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Alkylation-based optimization of antifungal FPPS inhibitors yields a potent, broad-spectrum lipophilic zoledronate derivative.

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Title: Alkylation-based optimization of antifungal FPPS inhibitors yields a potent, broad-spectrum lipophilic zoledronate derivative.
Authors: Kane A; School of Life and Environmental Sciences, The University of Sydney, Sydney, NSW, Australia., Lai F; School of Pharmacy, The University of Sydney, Sydney, NSW, Australia., Rothwell JG; School of Life and Environmental Sciences, The University of Sydney, Sydney, NSW, Australia., Dinh TTH; School of Natural Sciences, ARC Centre of Excellence in Synthetic Biology, Macquarie University, Sydney, NSW, Australia., Campbell L; School of Life and Environmental Sciences, The University of Sydney, Sydney, NSW, Australia., Cain AK; School of Natural Sciences, ARC Centre of Excellence in Synthetic Biology, Macquarie University, Sydney, NSW, Australia., Hibbs D; School of Pharmacy, The University of Sydney, Sydney, NSW, Australia., Hanrahan J; School of Pharmacy, The University of Sydney, Sydney, NSW, Australia., Carter D; School of Life and Environmental Sciences, The University of Sydney, Sydney, NSW, Australia.; Sydney Institute for Infectious Diseases, University of Sydney, Sydney, NSW, Australia.
Source: MBio [mBio] 2026 Feb 11; Vol. 17 (2), pp. e0319925. Date of Electronic Publication: 2025 Dec 22.
Publication Type: Journal Article
Journal Info: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 101519231 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2150-7511 (Electronic) NLM ISO Abbreviation: mBio Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Alkylation-based optimization of antifungal FPPS inhibitors yields a potent, broad-spectrum lipophilic zoledronate derivative.
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  Data: <searchLink fieldCode="AU" term="%22Kane+A%22">Kane A</searchLink>; School of Life and Environmental Sciences, The University of Sydney, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Lai+F%22">Lai F</searchLink>; School of Pharmacy, The University of Sydney, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Rothwell+JG%22">Rothwell JG</searchLink>; School of Life and Environmental Sciences, The University of Sydney, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Dinh+TTH%22">Dinh TTH</searchLink>; School of Natural Sciences, ARC Centre of Excellence in Synthetic Biology, Macquarie University, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Campbell+L%22">Campbell L</searchLink>; School of Life and Environmental Sciences, The University of Sydney, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Cain+AK%22">Cain AK</searchLink>; School of Natural Sciences, ARC Centre of Excellence in Synthetic Biology, Macquarie University, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Hibbs+D%22">Hibbs D</searchLink>; School of Pharmacy, The University of Sydney, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Hanrahan+J%22">Hanrahan J</searchLink>; School of Pharmacy, The University of Sydney, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Carter+D%22">Carter D</searchLink>; School of Life and Environmental Sciences, The University of Sydney, Sydney, NSW, Australia.; Sydney Institute for Infectious Diseases, University of Sydney, Sydney, NSW, Australia.
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  Data: <searchLink fieldCode="JN" term="%22101519231%22">MBio</searchLink> [mBio] 2026 Feb 11; Vol. 17 (2), pp. e0319925. <i>Date of Electronic Publication: </i>2025 Dec 22.
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        Value: 10.1128/mbio.03199-25
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              Text: 2026 Feb 11
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