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The relationship between genotype- and phenotype-based estimates of genetic liability to psychiatric disorders, in practice and in theory.

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Title: The relationship between genotype- and phenotype-based estimates of genetic liability to psychiatric disorders, in practice and in theory.
Authors: Dybdahl Krebs M; Institute of Biological Psychiatry, Mental Health Center - Sct Hans, Copenhagen University Hospital - Mental Health Services CPH, Copenhagen, Denmark. Electronic address: morten.dybdahl.krebs@regionh.dk., Appadurai V; Institute of Biological Psychiatry, Mental Health Center - Sct Hans, Copenhagen University Hospital - Mental Health Services CPH, Copenhagen, Denmark., Georgii Hellberg KL; Institute of Biological Psychiatry, Mental Health Center - Sct Hans, Copenhagen University Hospital - Mental Health Services CPH, Copenhagen, Denmark., Ohlsson H; Center for Primary Health Care Research, Lund University, Malmö, Sweden., Steinbach J; NCRR - National Centre for Register-Based Research, Business and Social Sciences, Aarhus University, Aarhus V, Denmark., Pedersen E; NCRR - National Centre for Register-Based Research, Business and Social Sciences, Aarhus University, Aarhus V, Denmark., Werge T; Institute of Biological Psychiatry, Mental Health Center - Sct Hans, Copenhagen University Hospital - Mental Health Services CPH, Copenhagen, Denmark; Section for Geogenetics, GLOBE Institute, Faculty of Health and Medical Science, Copenhagen University, Copenhagen, Denmark., Sundquist J; Center for Primary Health Care Research, Lund University, Malmö, Sweden., Sundquist K; Center for Primary Health Care Research, Lund University, Malmö, Sweden., Border R; Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA; Department of Computer Science, University of California, Los Angeles, Los Angeles, CA, USA; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Cai N; Helmholtz Pioneer Campus, Helmholtz Zentrum München, Neuherberg, Germany., Zaitlen N; Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA; Department of Computational Medicine, University of California, Los Angeles, Los Angeles, CA, USA., Dahl A; Section of Genetic Medicine, Department of Medicine, University of Chicago, Chicago, IL, USA., Vilhjalmsson B; NCRR - National Centre for Register-Based Research, Business and Social Sciences, Aarhus University, Aarhus V, Denmark; Department of Biomedicine, Aarhus University, Aarhus, Denmark., Flint J; Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA., Bacanu SA; Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA; Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA., Kendler KS; Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA; Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA., Schork AJ; Institute of Biological Psychiatry, Mental Health Center - Sct Hans, Copenhagen University Hospital - Mental Health Services CPH, Copenhagen, Denmark; Section for Geogenetics, GLOBE Institute, Faculty of Health and Medical Science, Copenhagen University, Copenhagen, Denmark. Electronic address: andrew.joseph.schork@regionh.dk.
Corporate Authors: iPSYCH Study Consortium
Source: American journal of human genetics [Am J Hum Genet] 2026 Jan 08; Vol. 113 (1), pp. 184-201. Date of Electronic Publication: 2025 Dec 22.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 0370475 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1537-6605 (Electronic) Linking ISSN: 00029297 NLM ISO Abbreviation: Am J Hum Genet Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Dybdahl+Krebs+M%22">Dybdahl Krebs M</searchLink>; Institute of Biological Psychiatry, Mental Health Center - Sct Hans, Copenhagen University Hospital - Mental Health Services CPH, Copenhagen, Denmark. Electronic address: morten.dybdahl.krebs@regionh.dk.<br /><searchLink fieldCode="AU" term="%22Appadurai+V%22">Appadurai V</searchLink>; Institute of Biological Psychiatry, Mental Health Center - Sct Hans, Copenhagen University Hospital - Mental Health Services CPH, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Georgii+Hellberg+KL%22">Georgii Hellberg KL</searchLink>; Institute of Biological Psychiatry, Mental Health Center - Sct Hans, Copenhagen University Hospital - Mental Health Services CPH, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Ohlsson+H%22">Ohlsson H</searchLink>; Center for Primary Health Care Research, Lund University, Malmö, Sweden.<br /><searchLink fieldCode="AU" term="%22Steinbach+J%22">Steinbach J</searchLink>; NCRR - National Centre for Register-Based Research, Business and Social Sciences, Aarhus University, Aarhus V, Denmark.<br /><searchLink fieldCode="AU" term="%22Pedersen+E%22">Pedersen E</searchLink>; NCRR - National Centre for Register-Based Research, Business and Social Sciences, Aarhus University, Aarhus V, Denmark.<br /><searchLink fieldCode="AU" term="%22Werge+T%22">Werge T</searchLink>; Institute of Biological Psychiatry, Mental Health Center - Sct Hans, Copenhagen University Hospital - Mental Health Services CPH, Copenhagen, Denmark; Section for Geogenetics, GLOBE Institute, Faculty of Health and Medical Science, Copenhagen University, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Sundquist+J%22">Sundquist J</searchLink>; Center for Primary Health Care Research, Lund University, Malmö, Sweden.<br /><searchLink fieldCode="AU" term="%22Sundquist+K%22">Sundquist K</searchLink>; Center for Primary Health Care Research, Lund University, Malmö, Sweden.<br /><searchLink fieldCode="AU" term="%22Border+R%22">Border R</searchLink>; Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA; Department of Computer Science, University of California, Los Angeles, Los Angeles, CA, USA; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Cai+N%22">Cai N</searchLink>; Helmholtz Pioneer Campus, Helmholtz Zentrum München, Neuherberg, Germany.<br /><searchLink fieldCode="AU" term="%22Zaitlen+N%22">Zaitlen N</searchLink>; Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA; Department of Computational Medicine, University of California, Los Angeles, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Dahl+A%22">Dahl A</searchLink>; Section of Genetic Medicine, Department of Medicine, University of Chicago, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Vilhjalmsson+B%22">Vilhjalmsson B</searchLink>; NCRR - National Centre for Register-Based Research, Business and Social Sciences, Aarhus University, Aarhus V, Denmark; Department of Biomedicine, Aarhus University, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Flint+J%22">Flint J</searchLink>; Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Bacanu+SA%22">Bacanu SA</searchLink>; Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA; Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA.<br /><searchLink fieldCode="AU" term="%22Kendler+KS%22">Kendler KS</searchLink>; Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA; Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA.<br /><searchLink fieldCode="AU" term="%22Schork+AJ%22">Schork AJ</searchLink>; Institute of Biological Psychiatry, Mental Health Center - Sct Hans, Copenhagen University Hospital - Mental Health Services CPH, Copenhagen, Denmark; Section for Geogenetics, GLOBE Institute, Faculty of Health and Medical Science, Copenhagen University, Copenhagen, Denmark. Electronic address: andrew.joseph.schork@regionh.dk.
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