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Genomic and transcriptomic analyses of aortic stenosis enhance therapeutic target discovery and disease prediction.

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Title: Genomic and transcriptomic analyses of aortic stenosis enhance therapeutic target discovery and disease prediction.
Authors: Small AM; Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Program in Medical and Population Genetics and the Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Division of Cardiology, Department of Medicine, VA Boston Healthcare System, Boston, MA, USA., Yang TY; McGill University Health Centre and Research Institute, Montréal, Quebec, Canada.; McGill University, Montréal, Quebec, Canada.; Kyoto-McGill International Collaborative School in Genomic Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan., Itoh S; Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Center for Interdisciplinary Cardiovascular Sciences, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Thériault S; Institut Universitaire de Cardiologie et de Pneumologie de Québec-Université Laval, Quebec City, Quebec, Canada.; Department of Molecular Biology, Medical Biochemistry and Pathology, Université Laval, Quebec City, Quebec, Canada., Dufresne L; McGill University Health Centre and Research Institute, Montréal, Quebec, Canada., Kurosawa R; Laboratory for Cardiovascular Genomics and Informatics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan., Komuro I; International University of Health and Welfare, Tokyo, Japan.; Department of Frontier Cardiovascular Science, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan., Matsuda K; Institute of Medical Science, Laboratory of Genome Technology, Human Genome Center, The University of Tokyo, Tokyo, Japan., Vy HMT; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Farber-Eger EH; Department of Medicine, Division of Cardiology, Vanderbilt University Medical Center, Nashville, TN, USA., Shaffer LL; Department of Medicine, Division of Cardiology, Vanderbilt University Medical Center, Nashville, TN, USA., Boulier KM; Division of Cardiology, Department of Medicine, Ronald Reagan UCLA Medical Center, Los Angeles, CA, USA., Corey KM; Duke Molecular Physiology Institute, Duke University, Durham, NC, USA.; Department of Medicine, Duke University, Durham, NC, USA., Ramaker ME; Duke Molecular Physiology Institute, Duke University, Durham, NC, USA., Laporte F; Nantes Université, CHU Nantes, CNRS, INSERM, l'institut du Thorax, Nantes, France., Schott JJ; Nantes Université, CHU Nantes, CNRS, INSERM, l'institut du Thorax, Nantes, France., Le Scouarnec S; Nantes Université, CHU Nantes, CNRS, INSERM, l'institut du Thorax, Nantes, France., Singh SA; Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Center for Interdisciplinary Cardiovascular Sciences, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Sonawane AR; Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Center for Interdisciplinary Cardiovascular Sciences, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Smith HA; Colorado Center for Personalized Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Rafaels N; Colorado Center for Personalized Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Ghouse J; Department of Cardiology, The Heart Centre, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark., Raja AA; Department of Cardiology, The Heart Centre, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark., Ostrowski SR; Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Sørensen E; Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark., Mikkelsen C; Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark., Pedersen OB; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Clinical Immunology, Zealand University Hospital, Køge, Denmark., Erikstrup C; Department of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark., Ullum H; Statens Serum Institut, Copenhagen, Denmark., Sveinbjornsson G; deCODE genetics/Amgen, Inc., Reykjavik, Iceland., Gudbjartsson DF; deCODE genetics/Amgen, Inc., Reykjavik, Iceland., Abner E; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia., Lee J; Program in Medical and Population Genetics and the Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Harvard-MIT Health Sciences and Technology Program, Harvard Medical School, Boston, MA, USA.; Cardiovascular Research Center and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA., Ganna A; Institute for Molecular Medicine Finland, HiLIFE, University of Helsinki, Helsinki, Finland.; Analytic and Translational Genetics Unit, Boston, MA, USA., Nowak-Göttl U; Thrombosis and Hemostasis Unit, Institute of Clinical Chemistry, University Hospital Kiel, Kiel, Germany., Finer S; Wolfson Institute of Population Health, Queen Mary University of London, London, UK., Schumacher J; Institute of Human Genetics, Philipps University of Marburg, Marburg, Germany.; Institute of Human Genetics, University of Bonn and University Hospital Bonn, Bonn, Germany., Maj C; Institute of Human Genetics, Philipps University of Marburg, Marburg, Germany., Al-Kassou B; Department of Medicine II, Heart Center Bonn, University of Bonn and University Hospital Bonn, Bonn, Germany., Nickenig G; Department of Medicine II, Heart Center Bonn, University of Bonn and University Hospital Bonn, Bonn, Germany., Trenkwalder T; Department of Cardiology, German Heart Centre Munich, TUM University Hospital, School of Medicine and Health, Technical University of Munich, Munich, Germany.; DZHK (German Center for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany., Dreβen M; Department of Cardiovascular Surgery, Institute Insure, German Heart Center Munich, School of Medicine & Health, TUM University Hospital, Technical University of Munich, Munich, Germany., Krane M; DZHK (German Center for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany.; Department of Cardiovascular Surgery, Institute Insure, German Heart Center Munich, School of Medicine & Health, TUM University Hospital, Technical University of Munich, Munich, Germany.; Department of Surgery, Yale University School of Medicine, New Haven, CT, USA., Nöthen MM; Institute of Human Genetics, University of Bonn and University Hospital Bonn, Bonn, Germany., Moksnes MR; HUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, NTNU Norwegian University of Science and Technology, Trondheim, Norway., Brumpton BM; HUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, NTNU Norwegian University of Science and Technology, Trondheim, Norway.; Clinic of Medicine, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway., Knight S; Intermountain Healthcare, Salt Lake City, UT, USA., Knowlton KU; Intermountain Healthcare, Salt Lake City, UT, USA., Nadauld L; Intermountain Healthcare, Salt Lake City, UT, USA., Debiec R; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.; NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK., Musameh MD; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.; NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK., Braund PS; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.; NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK., Nelson CP; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.; NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK., Czuba T; The Wallenberg Laboratory/Department of Molecular and Clinical Medicine, Institute of Medicine and Science for Life Laboratory, Gothenburg University and Department of Cardiology, Sahlgrenska University Hospital, Gothenburg, Sweden., Melander O; Department of Internal Medicine, Clinical Sciences, Lund University and Skåne University Hospital, Malmö, Sweden., Selvaraj MS; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA., Koyama S; Program in Medical and Population Genetics and the Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Bhukar R; Program in Medical and Population Genetics and the Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Ruan Y; Program in Medical and Population Genetics and the Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Ljungberg J; Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden., Damrauer SM; Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Corporal Michael Crescenz, VA Medical Center, Philadelphia, PA, USA., Levin MG; Division of Cardiovascular Medicine, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Franke A; Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany., Berger K; Institute of Epidemiology and Social Medicine, University of Münster, Munster, Germany., Ruff CT; TIMI Study Group, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Melloni GEM; TIMI Study Group, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Kamanu FK; TIMI Study Group, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Ito K; Laboratory for Cardiovascular Genomics and Informatics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.; Department of Advanced Biomedical Data Science, Graduate School of Medicine, Chiba University, Chiba, Japan., Do R; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Loos RJF; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Science, University of Copenhagen, Copenhagen, Denmark., Schunkert H; Department of Cardiology, German Heart Centre Munich, TUM University Hospital, School of Medicine and Health, Technical University of Munich, Munich, Germany.; DZHK (German Center for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany., Wells QS; Department of Medicine, Division of Cardiology, Vanderbilt University Medical Center, Nashville, TN, USA., Shah SH; Duke Molecular Physiology Institute, Duke University, Durham, NC, USA.; Department of Medicine, Division of Cardiology, Duke University, Durham, NC, USA.; Duke Clinical Research Institute, Duke University, Durham, NC, USA., Le Tourneau T; Nantes Université, CHU Nantes, CNRS, INSERM, l'institut du Thorax, Nantes, France., Messika-Zeitoun D; Division of Cardiology, University of Ottawa Heart Institute, Ottawa, Ontario, Canada., Gignoux C; Colorado Center for Personalized Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Bundgaard H; Department of Cardiology, The Heart Centre, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark., Larsson SC; Medical Epidemiology, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.; Unit of Cardiovascular and Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden., Michaëlsson K; Medical Epidemiology, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden., Holm H; deCODE genetics/Amgen, Inc., Reykjavik, Iceland., Helgadottir A; deCODE genetics/Amgen, Inc., Reykjavik, Iceland., Esko T; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia., van Heel DA; Blizard Institute, Queen Mary University of London, London, UK., Mathieu P; Institut Universitaire de Cardiologie et de Pneumologie de Québec-Université Laval, Quebec City, Quebec, Canada.; Department of Surgery, Université Laval, Quebec City, Quebec, Canada., Samani NJ; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.; NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK., Smith JG; The Wallenberg Laboratory/Department of Molecular and Clinical Medicine, Institute of Medicine and Science for Life Laboratory, Gothenburg University and Department of Cardiology, Sahlgrenska University Hospital, Gothenburg, Sweden.; Department of Cardiology, Clinical Sciences, Lund University and Skåne University Hospital, Lund, Sweden.; Wallenberg Center for Molecular Medicine and Lund University Diabetes Center, Lund University, Lund, Sweden., Söderberg S; Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden., Rader DJ; Division of Cardiovascular Medicine, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Marston NA; TIMI Study Group, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Sabatine MS; TIMI Study Group, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Pasaniuc B; Interdepartmental Program in Bioinformatics, University of California, Los Angeles, CA, USA., Cho K; Department of Medicine, Harvard Medical School, Boston, MA, USA.; MVP Boston Coordinating Center, VA Boston Healthcare System, Boston, MA, USA.; Department of Medicine, Division of Aging, Brigham and Women's Hospital, Boston, MA, USA., Wilson PWF; Atlanta VA Medical Center, Atlanta, GA, USA., O'Donnell CJ; Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Division of Cardiology, Department of Medicine, VA Boston Healthcare System, Boston, MA, USA., Stefansson K; deCODE genetics/Amgen, Inc., Reykjavik, Iceland., Bossé Y; Institut Universitaire de Cardiologie et de Pneumologie de Québec-Université Laval, Quebec City, Quebec, Canada.; Department of Molecular Medicine, Université Laval, Quebec City, Quebec, Canada., Aikawa E; Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Center for Interdisciplinary Cardiovascular Sciences, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Engert JC; McGill University Health Centre and Research Institute, Montréal, Quebec, Canada.; McGill University, Montréal, Quebec, Canada., Peloso GM; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Natarajan P; Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. pnatarajan@mgh.harvard.edu.; Broad Institute of MIT and Harvard, Cambridge, MA, USA. pnatarajan@mgh.harvard.edu.; Center for Genomic Medicine, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA. pnatarajan@mgh.harvard.edu., Thanassoulis G; McGill University Health Centre and Research Institute, Montréal, Quebec, Canada. g.thanassoulis@gmail.com.; McGill University, Montréal, Quebec, Canada. g.thanassoulis@gmail.com.
Corporate Authors: Colorado Center for Personalized Medicine, DBDS Genomic Consortium, Estonian Biobank Research Team, Genes & Health Research Team
Source: Nature genetics [Nat Genet] 2026 Jan; Vol. 58 (1), pp. 57-66. Date of Electronic Publication: 2025 Dec 19.
Publication Type: Journal Article; Meta-Analysis
Journal Info: Publisher: Nature Pub. Co Country of Publication: United States NLM ID: 9216904 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1718 (Electronic) Linking ISSN: 10614036 NLM ISO Abbreviation: Nat Genet Subsets: MEDLINE
Database: MEDLINE Ultimate
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DbLabel: MEDLINE Ultimate
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  Label: Title
  Group: Ti
  Data: Genomic and transcriptomic analyses of aortic stenosis enhance therapeutic target discovery and disease prediction.
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  Label: Authors
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  Data: <searchLink fieldCode="AU" term="%22Small+AM%22">Small AM</searchLink>; Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Program in Medical and Population Genetics and the Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Division of Cardiology, Department of Medicine, VA Boston Healthcare System, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Yang+TY%22">Yang TY</searchLink>; McGill University Health Centre and Research Institute, Montréal, Quebec, Canada.; McGill University, Montréal, Quebec, Canada.; Kyoto-McGill International Collaborative School in Genomic Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Itoh+S%22">Itoh S</searchLink>; Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Center for Interdisciplinary Cardiovascular Sciences, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Thériault+S%22">Thériault S</searchLink>; Institut Universitaire de Cardiologie et de Pneumologie de Québec-Université Laval, Quebec City, Quebec, Canada.; Department of Molecular Biology, Medical Biochemistry and Pathology, Université Laval, Quebec City, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Dufresne+L%22">Dufresne L</searchLink>; McGill University Health Centre and Research Institute, Montréal, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Kurosawa+R%22">Kurosawa R</searchLink>; Laboratory for Cardiovascular Genomics and Informatics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.<br /><searchLink fieldCode="AU" term="%22Komuro+I%22">Komuro I</searchLink>; International University of Health and Welfare, Tokyo, Japan.; Department of Frontier Cardiovascular Science, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Matsuda+K%22">Matsuda K</searchLink>; Institute of Medical Science, Laboratory of Genome Technology, Human Genome Center, The University of Tokyo, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Vy+HMT%22">Vy HMT</searchLink>; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Farber-Eger+EH%22">Farber-Eger EH</searchLink>; Department of Medicine, Division of Cardiology, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Shaffer+LL%22">Shaffer LL</searchLink>; Department of Medicine, Division of Cardiology, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Boulier+KM%22">Boulier KM</searchLink>; Division of Cardiology, Department of Medicine, Ronald Reagan UCLA Medical Center, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Corey+KM%22">Corey KM</searchLink>; Duke Molecular Physiology Institute, Duke University, Durham, NC, USA.; Department of Medicine, Duke University, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Ramaker+ME%22">Ramaker ME</searchLink>; Duke Molecular Physiology Institute, Duke University, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Laporte+F%22">Laporte F</searchLink>; Nantes Université, CHU Nantes, CNRS, INSERM, l'institut du Thorax, Nantes, France.<br /><searchLink fieldCode="AU" term="%22Schott+JJ%22">Schott JJ</searchLink>; Nantes Université, CHU Nantes, CNRS, INSERM, l'institut du Thorax, Nantes, France.<br /><searchLink fieldCode="AU" term="%22Le+Scouarnec+S%22">Le Scouarnec S</searchLink>; Nantes Université, CHU Nantes, CNRS, INSERM, l'institut du Thorax, Nantes, France.<br /><searchLink fieldCode="AU" term="%22Singh+SA%22">Singh SA</searchLink>; Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Center for Interdisciplinary Cardiovascular Sciences, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Sonawane+AR%22">Sonawane AR</searchLink>; Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Center for Interdisciplinary Cardiovascular Sciences, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Smith+HA%22">Smith HA</searchLink>; Colorado Center for Personalized Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.<br /><searchLink fieldCode="AU" term="%22Rafaels+N%22">Rafaels N</searchLink>; Colorado Center for Personalized Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.<br /><searchLink fieldCode="AU" term="%22Ghouse+J%22">Ghouse J</searchLink>; Department of Cardiology, The Heart Centre, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Raja+AA%22">Raja AA</searchLink>; Department of Cardiology, The Heart Centre, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Ostrowski+SR%22">Ostrowski SR</searchLink>; Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Sørensen+E%22">Sørensen E</searchLink>; Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Mikkelsen+C%22">Mikkelsen C</searchLink>; Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Pedersen+OB%22">Pedersen OB</searchLink>; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Clinical Immunology, Zealand University Hospital, Køge, Denmark.<br /><searchLink fieldCode="AU" term="%22Erikstrup+C%22">Erikstrup C</searchLink>; Department of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Ullum+H%22">Ullum H</searchLink>; Statens Serum Institut, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Sveinbjornsson+G%22">Sveinbjornsson G</searchLink>; deCODE genetics/Amgen, Inc., Reykjavik, Iceland.<br /><searchLink fieldCode="AU" term="%22Gudbjartsson+DF%22">Gudbjartsson DF</searchLink>; deCODE genetics/Amgen, Inc., Reykjavik, Iceland.<br /><searchLink fieldCode="AU" term="%22Abner+E%22">Abner E</searchLink>; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.<br /><searchLink fieldCode="AU" term="%22Lee+J%22">Lee J</searchLink>; Program in Medical and Population Genetics and the Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Harvard-MIT Health Sciences and Technology Program, Harvard Medical School, Boston, MA, USA.; Cardiovascular Research Center and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Ganna+A%22">Ganna A</searchLink>; Institute for Molecular Medicine Finland, HiLIFE, University of Helsinki, Helsinki, Finland.; Analytic and Translational Genetics Unit, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Nowak-Göttl+U%22">Nowak-Göttl U</searchLink>; Thrombosis and Hemostasis Unit, Institute of Clinical Chemistry, University Hospital Kiel, Kiel, Germany.<br /><searchLink fieldCode="AU" term="%22Finer+S%22">Finer S</searchLink>; Wolfson Institute of Population Health, Queen Mary University of London, London, UK.<br /><searchLink fieldCode="AU" term="%22Schumacher+J%22">Schumacher J</searchLink>; Institute of Human Genetics, Philipps University of Marburg, Marburg, Germany.; Institute of Human Genetics, University of Bonn and University Hospital Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Maj+C%22">Maj C</searchLink>; Institute of Human Genetics, Philipps University of Marburg, Marburg, Germany.<br /><searchLink fieldCode="AU" term="%22Al-Kassou+B%22">Al-Kassou B</searchLink>; Department of Medicine II, Heart Center Bonn, University of Bonn and University Hospital Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Nickenig+G%22">Nickenig G</searchLink>; Department of Medicine II, Heart Center Bonn, University of Bonn and University Hospital Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Trenkwalder+T%22">Trenkwalder T</searchLink>; Department of Cardiology, German Heart Centre Munich, TUM University Hospital, School of Medicine and Health, Technical University of Munich, Munich, Germany.; DZHK (German Center for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Dreβen+M%22">Dreβen M</searchLink>; Department of Cardiovascular Surgery, Institute Insure, German Heart Center Munich, School of Medicine & Health, TUM University Hospital, Technical University of Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Krane+M%22">Krane M</searchLink>; DZHK (German Center for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany.; Department of Cardiovascular Surgery, Institute Insure, German Heart Center Munich, School of Medicine & Health, TUM University Hospital, Technical University of Munich, Munich, Germany.; Department of Surgery, Yale University School of Medicine, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Nöthen+MM%22">Nöthen MM</searchLink>; Institute of Human Genetics, University of Bonn and University Hospital Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Moksnes+MR%22">Moksnes MR</searchLink>; HUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, NTNU Norwegian University of Science and Technology, Trondheim, Norway.<br /><searchLink fieldCode="AU" term="%22Brumpton+BM%22">Brumpton BM</searchLink>; HUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, NTNU Norwegian University of Science and Technology, Trondheim, Norway.; Clinic of Medicine, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.<br /><searchLink fieldCode="AU" term="%22Knight+S%22">Knight S</searchLink>; Intermountain Healthcare, Salt Lake City, UT, USA.<br /><searchLink fieldCode="AU" term="%22Knowlton+KU%22">Knowlton KU</searchLink>; Intermountain Healthcare, Salt Lake City, UT, USA.<br /><searchLink fieldCode="AU" term="%22Nadauld+L%22">Nadauld L</searchLink>; Intermountain Healthcare, Salt Lake City, UT, USA.<br /><searchLink fieldCode="AU" term="%22Debiec+R%22">Debiec R</searchLink>; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.; NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK.<br /><searchLink fieldCode="AU" term="%22Musameh+MD%22">Musameh MD</searchLink>; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.; NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK.<br /><searchLink fieldCode="AU" term="%22Braund+PS%22">Braund PS</searchLink>; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.; NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK.<br /><searchLink fieldCode="AU" term="%22Nelson+CP%22">Nelson CP</searchLink>; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.; NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK.<br /><searchLink fieldCode="AU" term="%22Czuba+T%22">Czuba T</searchLink>; The Wallenberg Laboratory/Department of Molecular and Clinical Medicine, Institute of Medicine and Science for Life Laboratory, Gothenburg University and Department of Cardiology, Sahlgrenska University Hospital, Gothenburg, Sweden.<br /><searchLink fieldCode="AU" term="%22Melander+O%22">Melander O</searchLink>; Department of Internal Medicine, Clinical Sciences, Lund University and Skåne University Hospital, Malmö, Sweden.<br /><searchLink fieldCode="AU" term="%22Selvaraj+MS%22">Selvaraj MS</searchLink>; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Koyama+S%22">Koyama S</searchLink>; Program in Medical and Population Genetics and the Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Bhukar+R%22">Bhukar R</searchLink>; Program in Medical and Population Genetics and the Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Ruan+Y%22">Ruan Y</searchLink>; Program in Medical and Population Genetics and the Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Ljungberg+J%22">Ljungberg J</searchLink>; Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.<br /><searchLink fieldCode="AU" term="%22Damrauer+SM%22">Damrauer SM</searchLink>; Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Corporal Michael Crescenz, VA Medical Center, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Levin+MG%22">Levin MG</searchLink>; Division of Cardiovascular Medicine, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Franke+A%22">Franke A</searchLink>; Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany.<br /><searchLink fieldCode="AU" term="%22Berger+K%22">Berger K</searchLink>; Institute of Epidemiology and Social Medicine, University of Münster, Munster, Germany.<br /><searchLink fieldCode="AU" term="%22Ruff+CT%22">Ruff CT</searchLink>; TIMI Study Group, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Melloni+GEM%22">Melloni GEM</searchLink>; TIMI Study Group, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Kamanu+FK%22">Kamanu FK</searchLink>; TIMI Study Group, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Ito+K%22">Ito K</searchLink>; Laboratory for Cardiovascular Genomics and Informatics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.; Department of Advanced Biomedical Data Science, Graduate School of Medicine, Chiba University, Chiba, Japan.<br /><searchLink fieldCode="AU" term="%22Do+R%22">Do R</searchLink>; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Loos+RJF%22">Loos RJF</searchLink>; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Science, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Schunkert+H%22">Schunkert H</searchLink>; Department of Cardiology, German Heart Centre Munich, TUM University Hospital, School of Medicine and Health, Technical University of Munich, Munich, Germany.; DZHK (German Center for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Wells+QS%22">Wells QS</searchLink>; Department of Medicine, Division of Cardiology, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Shah+SH%22">Shah SH</searchLink>; Duke Molecular Physiology Institute, Duke University, Durham, NC, USA.; Department of Medicine, Division of Cardiology, Duke University, Durham, NC, USA.; Duke Clinical Research Institute, Duke University, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Le+Tourneau+T%22">Le Tourneau T</searchLink>; Nantes Université, CHU Nantes, CNRS, INSERM, l'institut du Thorax, Nantes, France.<br /><searchLink fieldCode="AU" term="%22Messika-Zeitoun+D%22">Messika-Zeitoun D</searchLink>; Division of Cardiology, University of Ottawa Heart Institute, Ottawa, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Gignoux+C%22">Gignoux C</searchLink>; Colorado Center for Personalized Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.<br /><searchLink fieldCode="AU" term="%22Bundgaard+H%22">Bundgaard H</searchLink>; Department of Cardiology, The Heart Centre, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Larsson+SC%22">Larsson SC</searchLink>; Medical Epidemiology, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.; Unit of Cardiovascular and Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Michaëlsson+K%22">Michaëlsson K</searchLink>; Medical Epidemiology, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.<br /><searchLink fieldCode="AU" term="%22Holm+H%22">Holm H</searchLink>; deCODE genetics/Amgen, Inc., Reykjavik, Iceland.<br /><searchLink fieldCode="AU" term="%22Helgadottir+A%22">Helgadottir A</searchLink>; deCODE genetics/Amgen, Inc., Reykjavik, Iceland.<br /><searchLink fieldCode="AU" term="%22Esko+T%22">Esko T</searchLink>; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.<br /><searchLink fieldCode="AU" term="%22van+Heel+DA%22">van Heel DA</searchLink>; Blizard Institute, Queen Mary University of London, London, UK.<br /><searchLink fieldCode="AU" term="%22Mathieu+P%22">Mathieu P</searchLink>; Institut Universitaire de Cardiologie et de Pneumologie de Québec-Université Laval, Quebec City, Quebec, Canada.; Department of Surgery, Université Laval, Quebec City, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Samani+NJ%22">Samani NJ</searchLink>; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.; NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK.<br /><searchLink fieldCode="AU" term="%22Smith+JG%22">Smith JG</searchLink>; The Wallenberg Laboratory/Department of Molecular and Clinical Medicine, Institute of Medicine and Science for Life Laboratory, Gothenburg University and Department of Cardiology, Sahlgrenska University Hospital, Gothenburg, Sweden.; Department of Cardiology, Clinical Sciences, Lund University and Skåne University Hospital, Lund, Sweden.; Wallenberg Center for Molecular Medicine and Lund University Diabetes Center, Lund University, Lund, Sweden.<br /><searchLink fieldCode="AU" term="%22Söderberg+S%22">Söderberg S</searchLink>; Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.<br /><searchLink fieldCode="AU" term="%22Rader+DJ%22">Rader DJ</searchLink>; Division of Cardiovascular Medicine, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Marston+NA%22">Marston NA</searchLink>; TIMI Study Group, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Sabatine+MS%22">Sabatine MS</searchLink>; TIMI Study Group, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Pasaniuc+B%22">Pasaniuc B</searchLink>; Interdepartmental Program in Bioinformatics, University of California, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Cho+K%22">Cho K</searchLink>; Department of Medicine, Harvard Medical School, Boston, MA, USA.; MVP Boston Coordinating Center, VA Boston Healthcare System, Boston, MA, USA.; Department of Medicine, Division of Aging, Brigham and Women's Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Wilson+PWF%22">Wilson PWF</searchLink>; Atlanta VA Medical Center, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22O'Donnell+CJ%22">O'Donnell CJ</searchLink>; Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Division of Cardiology, Department of Medicine, VA Boston Healthcare System, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Stefansson+K%22">Stefansson K</searchLink>; deCODE genetics/Amgen, Inc., Reykjavik, Iceland.<br /><searchLink fieldCode="AU" term="%22Bossé+Y%22">Bossé Y</searchLink>; Institut Universitaire de Cardiologie et de Pneumologie de Québec-Université Laval, Quebec City, Quebec, Canada.; Department of Molecular Medicine, Université Laval, Quebec City, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Aikawa+E%22">Aikawa E</searchLink>; Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Center for Interdisciplinary Cardiovascular Sciences, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Engert+JC%22">Engert JC</searchLink>; McGill University Health Centre and Research Institute, Montréal, Quebec, Canada.; McGill University, Montréal, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Peloso+GM%22">Peloso GM</searchLink>; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Natarajan+P%22">Natarajan P</searchLink>; Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. pnatarajan@mgh.harvard.edu.; Broad Institute of MIT and Harvard, Cambridge, MA, USA. pnatarajan@mgh.harvard.edu.; Center for Genomic Medicine, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA. pnatarajan@mgh.harvard.edu.<br /><searchLink fieldCode="AU" term="%22Thanassoulis+G%22">Thanassoulis G</searchLink>; McGill University Health Centre and Research Institute, Montréal, Quebec, Canada. g.thanassoulis@gmail.com.; McGill University, Montréal, Quebec, Canada. g.thanassoulis@gmail.com.
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  Data: <searchLink fieldCode="CA" term="%22Colorado+Center+for+Personalized+Medicine%22">Colorado Center for Personalized Medicine</searchLink><br /><searchLink fieldCode="CA" term="%22DBDS+Genomic+Consortium%22">DBDS Genomic Consortium</searchLink><br /><searchLink fieldCode="CA" term="%22Estonian+Biobank+Research+Team%22">Estonian Biobank Research Team</searchLink><br /><searchLink fieldCode="CA" term="%22Genes+%26+Health+Research+Team%22">Genes & Health Research Team</searchLink>
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  Data: <searchLink fieldCode="JN" term="%229216904%22">Nature genetics</searchLink> [Nat Genet] 2026 Jan; Vol. 58 (1), pp. 57-66. <i>Date of Electronic Publication: </i>2025 Dec 19.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Pub%2E+Co%22">Nature Pub. Co </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9216904 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1546-1718 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2210614036%22">10614036 </searchLink><i>NLM ISO Abbreviation: </i>Nat Genet <i>Subsets: </i>MEDLINE
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      – TitleFull: Genomic and transcriptomic analyses of aortic stenosis enhance therapeutic target discovery and disease prediction.
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            NameFull: Aikawa E
      – PersonEntity:
          Name:
            NameFull: Engert JC
      – PersonEntity:
          Name:
            NameFull: Peloso GM
      – PersonEntity:
          Name:
            NameFull: Natarajan P
      – PersonEntity:
          Name:
            NameFull: Thanassoulis G
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 01
              Text: 2026 Jan
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 1546-1718
          Numbering:
            – Type: volume
              Value: 58
            – Type: issue
              Value: 1
          Titles:
            – TitleFull: Nature genetics
              Type: main
ResultId 1