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RAS/PI3K pathway mutations sensitise epithelial ovarian cancer cells to a PARP/NAMPT inhibitor combination.

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Title: RAS/PI3K pathway mutations sensitise epithelial ovarian cancer cells to a PARP/NAMPT inhibitor combination.
Authors: Gruet M; Department of Surgery and Cancer, Imperial College London, London, UK.; Department of Chemistry, Molecular Sciences Research Hub, Imperial College London, London, UK., Xu Y; Department of Surgery and Cancer, Imperial College London, London, UK., An L; Department of Surgery and Cancer, Imperial College London, London, UK., Ma Y; Department of Surgery and Cancer, Imperial College London, London, UK., Balcells C; Department of Surgery and Cancer, Imperial College London, London, UK., Tyson K; Department of Surgery and Cancer, Imperial College London, London, UK., Evangelista LC; Department of Surgery and Cancer, Imperial College London, London, UK., Spear S; Department of Surgery and Cancer, Imperial College London, London, UK., Xu Y; Department of Surgery and Cancer, Imperial College London, London, UK.; Wisdom Lake Academy of Pharmacy, Xi'an Jiaotong-Liverpool University, Suzhou, China., McKinney F; Department of Surgery and Cancer, Imperial College London, London, UK., Babuta J; Department of Metabolism, Digestion and Reproduction, Burlington Danes, Imperial College London, London, UK., Bray C; Department of Surgery and Cancer, Imperial College London, London, UK., Wickremesinghe C; Department of Surgery and Cancer, Imperial College London, London, UK., Siskos AP; Department of Surgery and Cancer, Imperial College London, London, UK., Nijhuis AM; Department of Surgery and Cancer, Imperial College London, London, UK., Tate EW; Department of Chemistry, Molecular Sciences Research Hub, Imperial College London, London, UK., McNeish IA; Department of Surgery and Cancer, Imperial College London, London, UK., Benito A; Department of Surgery and Cancer, Imperial College London, London, UK. a.benito-mauricio@imperial.ac.uk., Keun HC; Department of Surgery and Cancer, Imperial College London, London, UK. h.keun@imperial.ac.uk.
Source: Communications biology [Commun Biol] 2025 Dec 19; Vol. 9 (1), pp. 6. Date of Electronic Publication: 2025 Dec 19.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 101719179 Publication Model: Electronic Cited Medium: Internet ISSN: 2399-3642 (Electronic) Linking ISSN: 23993642 NLM ISO Abbreviation: Commun Biol Subsets: MEDLINE
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