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A TAK1 cytokine toxicity checkpoint controls anti-cancer immunity.

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Title: A TAK1 cytokine toxicity checkpoint controls anti-cancer immunity.
Authors: Djajawi TM; Olivia Newton-John Cancer Research Institute, Heidelberg, VIC 3084, Australia; School of Cancer Medicine, La Trobe University, Melbourne, VIC 3086, Australia., Huber A; Olivia Newton-John Cancer Research Institute, Heidelberg, VIC 3084, Australia; School of Cancer Medicine, La Trobe University, Melbourne, VIC 3086, Australia., Rivera SM; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia., Srivaths A; Olivia Newton-John Cancer Research Institute, Heidelberg, VIC 3084, Australia; School of Cancer Medicine, La Trobe University, Melbourne, VIC 3086, Australia., Salehi M; Olivia Newton-John Cancer Research Institute, Heidelberg, VIC 3084, Australia; School of Cancer Medicine, La Trobe University, Melbourne, VIC 3086, Australia; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia., Gunay G; Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland., Gerak C; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia., Neil L; Olivia Newton-John Cancer Research Institute, Heidelberg, VIC 3084, Australia; School of Cancer Medicine, La Trobe University, Melbourne, VIC 3086, Australia., Ozaydin O; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia., Voulgaris O; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia., Al Halawani A; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia., Gannon D; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia., Khoshdoozmasouleh N; Olivia Newton-John Cancer Research Institute, Heidelberg, VIC 3084, Australia; School of Cancer Medicine, La Trobe University, Melbourne, VIC 3086, Australia., Jenkins LJ; Olivia Newton-John Cancer Research Institute, Heidelberg, VIC 3084, Australia; School of Cancer Medicine, La Trobe University, Melbourne, VIC 3086, Australia., Chan KF; Olivia Newton-John Cancer Research Institute, Heidelberg, VIC 3084, Australia; School of Cancer Medicine, La Trobe University, Melbourne, VIC 3086, Australia., Behren A; Olivia Newton-John Cancer Research Institute, Heidelberg, VIC 3084, Australia; School of Cancer Medicine, La Trobe University, Melbourne, VIC 3086, Australia., Ernst M; Olivia Newton-John Cancer Research Institute, Heidelberg, VIC 3084, Australia; School of Cancer Medicine, La Trobe University, Melbourne, VIC 3086, Australia., Mielke LA; Olivia Newton-John Cancer Research Institute, Heidelberg, VIC 3084, Australia; School of Cancer Medicine, La Trobe University, Melbourne, VIC 3086, Australia., Lelliott EJ; Olivia Newton-John Cancer Research Institute, Heidelberg, VIC 3084, Australia; School of Cancer Medicine, La Trobe University, Melbourne, VIC 3086, Australia., Dong H; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia., Feltham R; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia., Sutton VR; The Peter MacCallum Cancer Centre, Parkville, VIC 3052, Australia., Trapani JA; The Peter MacCallum Cancer Centre, Parkville, VIC 3052, Australia., Mariadason JM; Olivia Newton-John Cancer Research Institute, Heidelberg, VIC 3084, Australia; School of Cancer Medicine, La Trobe University, Melbourne, VIC 3086, Australia., Pal B; Olivia Newton-John Cancer Research Institute, Heidelberg, VIC 3084, Australia; School of Cancer Medicine, La Trobe University, Melbourne, VIC 3086, Australia., Martin SJ; Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland., Vervoort SJ; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia. Electronic address: vervoort.s@wehi.edu.au., Kearney CJ; Olivia Newton-John Cancer Research Institute, Heidelberg, VIC 3084, Australia; School of Cancer Medicine, La Trobe University, Melbourne, VIC 3086, Australia. Electronic address: conor.kearney@onjcri.org.au.
Source: Cell reports [Cell Rep] 2026 Jan 27; Vol. 45 (1), pp. 116665. Date of Electronic Publication: 2025 Dec 19.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE
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  Data: A TAK1 cytokine toxicity checkpoint controls anti-cancer immunity.
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  Data: <searchLink fieldCode="AU" term="%22Djajawi+TM%22">Djajawi TM</searchLink>; Olivia Newton-John Cancer Research Institute, Heidelberg, VIC 3084, Australia; School of Cancer Medicine, La Trobe University, Melbourne, VIC 3086, Australia.<br /><searchLink fieldCode="AU" term="%22Huber+A%22">Huber A</searchLink>; Olivia Newton-John Cancer Research Institute, Heidelberg, VIC 3084, Australia; School of Cancer Medicine, La Trobe University, Melbourne, VIC 3086, Australia.<br /><searchLink fieldCode="AU" term="%22Rivera+SM%22">Rivera SM</searchLink>; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia.<br /><searchLink fieldCode="AU" term="%22Srivaths+A%22">Srivaths A</searchLink>; Olivia Newton-John Cancer Research Institute, Heidelberg, VIC 3084, Australia; School of Cancer Medicine, La Trobe University, Melbourne, VIC 3086, Australia.<br /><searchLink fieldCode="AU" term="%22Salehi+M%22">Salehi M</searchLink>; Olivia Newton-John Cancer Research Institute, Heidelberg, VIC 3084, Australia; School of Cancer Medicine, La Trobe University, Melbourne, VIC 3086, Australia; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia.<br /><searchLink fieldCode="AU" term="%22Gunay+G%22">Gunay G</searchLink>; Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland.<br /><searchLink fieldCode="AU" term="%22Gerak+C%22">Gerak C</searchLink>; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia.<br /><searchLink fieldCode="AU" term="%22Neil+L%22">Neil L</searchLink>; Olivia Newton-John Cancer Research Institute, Heidelberg, VIC 3084, Australia; School of Cancer Medicine, La Trobe University, Melbourne, VIC 3086, Australia.<br /><searchLink fieldCode="AU" term="%22Ozaydin+O%22">Ozaydin O</searchLink>; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia.<br /><searchLink fieldCode="AU" term="%22Voulgaris+O%22">Voulgaris O</searchLink>; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia.<br /><searchLink fieldCode="AU" term="%22Al+Halawani+A%22">Al Halawani A</searchLink>; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia.<br /><searchLink fieldCode="AU" term="%22Gannon+D%22">Gannon D</searchLink>; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia.<br /><searchLink fieldCode="AU" term="%22Khoshdoozmasouleh+N%22">Khoshdoozmasouleh N</searchLink>; Olivia Newton-John Cancer Research Institute, Heidelberg, VIC 3084, Australia; School of Cancer Medicine, La Trobe University, Melbourne, VIC 3086, Australia.<br /><searchLink fieldCode="AU" term="%22Jenkins+LJ%22">Jenkins LJ</searchLink>; Olivia Newton-John Cancer Research Institute, Heidelberg, VIC 3084, Australia; School of Cancer Medicine, La Trobe University, Melbourne, VIC 3086, Australia.<br /><searchLink fieldCode="AU" term="%22Chan+KF%22">Chan KF</searchLink>; Olivia Newton-John Cancer Research Institute, Heidelberg, VIC 3084, Australia; School of Cancer Medicine, La Trobe University, Melbourne, VIC 3086, Australia.<br /><searchLink fieldCode="AU" term="%22Behren+A%22">Behren A</searchLink>; Olivia Newton-John Cancer Research Institute, Heidelberg, VIC 3084, Australia; School of Cancer Medicine, La Trobe University, Melbourne, VIC 3086, Australia.<br /><searchLink fieldCode="AU" term="%22Ernst+M%22">Ernst M</searchLink>; Olivia Newton-John Cancer Research Institute, Heidelberg, VIC 3084, Australia; School of Cancer Medicine, La Trobe University, Melbourne, VIC 3086, Australia.<br /><searchLink fieldCode="AU" term="%22Mielke+LA%22">Mielke LA</searchLink>; Olivia Newton-John Cancer Research Institute, Heidelberg, VIC 3084, Australia; School of Cancer Medicine, La Trobe University, Melbourne, VIC 3086, Australia.<br /><searchLink fieldCode="AU" term="%22Lelliott+EJ%22">Lelliott EJ</searchLink>; Olivia Newton-John Cancer Research Institute, Heidelberg, VIC 3084, Australia; School of Cancer Medicine, La Trobe University, Melbourne, VIC 3086, Australia.<br /><searchLink fieldCode="AU" term="%22Dong+H%22">Dong H</searchLink>; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia.<br /><searchLink fieldCode="AU" term="%22Feltham+R%22">Feltham R</searchLink>; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia.<br /><searchLink fieldCode="AU" term="%22Sutton+VR%22">Sutton VR</searchLink>; The Peter MacCallum Cancer Centre, Parkville, VIC 3052, Australia.<br /><searchLink fieldCode="AU" term="%22Trapani+JA%22">Trapani JA</searchLink>; The Peter MacCallum Cancer Centre, Parkville, VIC 3052, Australia.<br /><searchLink fieldCode="AU" term="%22Mariadason+JM%22">Mariadason JM</searchLink>; Olivia Newton-John Cancer Research Institute, Heidelberg, VIC 3084, Australia; School of Cancer Medicine, La Trobe University, Melbourne, VIC 3086, Australia.<br /><searchLink fieldCode="AU" term="%22Pal+B%22">Pal B</searchLink>; Olivia Newton-John Cancer Research Institute, Heidelberg, VIC 3084, Australia; School of Cancer Medicine, La Trobe University, Melbourne, VIC 3086, Australia.<br /><searchLink fieldCode="AU" term="%22Martin+SJ%22">Martin SJ</searchLink>; Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland.<br /><searchLink fieldCode="AU" term="%22Vervoort+SJ%22">Vervoort SJ</searchLink>; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia. Electronic address: vervoort.s@wehi.edu.au.<br /><searchLink fieldCode="AU" term="%22Kearney+CJ%22">Kearney CJ</searchLink>; Olivia Newton-John Cancer Research Institute, Heidelberg, VIC 3084, Australia; School of Cancer Medicine, La Trobe University, Melbourne, VIC 3086, Australia. Electronic address: conor.kearney@onjcri.org.au.
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  Data: <searchLink fieldCode="JN" term="%22101573691%22">Cell reports</searchLink> [Cell Rep] 2026 Jan 27; Vol. 45 (1), pp. 116665. <i>Date of Electronic Publication: </i>2025 Dec 19.
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