, Dordrecht, The Netherlands., van de Ven A; Department of Surgery, Flevo Hospital, Almere, The Netherlands., Lapid O; Department of Plastic, Reconstructive and Hand Surgery, Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands., Blok R; Department of Surgery, Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands., Bosker R; Department Surgery, Deventer Hospital, Deventer, the Netherlands., van Duijvendijk P; Department of Surgery, Gelre Hospital, Apeldoorn, The Netherlands., van Etten B; Department of Surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Hoff C; Department of Surgery, Medical Center Leeuwarden, Leeuwarden, The Netherlands.
Corporate Authors: BIOPEX and BIOPEX-2 collaborators and BIOPEX and BIOPEX-2 collaborators
Source: International journal of surgery (London, England) [Int J Surg] 2025 Dec 17. Date of Electronic Publication: 2025 Dec 17.
Publication Type: Journal Article
Journal Info: Publisher: Wolters Kluwer Health, Inc Country of Publication: United States NLM ID: 101228232 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1743-9159 (Electronic) Linking ISSN: 17439159 NLM ISO Abbreviation: Int J Surg Subsets: MEDLINE
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  Data: Using a composite end-point and WIN-ratio analysis to evaluate perineal wound healing after abdominoperineal resection for rectal cancer: further insights from the BIOPEX trials.
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  Data: <searchLink fieldCode="AU" term="%22van+den+Berg+R%22">van den Berg R</searchLink>; Department of Surgery, Erasmus University Medical Center, Rotterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Musters+GD%22">Musters GD</searchLink>; Department of Surgery, Zaans Medical Center, Zaandam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Kreisel+SI%22">Kreisel SI</searchLink>; Department of Surgery, Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands.; Cancer Centre Amsterdam, Treatment and Quality of Life, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22van+Gerwen+N%22">van Gerwen N</searchLink>; Department of Biostatistics, Erasmus University Medical Center, Rotterdam, The Netherlands.; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Verhoef+K%22">Verhoef K</searchLink>; Department of Surgery, Erasmus University Medical Center, Rotterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Tanis+PJ%22">Tanis PJ</searchLink>; Department of Surgery, Erasmus University Medical Center, Rotterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Sharabiany+S%22">Sharabiany S</searchLink>; Department of Surgery, Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands.; Cancer Centre Amsterdam, Treatment and Quality of Life, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Tuynman+JB%22">Tuynman JB</searchLink>; Department of Surgery, Amsterdam UMC location VUmc, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Hompes+R%22">Hompes R</searchLink>; Department of Surgery, Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands.; Department of Surgery, Amsterdam UMC location VUmc, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Belgers+E%22">Belgers E</searchLink>; Department of Surgery, Zuyderland Medical Centre, Sittard-Geleen and Heerlen, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Singh+B%22">Singh B</searchLink>; Department of Surgery, University Hospitals Leicester, Leicester, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Chaudhri+S%22">Chaudhri S</searchLink>; Department of Surgery, University Hospitals Leicester, Leicester, United Kingdom.<br /><searchLink fieldCode="AU" term="%22van+Geloven+A%22">van Geloven A</searchLink>; Department of Surgery, Tergooi Medical Centre, Hilversum, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Vuylsteke+R%22">Vuylsteke R</searchLink>; Department of Surgery, Spaarne Gasthuis, Haarlem, The Netherlands.<br /><searchLink fieldCode="AU" term="%22de+Wilt+J%22">de Wilt J</searchLink>; Department of Surgery, Radboud University Medical Centre, Nijmegen, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Melenhorst+J%22">Melenhorst J</searchLink>; Department of Surgery, Maastricht University Medical Centre, Maastricht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Leijtens+J%22">Leijtens J</searchLink>; Department of Surgery, St. Laurentius Hospital, Roermond, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Vermaas+M%22">Vermaas M</searchLink>; Department of Surgery, IJsselland Hospital, Capelle aan de IJssel, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Rothbarth+J%22">Rothbarth J</searchLink>; Department of Surgery, Erasmus University Medical Center, Rotterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Burger+J%22">Burger J</searchLink>; Department of Surgery, Catharina Hospital, Eindhoven, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Polat+F%22">Polat F</searchLink>; Department of Surgery, Canisius Wilhemina Hospital, Nijmegen, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Fabry+H%22">Fabry H</searchLink>; Department of Surgery, Bravis Hospital, Bergen op Zoom, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Aalbers+A%22">Aalbers A</searchLink>; Surgical Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Wijsman+JH%22">Wijsman JH</searchLink>; Department of Surgery, Amphia Hospital, Breda, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Lamme+B%22">Lamme B</searchLink>; Department of Surgery, Albert Schweitzer Hospital, Dordrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22van+de+Ven+A%22">van de Ven A</searchLink>; Department of Surgery, Flevo Hospital, Almere, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Lapid+O%22">Lapid O</searchLink>; Department of Plastic, Reconstructive and Hand Surgery, Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Blok+R%22">Blok R</searchLink>; Department of Surgery, Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Bosker+R%22">Bosker R</searchLink>; Department Surgery, Deventer Hospital, Deventer, the Netherlands.<br /><searchLink fieldCode="AU" term="%22van+Duijvendijk+P%22">van Duijvendijk P</searchLink>; Department of Surgery, Gelre Hospital, Apeldoorn, The Netherlands.<br /><searchLink fieldCode="AU" term="%22van+Etten+B%22">van Etten B</searchLink>; Department of Surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Hoff+C%22">Hoff C</searchLink>; Department of Surgery, Medical Center Leeuwarden, Leeuwarden, The Netherlands.
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  Data: <searchLink fieldCode="JN" term="%22101228232%22">International journal of surgery (London, England)</searchLink> [Int J Surg] 2025 Dec 17. <i>Date of Electronic Publication: </i>2025 Dec 17.
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