View in EDS

Combining cell-free DNA fragmentomes and total tumour volume improves prognostication and tumour response evaluation in patients with colorectal cancer liver metastases.

Saved in:
Bibliographic Details
Title: Combining cell-free DNA fragmentomes and total tumour volume improves prognostication and tumour response evaluation in patients with colorectal cancer liver metastases.
Authors: Crnovrsanin N; Department of Pathology, Netherlands Cancer Institute, Amsterdam, the Netherlands; Department of General, Abdominal and Transplantation Surgery, University Hospital Heidelberg, Heidelberg, Germany., Zeeuw JM; Department of Surgery, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands; Cancer Center Amsterdam, Amsterdam, the Netherlands., Ali M; Department of Surgery, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands; Cancer Center Amsterdam, Amsterdam, the Netherlands., Kemna R; Department of Surgery, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands; Cancer Center Amsterdam, Amsterdam, the Netherlands., Alipanahi B; Delfi Diagnostics, Inc., Baltimore, MD, USA., Lumbard K; Delfi Diagnostics, Inc., Baltimore, MD, USA., Skidmore ZL; Delfi Diagnostics, Inc., Baltimore, MD, USA., Rinaldi L; Delfi Diagnostics, Inc., Baltimore, MD, USA., van 't Erve I; Department of Pathology, Netherlands Cancer Institute, Amsterdam, the Netherlands., Wesdorp NJ; Department of Surgery, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands; Cancer Center Amsterdam, Amsterdam, the Netherlands., Huiskens J; Department of Surgery, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands., van Steijn D; Department of Pathology, Netherlands Cancer Institute, Amsterdam, the Netherlands., van Waesberghe JH; Cancer Center Amsterdam, Amsterdam, the Netherlands; Department of Radiology and Nuclear Medicine, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands., van den Bergh J; Cancer Center Amsterdam, Amsterdam, the Netherlands; Department of Radiology and Nuclear Medicine, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands., Nota I; Cancer Center Amsterdam, Amsterdam, the Netherlands; Department of Radiology and Nuclear Medicine, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands., Moos S; Cancer Center Amsterdam, Amsterdam, the Netherlands; Department of Radiology and Nuclear Medicine, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands., Bond MJG; Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands., Meiqari L; Department of Pathology, Netherlands Cancer Institute, Amsterdam, the Netherlands., Huitink I; Department of Pathology, Netherlands Cancer Institute, Amsterdam, the Netherlands., Giovannetti E; Cancer Center Amsterdam, Amsterdam, the Netherlands., Stoker J; Cancer Center Amsterdam, Amsterdam, the Netherlands; Department of Radiology and Nuclear Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands., Verpalen I; Cancer Center Amsterdam, Amsterdam, the Netherlands; Department of Radiology and Nuclear Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands., van den Broek D; Department of Laboratory Medicine, The Netherlands Cancer Institute, Amsterdam, the Netherlands., Meijer GA; Department of Pathology, Netherlands Cancer Institute, Amsterdam, the Netherlands., Swijnenburg RJ; Department of Surgery, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands; Cancer Center Amsterdam, Amsterdam, the Netherlands., Punt CJA; Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands., Scharpf RB; The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Leal A; Delfi Diagnostics, Inc., Baltimore, MD, USA., Dracopoli NC; Delfi Diagnostics, Inc., Baltimore, MD, USA., Velculescu VE; The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Kok NFM; Department of Surgery, Netherlands Cancer Institute, Amsterdam, the Netherlands., Kazemier G; Department of Surgery, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands; Cancer Center Amsterdam, Amsterdam, the Netherlands. Electronic address: g.kazemier@amsterdamumc.nl., Fijneman RJA; Department of Pathology, Netherlands Cancer Institute, Amsterdam, the Netherlands. Electronic address: r.fijneman@nki.nl.
Source: EBioMedicine [EBioMedicine] 2026 Jan; Vol. 123, pp. 106081. Date of Electronic Publication: 2025 Dec 16.
Publication Type: Clinical Trial, Phase III; Journal Article; Multicenter Study; Randomized Controlled Trial
Journal Info: Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 101647039 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2352-3964 (Electronic) Linking ISSN: 23523964 NLM ISO Abbreviation: EBioMedicine Subsets: MEDLINE
Database: MEDLINE Ultimate
FullText Text:
  Availability: 0
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 41406506
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Combining cell-free DNA fragmentomes and total tumour volume improves prognostication and tumour response evaluation in patients with colorectal cancer liver metastases.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Crnovrsanin+N%22">Crnovrsanin N</searchLink>; Department of Pathology, Netherlands Cancer Institute, Amsterdam, the Netherlands; Department of General, Abdominal and Transplantation Surgery, University Hospital Heidelberg, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Zeeuw+JM%22">Zeeuw JM</searchLink>; Department of Surgery, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands; Cancer Center Amsterdam, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Ali+M%22">Ali M</searchLink>; Department of Surgery, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands; Cancer Center Amsterdam, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Kemna+R%22">Kemna R</searchLink>; Department of Surgery, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands; Cancer Center Amsterdam, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Alipanahi+B%22">Alipanahi B</searchLink>; Delfi Diagnostics, Inc., Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Lumbard+K%22">Lumbard K</searchLink>; Delfi Diagnostics, Inc., Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Skidmore+ZL%22">Skidmore ZL</searchLink>; Delfi Diagnostics, Inc., Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Rinaldi+L%22">Rinaldi L</searchLink>; Delfi Diagnostics, Inc., Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22van+'t+Erve+I%22">van 't Erve I</searchLink>; Department of Pathology, Netherlands Cancer Institute, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Wesdorp+NJ%22">Wesdorp NJ</searchLink>; Department of Surgery, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands; Cancer Center Amsterdam, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Huiskens+J%22">Huiskens J</searchLink>; Department of Surgery, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22van+Steijn+D%22">van Steijn D</searchLink>; Department of Pathology, Netherlands Cancer Institute, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22van+Waesberghe+JH%22">van Waesberghe JH</searchLink>; Cancer Center Amsterdam, Amsterdam, the Netherlands; Department of Radiology and Nuclear Medicine, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22van+den+Bergh+J%22">van den Bergh J</searchLink>; Cancer Center Amsterdam, Amsterdam, the Netherlands; Department of Radiology and Nuclear Medicine, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Nota+I%22">Nota I</searchLink>; Cancer Center Amsterdam, Amsterdam, the Netherlands; Department of Radiology and Nuclear Medicine, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Moos+S%22">Moos S</searchLink>; Cancer Center Amsterdam, Amsterdam, the Netherlands; Department of Radiology and Nuclear Medicine, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Bond+MJG%22">Bond MJG</searchLink>; Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Meiqari+L%22">Meiqari L</searchLink>; Department of Pathology, Netherlands Cancer Institute, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Huitink+I%22">Huitink I</searchLink>; Department of Pathology, Netherlands Cancer Institute, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Giovannetti+E%22">Giovannetti E</searchLink>; Cancer Center Amsterdam, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Stoker+J%22">Stoker J</searchLink>; Cancer Center Amsterdam, Amsterdam, the Netherlands; Department of Radiology and Nuclear Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Verpalen+I%22">Verpalen I</searchLink>; Cancer Center Amsterdam, Amsterdam, the Netherlands; Department of Radiology and Nuclear Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22van+den+Broek+D%22">van den Broek D</searchLink>; Department of Laboratory Medicine, The Netherlands Cancer Institute, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Meijer+GA%22">Meijer GA</searchLink>; Department of Pathology, Netherlands Cancer Institute, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Swijnenburg+RJ%22">Swijnenburg RJ</searchLink>; Department of Surgery, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands; Cancer Center Amsterdam, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Punt+CJA%22">Punt CJA</searchLink>; Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Scharpf+RB%22">Scharpf RB</searchLink>; The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Leal+A%22">Leal A</searchLink>; Delfi Diagnostics, Inc., Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Dracopoli+NC%22">Dracopoli NC</searchLink>; Delfi Diagnostics, Inc., Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Velculescu+VE%22">Velculescu VE</searchLink>; The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Kok+NFM%22">Kok NFM</searchLink>; Department of Surgery, Netherlands Cancer Institute, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Kazemier+G%22">Kazemier G</searchLink>; Department of Surgery, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands; Cancer Center Amsterdam, Amsterdam, the Netherlands. Electronic address: g.kazemier@amsterdamumc.nl.<br /><searchLink fieldCode="AU" term="%22Fijneman+RJA%22">Fijneman RJA</searchLink>; Department of Pathology, Netherlands Cancer Institute, Amsterdam, the Netherlands. Electronic address: r.fijneman@nki.nl.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22101647039%22">EBioMedicine</searchLink> [EBioMedicine] 2026 Jan; Vol. 123, pp. 106081. <i>Date of Electronic Publication: </i>2025 Dec 16.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Clinical Trial, Phase III; Journal Article; Multicenter Study; Randomized Controlled Trial
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+B%2EV%22">Elsevier B.V </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>101647039 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2352-3964 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2223523964%22">23523964 </searchLink><i>NLM ISO Abbreviation: </i>EBioMedicine <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41406506
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1016/j.ebiom.2025.106081
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: 106081
    Titles:
      – TitleFull: Combining cell-free DNA fragmentomes and total tumour volume improves prognostication and tumour response evaluation in patients with colorectal cancer liver metastases.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Crnovrsanin N
      – PersonEntity:
          Name:
            NameFull: Zeeuw JM
      – PersonEntity:
          Name:
            NameFull: Ali M
      – PersonEntity:
          Name:
            NameFull: Kemna R
      – PersonEntity:
          Name:
            NameFull: Alipanahi B
      – PersonEntity:
          Name:
            NameFull: Lumbard K
      – PersonEntity:
          Name:
            NameFull: Skidmore ZL
      – PersonEntity:
          Name:
            NameFull: Rinaldi L
      – PersonEntity:
          Name:
            NameFull: van 't Erve I
      – PersonEntity:
          Name:
            NameFull: Wesdorp NJ
      – PersonEntity:
          Name:
            NameFull: Huiskens J
      – PersonEntity:
          Name:
            NameFull: van Steijn D
      – PersonEntity:
          Name:
            NameFull: van Waesberghe JH
      – PersonEntity:
          Name:
            NameFull: van den Bergh J
      – PersonEntity:
          Name:
            NameFull: Nota I
      – PersonEntity:
          Name:
            NameFull: Moos S
      – PersonEntity:
          Name:
            NameFull: Bond MJG
      – PersonEntity:
          Name:
            NameFull: Meiqari L
      – PersonEntity:
          Name:
            NameFull: Huitink I
      – PersonEntity:
          Name:
            NameFull: Giovannetti E
      – PersonEntity:
          Name:
            NameFull: Stoker J
      – PersonEntity:
          Name:
            NameFull: Verpalen I
      – PersonEntity:
          Name:
            NameFull: van den Broek D
      – PersonEntity:
          Name:
            NameFull: Meijer GA
      – PersonEntity:
          Name:
            NameFull: Swijnenburg RJ
      – PersonEntity:
          Name:
            NameFull: Punt CJA
      – PersonEntity:
          Name:
            NameFull: Scharpf RB
      – PersonEntity:
          Name:
            NameFull: Leal A
      – PersonEntity:
          Name:
            NameFull: Dracopoli NC
      – PersonEntity:
          Name:
            NameFull: Velculescu VE
      – PersonEntity:
          Name:
            NameFull: Kok NFM
      – PersonEntity:
          Name:
            NameFull: Kazemier G
      – PersonEntity:
          Name:
            NameFull: Fijneman RJA
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 01
              Text: 2026 Jan
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 2352-3964
          Numbering:
            – Type: volume
              Value: 123
          Titles:
            – TitleFull: EBioMedicine
              Type: main
ResultId 1