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Integrative Multiomics and Drug Sensitivity Profiling Reveal Potential Biomarkers and Therapeutic Strategies in Pediatric Solid Tumors.

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Title: Integrative Multiomics and Drug Sensitivity Profiling Reveal Potential Biomarkers and Therapeutic Strategies in Pediatric Solid Tumors.
Authors: ElHarouni D; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany.; Faculty of Biosciences, Heidelberg University, Heidelberg, Germany., Hernansaiz-Ballesteros R; Faculty of Medicine and Heidelberg University Hospital, Institute of Computational Biomedicine, Heidelberg University, Heidelberg, Germany., Peterziel H; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), and National Center for Tumor Diseases (NCT), Heidelberg, Germany., Balasubramanian GP; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany., Previti C; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany.; Omics IT and Data Management Core Facility (ODCF), German Cancer Research Center (DKFZ), Heidelberg, Germany., Schramm K; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Division of pediatric Glioma Research Group, DKFZ, Heidelberg, Germany., Blattner-Johnson M; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Division of pediatric Glioma Research Group, DKFZ, Heidelberg, Germany., Kabbe R; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany., Jones BC; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Division of pediatric Glioma Research Group, DKFZ, Heidelberg, Germany.; Department of Pediatric Oncology, Hematology and Immunology Heidelberg University Hospital and National Center for Tumor Diseases (NCT), Heidelberg, Germany., Oppermann S; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), and National Center for Tumor Diseases (NCT), Heidelberg, Germany.; Institute for Pharmacology and Clinical Pharmacy, Goethe University Frankfurt, Frankfurt, Germany., Jones DTW; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Division of pediatric Glioma Research Group, DKFZ, Heidelberg, Germany.; National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany., Pfister SM; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany.; Department of Pediatric Oncology, Hematology and Immunology Heidelberg University Hospital and National Center for Tumor Diseases (NCT), Heidelberg, Germany., Witt O; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), and National Center for Tumor Diseases (NCT), Heidelberg, Germany.; Department of Pediatric Oncology, Hematology and Immunology Heidelberg University Hospital and National Center for Tumor Diseases (NCT), Heidelberg, Germany., Saez-Rodriguez J; Faculty of Medicine and Heidelberg University Hospital, Institute of Computational Biomedicine, Heidelberg University, Heidelberg, Germany., Oehme I; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), and National Center for Tumor Diseases (NCT), Heidelberg, Germany., Jäger N; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany., Schlesner M; Biomedical Informatics, Data Mining and Data Analytics, Faculty of Applied Computer Science and Medical Faculty, University of Augsburg, Augsburg, Germany.
Source: Cancer research [Cancer Res] 2026 Feb 02; Vol. 86 (3), pp. 773-784.
Publication Type: Journal Article
Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 2984705R Publication Model: Print Cited Medium: Internet ISSN: 1538-7445 (Electronic) Linking ISSN: 00085472 NLM ISO Abbreviation: Cancer Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22ElHarouni+D%22">ElHarouni D</searchLink>; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany.; Faculty of Biosciences, Heidelberg University, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Hernansaiz-Ballesteros+R%22">Hernansaiz-Ballesteros R</searchLink>; Faculty of Medicine and Heidelberg University Hospital, Institute of Computational Biomedicine, Heidelberg University, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Peterziel+H%22">Peterziel H</searchLink>; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), and National Center for Tumor Diseases (NCT), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Balasubramanian+GP%22">Balasubramanian GP</searchLink>; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Previti+C%22">Previti C</searchLink>; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany.; Omics IT and Data Management Core Facility (ODCF), German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Schramm+K%22">Schramm K</searchLink>; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Division of pediatric Glioma Research Group, DKFZ, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Blattner-Johnson+M%22">Blattner-Johnson M</searchLink>; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Division of pediatric Glioma Research Group, DKFZ, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Kabbe+R%22">Kabbe R</searchLink>; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Jones+BC%22">Jones BC</searchLink>; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Division of pediatric Glioma Research Group, DKFZ, Heidelberg, Germany.; Department of Pediatric Oncology, Hematology and Immunology Heidelberg University Hospital and National Center for Tumor Diseases (NCT), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Oppermann+S%22">Oppermann S</searchLink>; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), and National Center for Tumor Diseases (NCT), Heidelberg, Germany.; Institute for Pharmacology and Clinical Pharmacy, Goethe University Frankfurt, Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Jones+DTW%22">Jones DTW</searchLink>; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Division of pediatric Glioma Research Group, DKFZ, Heidelberg, Germany.; National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Pfister+SM%22">Pfister SM</searchLink>; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany.; Department of Pediatric Oncology, Hematology and Immunology Heidelberg University Hospital and National Center for Tumor Diseases (NCT), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Witt+O%22">Witt O</searchLink>; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), and National Center for Tumor Diseases (NCT), Heidelberg, Germany.; Department of Pediatric Oncology, Hematology and Immunology Heidelberg University Hospital and National Center for Tumor Diseases (NCT), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Saez-Rodriguez+J%22">Saez-Rodriguez J</searchLink>; Faculty of Medicine and Heidelberg University Hospital, Institute of Computational Biomedicine, Heidelberg University, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Oehme+I%22">Oehme I</searchLink>; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), and National Center for Tumor Diseases (NCT), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Jäger+N%22">Jäger N</searchLink>; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Schlesner+M%22">Schlesner M</searchLink>; Biomedical Informatics, Data Mining and Data Analytics, Faculty of Applied Computer Science and Medical Faculty, University of Augsburg, Augsburg, Germany.
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