Anti-CRISPR-mediated continuous directed evolution of CRISPR-Cas9 in human cells.
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| Title: | Anti-CRISPR-mediated continuous directed evolution of CRISPR-Cas9 in human cells. |
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| Authors: | Sabol AL; Contributed equally to this work.; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA., Mengiste AA; Contributed equally to this work.; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA., Sreekanth V; Contributed equally to this work.; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA., Singh P; Contributed equally to this work.; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA., Hendel SJ; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA., Tran MTN; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA., Barybin AM; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA., Chaudhary S; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA., Harris RM; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA., Liivak K; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA., Severance ZC; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA., Locicero CM; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA., Kailass K; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA., Lee C; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA., Xu LQ; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA., Butty VL; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.; BioMicro Center, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA., Choudhary A; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.; Divisions of Renal Medicine and Engineering, Brigham and Women's Hospital, Boston, Massachusetts, 02115, USA.; Department of Medicine, Harvard Medical School, Boston, MA, 02115, USA., Shoulders MD; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA. |
| Source: | BioRxiv : the preprint server for biology [bioRxiv] 2025 Dec 11. Date of Electronic Publication: 2025 Dec 11. |
| Publication Type: | Journal Article; Preprint |
| Journal Info: | Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE |
| Database: | MEDLINE Ultimate |
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