Schisandrin C alleviates depressive-like behaviors by modulating the AKT/CREB/BDNF pathway, the serotonin pathway of tryptophan metabolism, and the gut microbiota composition.
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| Title: | Schisandrin C alleviates depressive-like behaviors by modulating the AKT/CREB/BDNF pathway, the serotonin pathway of tryptophan metabolism, and the gut microbiota composition. |
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| Authors: | Tran SH; Center for Natural Product Systems Biology, Natural Product Drug Development Division, Korea Institute of Science and Technology, Gangneung, Gangwon-do, 25451, South Korea; Natural Product Applied Science, KIST School, University of Science and Technology (UST), Gangneung, Gangwon-do, 25451, South Korea., Zhang S; Center for Natural Product Efficacy Optimization, Natural Product Drug Development Division, Korea Institute of Science and Technology, Gangneung, Gangwon-do, 25451, South Korea; Natural Product Applied Science, KIST School, University of Science and Technology (UST), Gangneung, Gangwon-do, 25451, South Korea., Lee HS; Center for Natural Product Systems Biology, Natural Product Drug Development Division, Korea Institute of Science and Technology, Gangneung, Gangwon-do, 25451, South Korea., Hitayezu E; Center for Natural Product Systems Biology, Natural Product Drug Development Division, Korea Institute of Science and Technology, Gangneung, Gangwon-do, 25451, South Korea., Nguyen UTT; Center for Natural Product Systems Biology, Natural Product Drug Development Division, Korea Institute of Science and Technology, Gangneung, Gangwon-do, 25451, South Korea; Natural Product Applied Science, KIST School, University of Science and Technology (UST), Gangneung, Gangwon-do, 25451, South Korea., Lee S; Center for Natural Product Systems Biology, Natural Product Drug Development Division, Korea Institute of Science and Technology, Gangneung, Gangwon-do, 25451, South Korea; Natural Product Applied Science, KIST School, University of Science and Technology (UST), Gangneung, Gangwon-do, 25451, South Korea., Kang SW; Center for Natural Product Efficacy Optimization, Natural Product Drug Development Division, Korea Institute of Science and Technology, Gangneung, Gangwon-do, 25451, South Korea., Park K; Center for Natural Product Systems Biology, Natural Product Drug Development Division, Korea Institute of Science and Technology, Gangneung, Gangwon-do, 25451, South Korea., Kim SH; Department of Food Bioscience and Technology, College of Life Sciences and Biotechnology, Korea University, Seoul, 02841, South Korea., Kwon HC; Center for Natural Product Systems Biology, Natural Product Drug Development Division, Korea Institute of Science and Technology, Gangneung, Gangwon-do, 25451, South Korea., Cha K; Center for Natural Product Systems Biology, Natural Product Drug Development Division, Korea Institute of Science and Technology, Gangneung, Gangwon-do, 25451, South Korea; Natural Product Applied Science, KIST School, University of Science and Technology (UST), Gangneung, Gangwon-do, 25451, South Korea. Electronic address: chakh79@kist.re.kr., Kwon J; Center for Natural Product Systems Biology, Natural Product Drug Development Division, Korea Institute of Science and Technology, Gangneung, Gangwon-do, 25451, South Korea; Natural Product Applied Science, KIST School, University of Science and Technology (UST), Gangneung, Gangwon-do, 25451, South Korea. Electronic address: kjy1207@kist.re.kr., Kim J; Center for Natural Product Efficacy Optimization, Natural Product Drug Development Division, Korea Institute of Science and Technology, Gangneung, Gangwon-do, 25451, South Korea; Natural Product Applied Science, KIST School, University of Science and Technology (UST), Gangneung, Gangwon-do, 25451, South Korea. Electronic address: need2pro@kist.re.kr., Kang K; Center for Natural Product Systems Biology, Natural Product Drug Development Division, Korea Institute of Science and Technology, Gangneung, Gangwon-do, 25451, South Korea; Natural Product Applied Science, KIST School, University of Science and Technology (UST), Gangneung, Gangwon-do, 25451, South Korea. Electronic address: kskang@kist.re.kr. |
| Source: | Phytomedicine : international journal of phytotherapy and phytopharmacology [Phytomedicine] 2026 Jan; Vol. 150, pp. 157581. Date of Electronic Publication: 2025 Nov 23. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Urban & Fischer Verlag Country of Publication: Germany NLM ID: 9438794 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1618-095X (Electronic) Linking ISSN: 09447113 NLM ISO Abbreviation: Phytomedicine Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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