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Integrated genomic analysis and CRISPRi implicates EGFR in Alzheimer's disease risk.

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Title: Integrated genomic analysis and CRISPRi implicates EGFR in Alzheimer's disease risk.
Authors: Leung YY; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA USA., Kuksa PP; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA USA., Carter L; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA USA., Cifello J; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA USA., Greenfest-Allen E; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA USA., Valladares O; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA USA., Boateng L; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA USA., Laub S; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA USA., Tulina N; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA USA., Moura S; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL USA., Ramirez A; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL USA., Celis K; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL USA., Jin F; Department of Genetics and Genome Sciences, School of Medicine, Case Western Reserve University, Cleveland, OH USA., Feng R; Center for Statistical Genetics, The Gertrude H. Sergievsky Center, Columbia University, New York, NY USA.; Department of Neurology, Columbia University, New York, NY USA., Wang G; Center for Statistical Genetics, The Gertrude H. Sergievsky Center, Columbia University, New York, NY USA.; Department of Neurology, Columbia University, New York, NY USA., De Jager P; Center for Statistical Genetics, The Gertrude H. Sergievsky Center, Columbia University, New York, NY USA.; Department of Neurology, Columbia University, New York, NY USA., Vance JM; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL USA., Wang L; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL USA., Grant SFA; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA USA.; Center for Spatial and Functional Genomics, The Children's Hospital of Philadelphia, Philadelphia, PA USA.; Divisions of Human Genetics and Endocrinology & Diabetes, The Children's Hospital of Philadelphia, Philadelphia, PA USA.; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA USA.; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA USA., Schellenberg GD; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA USA., Chesi A; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA USA.; Center for Spatial and Functional Genomics, The Children's Hospital of Philadelphia, Philadelphia, PA USA., Wang LS; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA USA.
Source: NPJ dementia [NPJ Dement] 2025; Vol. 1 (1), pp. 42. Date of Electronic Publication: 2025 Dec 16.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 9918993995206676 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 3005-1940 (Electronic) Linking ISSN: 30051940 NLM ISO Abbreviation: NPJ Dement Subsets: PubMed not MEDLINE
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  Data: Integrated genomic analysis and CRISPRi implicates EGFR in Alzheimer's disease risk.
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  Data: <searchLink fieldCode="AU" term="%22Leung+YY%22">Leung YY</searchLink>; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA USA.<br /><searchLink fieldCode="AU" term="%22Kuksa+PP%22">Kuksa PP</searchLink>; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA USA.<br /><searchLink fieldCode="AU" term="%22Carter+L%22">Carter L</searchLink>; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA USA.<br /><searchLink fieldCode="AU" term="%22Cifello+J%22">Cifello J</searchLink>; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA USA.<br /><searchLink fieldCode="AU" term="%22Greenfest-Allen+E%22">Greenfest-Allen E</searchLink>; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA USA.<br /><searchLink fieldCode="AU" term="%22Valladares+O%22">Valladares O</searchLink>; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA USA.<br /><searchLink fieldCode="AU" term="%22Boateng+L%22">Boateng L</searchLink>; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA USA.<br /><searchLink fieldCode="AU" term="%22Laub+S%22">Laub S</searchLink>; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA USA.<br /><searchLink fieldCode="AU" term="%22Tulina+N%22">Tulina N</searchLink>; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA USA.<br /><searchLink fieldCode="AU" term="%22Moura+S%22">Moura S</searchLink>; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL USA.<br /><searchLink fieldCode="AU" term="%22Ramirez+A%22">Ramirez A</searchLink>; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL USA.<br /><searchLink fieldCode="AU" term="%22Celis+K%22">Celis K</searchLink>; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL USA.<br /><searchLink fieldCode="AU" term="%22Jin+F%22">Jin F</searchLink>; Department of Genetics and Genome Sciences, School of Medicine, Case Western Reserve University, Cleveland, OH USA.<br /><searchLink fieldCode="AU" term="%22Feng+R%22">Feng R</searchLink>; Center for Statistical Genetics, The Gertrude H. Sergievsky Center, Columbia University, New York, NY USA.; Department of Neurology, Columbia University, New York, NY USA.<br /><searchLink fieldCode="AU" term="%22Wang+G%22">Wang G</searchLink>; Center for Statistical Genetics, The Gertrude H. Sergievsky Center, Columbia University, New York, NY USA.; Department of Neurology, Columbia University, New York, NY USA.<br /><searchLink fieldCode="AU" term="%22De+Jager+P%22">De Jager P</searchLink>; Center for Statistical Genetics, The Gertrude H. Sergievsky Center, Columbia University, New York, NY USA.; Department of Neurology, Columbia University, New York, NY USA.<br /><searchLink fieldCode="AU" term="%22Vance+JM%22">Vance JM</searchLink>; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL USA.<br /><searchLink fieldCode="AU" term="%22Wang+L%22">Wang L</searchLink>; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL USA.<br /><searchLink fieldCode="AU" term="%22Grant+SFA%22">Grant SFA</searchLink>; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA USA.; Center for Spatial and Functional Genomics, The Children's Hospital of Philadelphia, Philadelphia, PA USA.; Divisions of Human Genetics and Endocrinology & Diabetes, The Children's Hospital of Philadelphia, Philadelphia, PA USA.; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA USA.; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA USA.<br /><searchLink fieldCode="AU" term="%22Schellenberg+GD%22">Schellenberg GD</searchLink>; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA USA.<br /><searchLink fieldCode="AU" term="%22Chesi+A%22">Chesi A</searchLink>; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA USA.; Center for Spatial and Functional Genomics, The Children's Hospital of Philadelphia, Philadelphia, PA USA.<br /><searchLink fieldCode="AU" term="%22Wang+LS%22">Wang LS</searchLink>; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA USA.
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      – TitleFull: Integrated genomic analysis and CRISPRi implicates EGFR in Alzheimer's disease risk.
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