Alkylation-based optimization of antifungal FPPS inhibitors yields a potent, broad-spectrum lipophilic zoledronate derivative.
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| Title: | Alkylation-based optimization of antifungal FPPS inhibitors yields a potent, broad-spectrum lipophilic zoledronate derivative. |
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| Authors: | Kane A; School of Life and Environmental Sciences, The University of Sydney, Sydney, NSW, Australia., Lai F; School of Pharmacy, The University of Sydney, Sydney, NSW, Australia., Rothwell JG; School of Life and Environmental Sciences, The University of Sydney, Sydney, NSW, Australia., Dinh TTH; School of Natural Sciences, ARC Centre of Excellence in Synthetic Biology, Macquarie University, Sydney, NSW, Australia., Campbell L; School of Life and Environmental Sciences, The University of Sydney, Sydney, NSW, Australia., Cain AK; School of Natural Sciences, ARC Centre of Excellence in Synthetic Biology, Macquarie University, Sydney, NSW, Australia., Hibbs D; School of Pharmacy, The University of Sydney, Sydney, NSW, Australia., Hanrahan J; School of Pharmacy, The University of Sydney, Sydney, NSW, Australia., Carter D; School of Life and Environmental Sciences, The University of Sydney, Sydney, NSW, Australia.; Sydney Institute for Infectious Diseases, University of Sydney, Sydney, NSW, Australia. |
| Source: | MBio [mBio] 2026 Feb 11; Vol. 17 (2), pp. e0319925. Date of Electronic Publication: 2025 Dec 22. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 101519231 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2150-7511 (Electronic) NLM ISO Abbreviation: mBio Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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