Genomic and transcriptomic analyses of aortic stenosis enhance therapeutic target discovery and disease prediction.
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| Title: | Genomic and transcriptomic analyses of aortic stenosis enhance therapeutic target discovery and disease prediction. |
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| Authors: | Small AM; Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Program in Medical and Population Genetics and the Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Division of Cardiology, Department of Medicine, VA Boston Healthcare System, Boston, MA, USA., Yang TY; McGill University Health Centre and Research Institute, Montréal, Quebec, Canada.; McGill University, Montréal, Quebec, Canada.; Kyoto-McGill International Collaborative School in Genomic Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan., Itoh S; Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Center for Interdisciplinary Cardiovascular Sciences, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Thériault S; Institut Universitaire de Cardiologie et de Pneumologie de Québec-Université Laval, Quebec City, Quebec, Canada.; Department of Molecular Biology, Medical Biochemistry and Pathology, Université Laval, Quebec City, Quebec, Canada., Dufresne L; McGill University Health Centre and Research Institute, Montréal, Quebec, Canada., Kurosawa R; Laboratory for Cardiovascular Genomics and Informatics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan., Komuro I; International University of Health and Welfare, Tokyo, Japan.; Department of Frontier Cardiovascular Science, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan., Matsuda K; Institute of Medical Science, Laboratory of Genome Technology, Human Genome Center, The University of Tokyo, Tokyo, Japan., Vy HMT; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Farber-Eger EH; Department of Medicine, Division of Cardiology, Vanderbilt University Medical Center, Nashville, TN, USA., Shaffer LL; Department of Medicine, Division of Cardiology, Vanderbilt University Medical Center, Nashville, TN, USA., Boulier KM; Division of Cardiology, Department of Medicine, Ronald Reagan UCLA Medical Center, Los Angeles, CA, USA., Corey KM; Duke Molecular Physiology Institute, Duke University, Durham, NC, USA.; Department of Medicine, Duke University, Durham, NC, USA., Ramaker ME; Duke Molecular Physiology Institute, Duke University, Durham, NC, USA., Laporte F; Nantes Université, CHU Nantes, CNRS, INSERM, l'institut du Thorax, Nantes, France., Schott JJ; Nantes Université, CHU Nantes, CNRS, INSERM, l'institut du Thorax, Nantes, France., Le Scouarnec S; Nantes Université, CHU Nantes, CNRS, INSERM, l'institut du Thorax, Nantes, France., Singh SA; Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Center for Interdisciplinary Cardiovascular Sciences, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Sonawane AR; Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Center for Interdisciplinary Cardiovascular Sciences, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Smith HA; Colorado Center for Personalized Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Rafaels N; Colorado Center for Personalized Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Ghouse J; Department of Cardiology, The Heart Centre, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark., Raja AA; Department of Cardiology, The Heart Centre, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark., Ostrowski SR; Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Sørensen E; Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark., Mikkelsen C; Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark., Pedersen OB; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Clinical Immunology, Zealand University Hospital, Køge, Denmark., Erikstrup C; Department of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark., Ullum H; Statens Serum Institut, Copenhagen, Denmark., Sveinbjornsson G; deCODE genetics/Amgen, Inc., Reykjavik, Iceland., Gudbjartsson DF; deCODE genetics/Amgen, Inc., Reykjavik, Iceland., Abner E; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia., Lee J; Program in Medical and Population Genetics and the Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Harvard-MIT Health Sciences and Technology Program, Harvard Medical School, Boston, MA, USA.; Cardiovascular Research Center and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA., Ganna A; Institute for Molecular Medicine Finland, HiLIFE, University of Helsinki, Helsinki, Finland.; Analytic and Translational Genetics Unit, Boston, MA, USA., Nowak-Göttl U; Thrombosis and Hemostasis Unit, Institute of Clinical Chemistry, University Hospital Kiel, Kiel, Germany., Finer S; Wolfson Institute of Population Health, Queen Mary University of London, London, UK., Schumacher J; Institute of Human Genetics, Philipps University of Marburg, Marburg, Germany.; Institute of Human Genetics, University of Bonn and University Hospital Bonn, Bonn, Germany., Maj C; Institute of Human Genetics, Philipps University of Marburg, Marburg, Germany., Al-Kassou B; Department of Medicine II, Heart Center Bonn, University of Bonn and University Hospital Bonn, Bonn, Germany., Nickenig G; Department of Medicine II, Heart Center Bonn, University of Bonn and University Hospital Bonn, Bonn, Germany., Trenkwalder T; Department of Cardiology, German Heart Centre Munich, TUM University Hospital, School of Medicine and Health, Technical University of Munich, Munich, Germany.; DZHK (German Center for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany., Dreβen M; Department of Cardiovascular Surgery, Institute Insure, German Heart Center Munich, School of Medicine & Health, TUM University Hospital, Technical University of Munich, Munich, Germany., Krane M; DZHK (German Center for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany.; Department of Cardiovascular Surgery, Institute Insure, German Heart Center Munich, School of Medicine & Health, TUM University Hospital, Technical University of Munich, Munich, Germany.; Department of Surgery, Yale University School of Medicine, New Haven, CT, USA., Nöthen MM; Institute of Human Genetics, University of Bonn and University Hospital Bonn, Bonn, Germany., Moksnes MR; HUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, NTNU Norwegian University of Science and Technology, Trondheim, Norway., Brumpton BM; HUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, NTNU Norwegian University of Science and Technology, Trondheim, Norway.; Clinic of Medicine, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway., Knight S; Intermountain Healthcare, Salt Lake City, UT, USA., Knowlton KU; Intermountain Healthcare, Salt Lake City, UT, USA., Nadauld L; Intermountain Healthcare, Salt Lake City, UT, USA., Debiec R; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.; NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK., Musameh MD; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.; NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK., Braund PS; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.; NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK., Nelson CP; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.; NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK., Czuba T; The Wallenberg Laboratory/Department of Molecular and Clinical Medicine, Institute of Medicine and Science for Life Laboratory, Gothenburg University and Department of Cardiology, Sahlgrenska University Hospital, Gothenburg, Sweden., Melander O; Department of Internal Medicine, Clinical Sciences, Lund University and Skåne University Hospital, Malmö, Sweden., Selvaraj MS; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA., Koyama S; Program in Medical and Population Genetics and the Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Bhukar R; Program in Medical and Population Genetics and the Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Ruan Y; Program in Medical and Population Genetics and the Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Ljungberg J; Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden., Damrauer SM; Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Corporal Michael Crescenz, VA Medical Center, Philadelphia, PA, USA., Levin MG; Division of Cardiovascular Medicine, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Franke A; Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany., Berger K; Institute of Epidemiology and Social Medicine, University of Münster, Munster, Germany., Ruff CT; TIMI Study Group, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Melloni GEM; TIMI Study Group, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Kamanu FK; TIMI Study Group, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Ito K; Laboratory for Cardiovascular Genomics and Informatics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.; Department of Advanced Biomedical Data Science, Graduate School of Medicine, Chiba University, Chiba, Japan., Do R; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Loos RJF; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Science, University of Copenhagen, Copenhagen, Denmark., Schunkert H; Department of Cardiology, German Heart Centre Munich, TUM University Hospital, School of Medicine and Health, Technical University of Munich, Munich, Germany.; DZHK (German Center for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany., Wells QS; Department of Medicine, Division of Cardiology, Vanderbilt University Medical Center, Nashville, TN, USA., Shah SH; Duke Molecular Physiology Institute, Duke University, Durham, NC, USA.; Department of Medicine, Division of Cardiology, Duke University, Durham, NC, USA.; Duke Clinical Research Institute, Duke University, Durham, NC, USA., Le Tourneau T; Nantes Université, CHU Nantes, CNRS, INSERM, l'institut du Thorax, Nantes, France., Messika-Zeitoun D; Division of Cardiology, University of Ottawa Heart Institute, Ottawa, Ontario, Canada., Gignoux C; Colorado Center for Personalized Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Bundgaard H; Department of Cardiology, The Heart Centre, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark., Larsson SC; Medical Epidemiology, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.; Unit of Cardiovascular and Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden., Michaëlsson K; Medical Epidemiology, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden., Holm H; deCODE genetics/Amgen, Inc., Reykjavik, Iceland., Helgadottir A; deCODE genetics/Amgen, Inc., Reykjavik, Iceland., Esko T; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia., van Heel DA; Blizard Institute, Queen Mary University of London, London, UK., Mathieu P; Institut Universitaire de Cardiologie et de Pneumologie de Québec-Université Laval, Quebec City, Quebec, Canada.; Department of Surgery, Université Laval, Quebec City, Quebec, Canada., Samani NJ; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.; NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK., Smith JG; The Wallenberg Laboratory/Department of Molecular and Clinical Medicine, Institute of Medicine and Science for Life Laboratory, Gothenburg University and Department of Cardiology, Sahlgrenska University Hospital, Gothenburg, Sweden.; Department of Cardiology, Clinical Sciences, Lund University and Skåne University Hospital, Lund, Sweden.; Wallenberg Center for Molecular Medicine and Lund University Diabetes Center, Lund University, Lund, Sweden., Söderberg S; Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden., Rader DJ; Division of Cardiovascular Medicine, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Marston NA; TIMI Study Group, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Sabatine MS; TIMI Study Group, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Pasaniuc B; Interdepartmental Program in Bioinformatics, University of California, Los Angeles, CA, USA., Cho K; Department of Medicine, Harvard Medical School, Boston, MA, USA.; MVP Boston Coordinating Center, VA Boston Healthcare System, Boston, MA, USA.; Department of Medicine, Division of Aging, Brigham and Women's Hospital, Boston, MA, USA., Wilson PWF; Atlanta VA Medical Center, Atlanta, GA, USA., O'Donnell CJ; Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Division of Cardiology, Department of Medicine, VA Boston Healthcare System, Boston, MA, USA., Stefansson K; deCODE genetics/Amgen, Inc., Reykjavik, Iceland., Bossé Y; Institut Universitaire de Cardiologie et de Pneumologie de Québec-Université Laval, Quebec City, Quebec, Canada.; Department of Molecular Medicine, Université Laval, Quebec City, Quebec, Canada., Aikawa E; Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Center for Interdisciplinary Cardiovascular Sciences, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Engert JC; McGill University Health Centre and Research Institute, Montréal, Quebec, Canada.; McGill University, Montréal, Quebec, Canada., Peloso GM; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Natarajan P; Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. pnatarajan@mgh.harvard.edu.; Broad Institute of MIT and Harvard, Cambridge, MA, USA. pnatarajan@mgh.harvard.edu.; Center for Genomic Medicine, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA. pnatarajan@mgh.harvard.edu., Thanassoulis G; McGill University Health Centre and Research Institute, Montréal, Quebec, Canada. g.thanassoulis@gmail.com.; McGill University, Montréal, Quebec, Canada. g.thanassoulis@gmail.com. |
| Corporate Authors: | Colorado Center for Personalized Medicine, DBDS Genomic Consortium, Estonian Biobank Research Team, Genes & Health Research Team |
| Source: | Nature genetics [Nat Genet] 2026 Jan; Vol. 58 (1), pp. 57-66. Date of Electronic Publication: 2025 Dec 19. |
| Publication Type: | Journal Article; Meta-Analysis |
| Journal Info: | Publisher: Nature Pub. Co Country of Publication: United States NLM ID: 9216904 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1718 (Electronic) Linking ISSN: 10614036 NLM ISO Abbreviation: Nat Genet Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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