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Pharmacological increases in circulating ketones fail to alleviate the hypertrophic cardiomyopathy present in the Tafazzin knockdown mouse model of Barth syndrome.

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Title: Pharmacological increases in circulating ketones fail to alleviate the hypertrophic cardiomyopathy present in the Tafazzin knockdown mouse model of Barth syndrome.
Authors: Shafaati T; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada.; Cardiovascular Research Centre, University of Alberta, Edmonton, AB, Canada.; Women and Children's Health Research Institute, University of Alberta, Edmonton, AB, Canada., Greenwell AA; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada.; Cardiovascular Research Centre, University of Alberta, Edmonton, AB, Canada.; Women and Children's Health Research Institute, University of Alberta, Edmonton, AB, Canada., Saed CT; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada.; Cardiovascular Research Centre, University of Alberta, Edmonton, AB, Canada.; Women and Children's Health Research Institute, University of Alberta, Edmonton, AB, Canada., Tabatabaei Dakhili SA; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada.; Cardiovascular Research Centre, University of Alberta, Edmonton, AB, Canada.; Women and Children's Health Research Institute, University of Alberta, Edmonton, AB, Canada., Chan JSF; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada.; Cardiovascular Research Centre, University of Alberta, Edmonton, AB, Canada.; Women and Children's Health Research Institute, University of Alberta, Edmonton, AB, Canada., Dong L; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada.; Cardiovascular Research Centre, University of Alberta, Edmonton, AB, Canada., Stenlund MJ; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada.; Cardiovascular Research Centre, University of Alberta, Edmonton, AB, Canada.; Women and Children's Health Research Institute, University of Alberta, Edmonton, AB, Canada., Ferrari SR; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada.; Cardiovascular Research Centre, University of Alberta, Edmonton, AB, Canada.; Women and Children's Health Research Institute, University of Alberta, Edmonton, AB, Canada., Han R; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada.; Cardiovascular Research Centre, University of Alberta, Edmonton, AB, Canada., Kruger J; Health Sciences Laboratory Animal Services, University of Alberta, Edmonton, AB, Canada., Eaton F; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada.; Cardiovascular Research Centre, University of Alberta, Edmonton, AB, Canada.; Women and Children's Health Research Institute, University of Alberta, Edmonton, AB, Canada., Gopal K; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada.; Cardiovascular Research Centre, University of Alberta, Edmonton, AB, Canada.; Women and Children's Health Research Institute, University of Alberta, Edmonton, AB, Canada., Davidge ST; Cardiovascular Research Centre, University of Alberta, Edmonton, AB, Canada.; Women and Children's Health Research Institute, University of Alberta, Edmonton, AB, Canada.; Department of Obstetrics and Gynaecology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada., Oudit GY; Cardiovascular Research Centre, University of Alberta, Edmonton, AB, Canada.; Divsion of Cardiology, Department of Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada.; Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, AB, Canada., Ussher JR; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada.; Cardiovascular Research Centre, University of Alberta, Edmonton, AB, Canada.; Women and Children's Health Research Institute, University of Alberta, Edmonton, AB, Canada.
Source: Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques [J Pharm Pharm Sci] 2025 Dec 04; Vol. 28, pp. 15688. Date of Electronic Publication: 2025 Dec 04 (Print Publication: 2025).
Publication Type: Journal Article
Journal Info: Publisher: Frontiers Media S. A Country of Publication: Switzerland NLM ID: 9807281 Publication Model: eCollection Cited Medium: Internet ISSN: 1482-1826 (Electronic) Linking ISSN: 14821826 NLM ISO Abbreviation: J Pharm Pharm Sci Subsets: MEDLINE
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  Data: Pharmacological increases in circulating ketones fail to alleviate the hypertrophic cardiomyopathy present in the Tafazzin knockdown mouse model of Barth syndrome.
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