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Deciphering the significance of tumor necrosis and developing a grading system in combined hepatocellular-cholangiocarcinoma: A multicenter pathological study.

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Title: Deciphering the significance of tumor necrosis and developing a grading system in combined hepatocellular-cholangiocarcinoma: A multicenter pathological study.
Authors: Wang H; Department of Pathology, Eastern Hepatobiliary Surgery Hospital, Naval Medical University, Yangpu, Shanghai 200438, China; Department of Pathology, Changhai Hospital, Naval Medical University, Yangpu, Shanghai 200433, China., Qian YW; Department of Pathology, Eastern Hepatobiliary Surgery Hospital, Naval Medical University, Yangpu, Shanghai 200438, China., Sheng X; Department of Pathology, Minhang Hospital, Fudan University, Minhang, Shanghai 201199, China., Xia CY; Department of Pathology, Changzheng Hospital, Naval Medical University, Huangpu, Shanghai 200003, China., Chen HZ; Department of Pathology, Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, Gongshu, Hangzhou 310000, China., Cao ZY; Department of Pathology, Eastern Hepatobiliary Surgery Hospital, Naval Medical University, Yangpu, Shanghai 200438, China., Yu H; Department of Pathology, Eastern Hepatobiliary Surgery Hospital, Naval Medical University, Yangpu, Shanghai 200438, China., Zhou YY; Department of Pathology, Eastern Hepatobiliary Surgery Hospital, Naval Medical University, Yangpu, Shanghai 200438, China., Cong WM; Department of Pathology, Eastern Hepatobiliary Surgery Hospital, Naval Medical University, Yangpu, Shanghai 200438, China. Electronic address: wmcong@smmu.edu.cn., He MX; Department of Pathology, Changhai Hospital, Naval Medical University, Yangpu, Shanghai 200433, China. Electronic address: hmm26@163.com., Dong H; Department of Pathology, Eastern Hepatobiliary Surgery Hospital, Naval Medical University, Yangpu, Shanghai 200438, China. Electronic address: huidongwh@126.com.
Source: Pathology, research and practice [Pathol Res Pract] 2026 Feb; Vol. 278, pp. 156335. Date of Electronic Publication: 2025 Dec 16.
Publication Type: Journal Article; Multicenter Study
Journal Info: Publisher: Gustav Fischer Verlag Country of Publication: Germany NLM ID: 7806109 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1618-0631 (Electronic) Linking ISSN: 03440338 NLM ISO Abbreviation: Pathol Res Pract Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: Deciphering the significance of tumor necrosis and developing a grading system in combined hepatocellular-cholangiocarcinoma: A multicenter pathological study.
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  Data: <searchLink fieldCode="AU" term="%22Wang+H%22">Wang H</searchLink>; Department of Pathology, Eastern Hepatobiliary Surgery Hospital, Naval Medical University, Yangpu, Shanghai 200438, China; Department of Pathology, Changhai Hospital, Naval Medical University, Yangpu, Shanghai 200433, China.<br /><searchLink fieldCode="AU" term="%22Qian+YW%22">Qian YW</searchLink>; Department of Pathology, Eastern Hepatobiliary Surgery Hospital, Naval Medical University, Yangpu, Shanghai 200438, China.<br /><searchLink fieldCode="AU" term="%22Sheng+X%22">Sheng X</searchLink>; Department of Pathology, Minhang Hospital, Fudan University, Minhang, Shanghai 201199, China.<br /><searchLink fieldCode="AU" term="%22Xia+CY%22">Xia CY</searchLink>; Department of Pathology, Changzheng Hospital, Naval Medical University, Huangpu, Shanghai 200003, China.<br /><searchLink fieldCode="AU" term="%22Chen+HZ%22">Chen HZ</searchLink>; Department of Pathology, Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, Gongshu, Hangzhou 310000, China.<br /><searchLink fieldCode="AU" term="%22Cao+ZY%22">Cao ZY</searchLink>; Department of Pathology, Eastern Hepatobiliary Surgery Hospital, Naval Medical University, Yangpu, Shanghai 200438, China.<br /><searchLink fieldCode="AU" term="%22Yu+H%22">Yu H</searchLink>; Department of Pathology, Eastern Hepatobiliary Surgery Hospital, Naval Medical University, Yangpu, Shanghai 200438, China.<br /><searchLink fieldCode="AU" term="%22Zhou+YY%22">Zhou YY</searchLink>; Department of Pathology, Eastern Hepatobiliary Surgery Hospital, Naval Medical University, Yangpu, Shanghai 200438, China.<br /><searchLink fieldCode="AU" term="%22Cong+WM%22">Cong WM</searchLink>; Department of Pathology, Eastern Hepatobiliary Surgery Hospital, Naval Medical University, Yangpu, Shanghai 200438, China. Electronic address: wmcong@smmu.edu.cn.<br /><searchLink fieldCode="AU" term="%22He+MX%22">He MX</searchLink>; Department of Pathology, Changhai Hospital, Naval Medical University, Yangpu, Shanghai 200433, China. Electronic address: hmm26@163.com.<br /><searchLink fieldCode="AU" term="%22Dong+H%22">Dong H</searchLink>; Department of Pathology, Eastern Hepatobiliary Surgery Hospital, Naval Medical University, Yangpu, Shanghai 200438, China. Electronic address: huidongwh@126.com.
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  Data: <searchLink fieldCode="JN" term="%227806109%22">Pathology, research and practice</searchLink> [Pathol Res Pract] 2026 Feb; Vol. 278, pp. 156335. <i>Date of Electronic Publication: </i>2025 Dec 16.
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  Data: Journal Article; Multicenter Study
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Gustav+Fischer+Verlag%22">Gustav Fischer Verlag </searchLink><i>Country of Publication: </i>Germany <i>NLM ID: </i>7806109 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1618-0631 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2203440338%22">03440338 </searchLink><i>NLM ISO Abbreviation: </i>Pathol Res Pract <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.prp.2025.156335
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        Text: English
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        StartPage: 156335
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      – TitleFull: Deciphering the significance of tumor necrosis and developing a grading system in combined hepatocellular-cholangiocarcinoma: A multicenter pathological study.
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              Text: 2026 Feb
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