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Protective role of agomelatine via modulation of TLR4/NF-κB: NLRP3/IL-1β signaling pathways in testosterone-induced benign prostatic hyperplasia in rats.

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Title: Protective role of agomelatine via modulation of TLR4/NF-κB: NLRP3/IL-1β signaling pathways in testosterone-induced benign prostatic hyperplasia in rats.
Authors: Abdel-Aziz AM; Department of Medical Pharmacology, Faculty of Medicine, Minia University, Minya, 61519, Egypt. asmaaabdelaziz303@yahoo.com., Ahmed SM; Department of Medical Pharmacology, Faculty of Medicine, Minia University, Minya, 61519, Egypt., Abdelzaher WY; Department of Medical Pharmacology, Faculty of Medicine, Minia University, Minya, 61519, Egypt.; Faculty of Nursing, Lotus University, Minya, 61768, Egypt., Mohamed NA; Department of Histology and Cell Biology, Faculty of Medicine, Minia University, Minya, 61519, Egypt.; Faculty of Nursing, Lotus University, Minya, 61768, Egypt., Abdelkader AE; Department of Medical Microbiology and Immunology, Faculty of Medicine, Minia University, Minya, 61519, Egypt., Ahmed RF; Department of Biochemistry, Faculty of Medicine, Minia University, Minya, 61519, Egypt., Ali AMM; Department of Forensic Medicine & Clinical Toxicology, Faculty of Medicine, Minia University, Minya, 61519, Egypt., Kotb ASM; Department of Physiology, Faculty of Medicine, Minia University, Minya, 61519, Egypt., Abdelmonaem AA; Department of Medical Pharmacology, Faculty of Medicine, Minia University, Minya, 61519, Egypt.
Source: Naunyn-Schmiedeberg's archives of pharmacology [Naunyn Schmiedebergs Arch Pharmacol] 2026 Mar; Vol. 399 (6), pp. 7989-8002. Date of Electronic Publication: 2025 Dec 19.
Publication Type: Journal Article
Journal Info: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0326264 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1912 (Electronic) Linking ISSN: 00281298 NLM ISO Abbreviation: Naunyn Schmiedebergs Arch Pharmacol Subsets: MEDLINE
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  Data: Protective role of agomelatine via modulation of TLR4/NF-κB: NLRP3/IL-1β signaling pathways in testosterone-induced benign prostatic hyperplasia in rats.
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  Data: <searchLink fieldCode="AU" term="%22Abdel-Aziz+AM%22">Abdel-Aziz AM</searchLink>; Department of Medical Pharmacology, Faculty of Medicine, Minia University, Minya, 61519, Egypt. asmaaabdelaziz303@yahoo.com.<br /><searchLink fieldCode="AU" term="%22Ahmed+SM%22">Ahmed SM</searchLink>; Department of Medical Pharmacology, Faculty of Medicine, Minia University, Minya, 61519, Egypt.<br /><searchLink fieldCode="AU" term="%22Abdelzaher+WY%22">Abdelzaher WY</searchLink>; Department of Medical Pharmacology, Faculty of Medicine, Minia University, Minya, 61519, Egypt.; Faculty of Nursing, Lotus University, Minya, 61768, Egypt.<br /><searchLink fieldCode="AU" term="%22Mohamed+NA%22">Mohamed NA</searchLink>; Department of Histology and Cell Biology, Faculty of Medicine, Minia University, Minya, 61519, Egypt.; Faculty of Nursing, Lotus University, Minya, 61768, Egypt.<br /><searchLink fieldCode="AU" term="%22Abdelkader+AE%22">Abdelkader AE</searchLink>; Department of Medical Microbiology and Immunology, Faculty of Medicine, Minia University, Minya, 61519, Egypt.<br /><searchLink fieldCode="AU" term="%22Ahmed+RF%22">Ahmed RF</searchLink>; Department of Biochemistry, Faculty of Medicine, Minia University, Minya, 61519, Egypt.<br /><searchLink fieldCode="AU" term="%22Ali+AMM%22">Ali AMM</searchLink>; Department of Forensic Medicine & Clinical Toxicology, Faculty of Medicine, Minia University, Minya, 61519, Egypt.<br /><searchLink fieldCode="AU" term="%22Kotb+ASM%22">Kotb ASM</searchLink>; Department of Physiology, Faculty of Medicine, Minia University, Minya, 61519, Egypt.<br /><searchLink fieldCode="AU" term="%22Abdelmonaem+AA%22">Abdelmonaem AA</searchLink>; Department of Medical Pharmacology, Faculty of Medicine, Minia University, Minya, 61519, Egypt.
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              Text: 2026 Mar
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