Schisandrin C alleviates depressive-like behaviors by modulating the AKT/CREB/BDNF pathway, the serotonin pathway of tryptophan metabolism, and the gut microbiota composition.
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| Title: | Schisandrin C alleviates depressive-like behaviors by modulating the AKT/CREB/BDNF pathway, the serotonin pathway of tryptophan metabolism, and the gut microbiota composition. |
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| Authors: | Tran SH; Center for Natural Product Systems Biology, Natural Product Drug Development Division, Korea Institute of Science and Technology, Gangneung, Gangwon-do, 25451, South Korea; Natural Product Applied Science, KIST School, University of Science and Technology (UST), Gangneung, Gangwon-do, 25451, South Korea., Zhang S; Center for Natural Product Efficacy Optimization, Natural Product Drug Development Division, Korea Institute of Science and Technology, Gangneung, Gangwon-do, 25451, South Korea; Natural Product Applied Science, KIST School, University of Science and Technology (UST), Gangneung, Gangwon-do, 25451, South Korea., Lee HS; Center for Natural Product Systems Biology, Natural Product Drug Development Division, Korea Institute of Science and Technology, Gangneung, Gangwon-do, 25451, South Korea., Hitayezu E; Center for Natural Product Systems Biology, Natural Product Drug Development Division, Korea Institute of Science and Technology, Gangneung, Gangwon-do, 25451, South Korea., Nguyen UTT; Center for Natural Product Systems Biology, Natural Product Drug Development Division, Korea Institute of Science and Technology, Gangneung, Gangwon-do, 25451, South Korea; Natural Product Applied Science, KIST School, University of Science and Technology (UST), Gangneung, Gangwon-do, 25451, South Korea., Lee S; Center for Natural Product Systems Biology, Natural Product Drug Development Division, Korea Institute of Science and Technology, Gangneung, Gangwon-do, 25451, South Korea; Natural Product Applied Science, KIST School, University of Science and Technology (UST), Gangneung, Gangwon-do, 25451, South Korea., Kang SW; Center for Natural Product Efficacy Optimization, Natural Product Drug Development Division, Korea Institute of Science and Technology, Gangneung, Gangwon-do, 25451, South Korea., Park K; Center for Natural Product Systems Biology, Natural Product Drug Development Division, Korea Institute of Science and Technology, Gangneung, Gangwon-do, 25451, South Korea., Kim SH; Department of Food Bioscience and Technology, College of Life Sciences and Biotechnology, Korea University, Seoul, 02841, South Korea., Kwon HC; Center for Natural Product Systems Biology, Natural Product Drug Development Division, Korea Institute of Science and Technology, Gangneung, Gangwon-do, 25451, South Korea., Cha K; Center for Natural Product Systems Biology, Natural Product Drug Development Division, Korea Institute of Science and Technology, Gangneung, Gangwon-do, 25451, South Korea; Natural Product Applied Science, KIST School, University of Science and Technology (UST), Gangneung, Gangwon-do, 25451, South Korea. Electronic address: chakh79@kist.re.kr., Kwon J; Center for Natural Product Systems Biology, Natural Product Drug Development Division, Korea Institute of Science and Technology, Gangneung, Gangwon-do, 25451, South Korea; Natural Product Applied Science, KIST School, University of Science and Technology (UST), Gangneung, Gangwon-do, 25451, South Korea. Electronic address: kjy1207@kist.re.kr., Kim J; Center for Natural Product Efficacy Optimization, Natural Product Drug Development Division, Korea Institute of Science and Technology, Gangneung, Gangwon-do, 25451, South Korea; Natural Product Applied Science, KIST School, University of Science and Technology (UST), Gangneung, Gangwon-do, 25451, South Korea. Electronic address: need2pro@kist.re.kr., Kang K; Center for Natural Product Systems Biology, Natural Product Drug Development Division, Korea Institute of Science and Technology, Gangneung, Gangwon-do, 25451, South Korea; Natural Product Applied Science, KIST School, University of Science and Technology (UST), Gangneung, Gangwon-do, 25451, South Korea. Electronic address: kskang@kist.re.kr. |
| Source: | Phytomedicine : international journal of phytotherapy and phytopharmacology [Phytomedicine] 2026 Jan; Vol. 150, pp. 157581. Date of Electronic Publication: 2025 Nov 23. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Urban & Fischer Verlag Country of Publication: Germany NLM ID: 9438794 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1618-095X (Electronic) Linking ISSN: 09447113 NLM ISO Abbreviation: Phytomedicine Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41435604 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Schisandrin C alleviates depressive-like behaviors by modulating the AKT/CREB/BDNF pathway, the serotonin pathway of tryptophan metabolism, and the gut microbiota composition. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Tran+SH%22">Tran SH</searchLink>; Center for Natural Product Systems Biology, Natural Product Drug Development Division, Korea Institute of Science and Technology, Gangneung, Gangwon-do, 25451, South Korea; Natural Product Applied Science, KIST School, University of Science and Technology (UST), Gangneung, Gangwon-do, 25451, South Korea.<br /><searchLink fieldCode="AU" term="%22Zhang+S%22">Zhang S</searchLink>; Center for Natural Product Efficacy Optimization, Natural Product Drug Development Division, Korea Institute of Science and Technology, Gangneung, Gangwon-do, 25451, South Korea; Natural Product Applied Science, KIST School, University of Science and Technology (UST), Gangneung, Gangwon-do, 25451, South Korea.<br /><searchLink fieldCode="AU" term="%22Lee+HS%22">Lee HS</searchLink>; Center for Natural Product Systems Biology, Natural Product Drug Development Division, Korea Institute of Science and Technology, Gangneung, Gangwon-do, 25451, South Korea.<br /><searchLink fieldCode="AU" term="%22Hitayezu+E%22">Hitayezu E</searchLink>; Center for Natural Product Systems Biology, Natural Product Drug Development Division, Korea Institute of Science and Technology, Gangneung, Gangwon-do, 25451, South Korea.<br /><searchLink fieldCode="AU" term="%22Nguyen+UTT%22">Nguyen UTT</searchLink>; Center for Natural Product Systems Biology, Natural Product Drug Development Division, Korea Institute of Science and Technology, Gangneung, Gangwon-do, 25451, South Korea; Natural Product Applied Science, KIST School, University of Science and Technology (UST), Gangneung, Gangwon-do, 25451, South Korea.<br /><searchLink fieldCode="AU" term="%22Lee+S%22">Lee S</searchLink>; Center for Natural Product Systems Biology, Natural Product Drug Development Division, Korea Institute of Science and Technology, Gangneung, Gangwon-do, 25451, South Korea; Natural Product Applied Science, KIST School, University of Science and Technology (UST), Gangneung, Gangwon-do, 25451, South Korea.<br /><searchLink fieldCode="AU" term="%22Kang+SW%22">Kang SW</searchLink>; Center for Natural Product Efficacy Optimization, Natural Product Drug Development Division, Korea Institute of Science and Technology, Gangneung, Gangwon-do, 25451, South Korea.<br /><searchLink fieldCode="AU" term="%22Park+K%22">Park K</searchLink>; Center for Natural Product Systems Biology, Natural Product Drug Development Division, Korea Institute of Science and Technology, Gangneung, Gangwon-do, 25451, South Korea.<br /><searchLink fieldCode="AU" term="%22Kim+SH%22">Kim SH</searchLink>; Department of Food Bioscience and Technology, College of Life Sciences and Biotechnology, Korea University, Seoul, 02841, South Korea.<br /><searchLink fieldCode="AU" term="%22Kwon+HC%22">Kwon HC</searchLink>; Center for Natural Product Systems Biology, Natural Product Drug Development Division, Korea Institute of Science and Technology, Gangneung, Gangwon-do, 25451, South Korea.<br /><searchLink fieldCode="AU" term="%22Cha+K%22">Cha K</searchLink>; Center for Natural Product Systems Biology, Natural Product Drug Development Division, Korea Institute of Science and Technology, Gangneung, Gangwon-do, 25451, South Korea; Natural Product Applied Science, KIST School, University of Science and Technology (UST), Gangneung, Gangwon-do, 25451, South Korea. Electronic address: chakh79@kist.re.kr.<br /><searchLink fieldCode="AU" term="%22Kwon+J%22">Kwon J</searchLink>; Center for Natural Product Systems Biology, Natural Product Drug Development Division, Korea Institute of Science and Technology, Gangneung, Gangwon-do, 25451, South Korea; Natural Product Applied Science, KIST School, University of Science and Technology (UST), Gangneung, Gangwon-do, 25451, South Korea. Electronic address: kjy1207@kist.re.kr.<br /><searchLink fieldCode="AU" term="%22Kim+J%22">Kim J</searchLink>; Center for Natural Product Efficacy Optimization, Natural Product Drug Development Division, Korea Institute of Science and Technology, Gangneung, Gangwon-do, 25451, South Korea; Natural Product Applied Science, KIST School, University of Science and Technology (UST), Gangneung, Gangwon-do, 25451, South Korea. Electronic address: need2pro@kist.re.kr.<br /><searchLink fieldCode="AU" term="%22Kang+K%22">Kang K</searchLink>; Center for Natural Product Systems Biology, Natural Product Drug Development Division, Korea Institute of Science and Technology, Gangneung, Gangwon-do, 25451, South Korea; Natural Product Applied Science, KIST School, University of Science and Technology (UST), Gangneung, Gangwon-do, 25451, South Korea. Electronic address: kskang@kist.re.kr. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%229438794%22">Phytomedicine : international journal of phytotherapy and phytopharmacology</searchLink> [Phytomedicine] 2026 Jan; Vol. 150, pp. 157581. <i>Date of Electronic Publication: </i>2025 Nov 23. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Urban+%26+Fischer+Verlag%22">Urban & Fischer Verlag </searchLink><i>Country of Publication: </i>Germany <i>NLM ID: </i>9438794 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1618-095X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2209447113%22">09447113 </searchLink><i>NLM ISO Abbreviation: </i>Phytomedicine <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41435604 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/j.phymed.2025.157581 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 157581 Titles: – TitleFull: Schisandrin C alleviates depressive-like behaviors by modulating the AKT/CREB/BDNF pathway, the serotonin pathway of tryptophan metabolism, and the gut microbiota composition. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Tran SH – PersonEntity: Name: NameFull: Zhang S – PersonEntity: Name: NameFull: Lee HS – PersonEntity: Name: NameFull: Hitayezu E – PersonEntity: Name: NameFull: Nguyen UTT – PersonEntity: Name: NameFull: Lee S – PersonEntity: Name: NameFull: Kang SW – PersonEntity: Name: NameFull: Park K – PersonEntity: Name: NameFull: Kim SH – PersonEntity: Name: NameFull: Kwon HC – PersonEntity: Name: NameFull: Cha K – PersonEntity: Name: NameFull: Kwon J – PersonEntity: Name: NameFull: Kim J – PersonEntity: Name: NameFull: Kang K IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 01 Text: 2026 Jan Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 1618-095X Numbering: – Type: volume Value: 150 Titles: – TitleFull: Phytomedicine : international journal of phytotherapy and phytopharmacology Type: main |
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