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Pluripotent stem cells-based neural organoids for modelling human brain development and diseases.

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Title: Pluripotent stem cells-based neural organoids for modelling human brain development and diseases.
Authors: Tong L; Center for Reproductive Medicine of The Second Affiliated Hospital, Center for Regeneration and Cell Therapy of Zhejiang, University-University of Edinburgh Institute (ZJU-UoE Institute), Zhejiang University School of Medicine, Zhejiang University, Hangzhou, 310003, Zhejiang, China., Tian P; Center for Reproductive Medicine of The Second Affiliated Hospital, Center for Regeneration and Cell Therapy of Zhejiang, University-University of Edinburgh Institute (ZJU-UoE Institute), Zhejiang University School of Medicine, Zhejiang University, Hangzhou, 310003, Zhejiang, China.; Edinburgh Medical School: Biomedical Sciences, College of Medicine and Veterinary Medicine, The University of Edinburgh, Edinburgh, UK., Wang R; Center for Reproductive Medicine of The Second Affiliated Hospital, Center for Regeneration and Cell Therapy of Zhejiang, University-University of Edinburgh Institute (ZJU-UoE Institute), Zhejiang University School of Medicine, Zhejiang University, Hangzhou, 310003, Zhejiang, China.; Edinburgh Medical School: Biomedical Sciences, College of Medicine and Veterinary Medicine, The University of Edinburgh, Edinburgh, UK., Niu S; Center for Reproductive Medicine of The Second Affiliated Hospital, Center for Regeneration and Cell Therapy of Zhejiang, University-University of Edinburgh Institute (ZJU-UoE Institute), Zhejiang University School of Medicine, Zhejiang University, Hangzhou, 310003, Zhejiang, China.; Edinburgh Medical School: Biomedical Sciences, College of Medicine and Veterinary Medicine, The University of Edinburgh, Edinburgh, UK., Wang R; Center for Reproductive Medicine of The Second Affiliated Hospital, Center for Regeneration and Cell Therapy of Zhejiang, University-University of Edinburgh Institute (ZJU-UoE Institute), Zhejiang University School of Medicine, Zhejiang University, Hangzhou, 310003, Zhejiang, China.; Edinburgh Medical School: Biomedical Sciences, College of Medicine and Veterinary Medicine, The University of Edinburgh, Edinburgh, UK., Ye Y; Center for Reproductive Medicine of The Second Affiliated Hospital, Center for Regeneration and Cell Therapy of Zhejiang, University-University of Edinburgh Institute (ZJU-UoE Institute), Zhejiang University School of Medicine, Zhejiang University, Hangzhou, 310003, Zhejiang, China., Wu Y; Center for Reproductive Medicine of The Second Affiliated Hospital, Center for Regeneration and Cell Therapy of Zhejiang, University-University of Edinburgh Institute (ZJU-UoE Institute), Zhejiang University School of Medicine, Zhejiang University, Hangzhou, 310003, Zhejiang, China.; Edinburgh Medical School: Biomedical Sciences, College of Medicine and Veterinary Medicine, The University of Edinburgh, Edinburgh, UK., Zhang W; Center for Reproductive Medicine of The Second Affiliated Hospital, Center for Regeneration and Cell Therapy of Zhejiang, University-University of Edinburgh Institute (ZJU-UoE Institute), Zhejiang University School of Medicine, Zhejiang University, Hangzhou, 310003, Zhejiang, China., Wang Y; Center for Reproductive Medicine of The Second Affiliated Hospital, Center for Regeneration and Cell Therapy of Zhejiang, University-University of Edinburgh Institute (ZJU-UoE Institute), Zhejiang University School of Medicine, Zhejiang University, Hangzhou, 310003, Zhejiang, China., Foggetti A; Edinburgh Medical School: Biomedical Sciences, College of Medicine and Veterinary Medicine, The University of Edinburgh, Edinburgh, UK. foggetti@intl.zju.edu.cn.; Neurology Department of The Second Affiliated Hospital, Centre for Biomedical Systems and Informatics of Zhejiang, University-University of Edinburgh Institute (ZJU-UoE Institute), Zhejiang University School of Medicine, Zhejiang University, Hangzhou, 310003, Zhejiang, China. foggetti@intl.zju.edu.cn., Chen D; Center for Reproductive Medicine of The Second Affiliated Hospital, Center for Regeneration and Cell Therapy of Zhejiang, University-University of Edinburgh Institute (ZJU-UoE Institute), Zhejiang University School of Medicine, Zhejiang University, Hangzhou, 310003, Zhejiang, China. dichen@intl.zju.edu.cn.; Edinburgh Medical School: Biomedical Sciences, College of Medicine and Veterinary Medicine, The University of Edinburgh, Edinburgh, UK. dichen@intl.zju.edu.cn.; State Key Laboratory of Biobased Transportation Fuel Technology, Haining, 314400, Zhejiang, China. dichen@intl.zju.edu.cn.; Dr. Li Dak Sum and Yip Yio Chin Center for Stem Cell and Regenerative Medicine, Zhejiang University, Hangzhou, 310003, Zhejiang, China. dichen@intl.zju.edu.cn.; Zhejiang Key Laboratory of Medical Imaging Artificial Intelligence, Haining, 314400, Zhejiang, China. dichen@intl.zju.edu.cn.; Biomedical and Health Translational Research Center of Zhejiang Province, Haining, 314400, Zhejiang, China. dichen@intl.zju.edu.cn.
Source: Cell & bioscience [Cell Biosci] 2025 Dec 24; Vol. 16 (1), pp. 20. Date of Electronic Publication: 2025 Dec 24.
Publication Type: Journal Article; Review
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101561195 Publication Model: Electronic Cited Medium: Print ISSN: 2045-3701 (Print) Linking ISSN: 20453701 NLM ISO Abbreviation: Cell Biosci Subsets: PubMed not MEDLINE
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  Data: Pluripotent stem cells-based neural organoids for modelling human brain development and diseases.
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  Data: <searchLink fieldCode="AU" term="%22Tong+L%22">Tong L</searchLink>; Center for Reproductive Medicine of The Second Affiliated Hospital, Center for Regeneration and Cell Therapy of Zhejiang, University-University of Edinburgh Institute (ZJU-UoE Institute), Zhejiang University School of Medicine, Zhejiang University, Hangzhou, 310003, Zhejiang, China.<br /><searchLink fieldCode="AU" term="%22Tian+P%22">Tian P</searchLink>; Center for Reproductive Medicine of The Second Affiliated Hospital, Center for Regeneration and Cell Therapy of Zhejiang, University-University of Edinburgh Institute (ZJU-UoE Institute), Zhejiang University School of Medicine, Zhejiang University, Hangzhou, 310003, Zhejiang, China.; Edinburgh Medical School: Biomedical Sciences, College of Medicine and Veterinary Medicine, The University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Wang+R%22">Wang R</searchLink>; Center for Reproductive Medicine of The Second Affiliated Hospital, Center for Regeneration and Cell Therapy of Zhejiang, University-University of Edinburgh Institute (ZJU-UoE Institute), Zhejiang University School of Medicine, Zhejiang University, Hangzhou, 310003, Zhejiang, China.; Edinburgh Medical School: Biomedical Sciences, College of Medicine and Veterinary Medicine, The University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Niu+S%22">Niu S</searchLink>; Center for Reproductive Medicine of The Second Affiliated Hospital, Center for Regeneration and Cell Therapy of Zhejiang, University-University of Edinburgh Institute (ZJU-UoE Institute), Zhejiang University School of Medicine, Zhejiang University, Hangzhou, 310003, Zhejiang, China.; Edinburgh Medical School: Biomedical Sciences, College of Medicine and Veterinary Medicine, The University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Wang+R%22">Wang R</searchLink>; Center for Reproductive Medicine of The Second Affiliated Hospital, Center for Regeneration and Cell Therapy of Zhejiang, University-University of Edinburgh Institute (ZJU-UoE Institute), Zhejiang University School of Medicine, Zhejiang University, Hangzhou, 310003, Zhejiang, China.; Edinburgh Medical School: Biomedical Sciences, College of Medicine and Veterinary Medicine, The University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Ye+Y%22">Ye Y</searchLink>; Center for Reproductive Medicine of The Second Affiliated Hospital, Center for Regeneration and Cell Therapy of Zhejiang, University-University of Edinburgh Institute (ZJU-UoE Institute), Zhejiang University School of Medicine, Zhejiang University, Hangzhou, 310003, Zhejiang, China.<br /><searchLink fieldCode="AU" term="%22Wu+Y%22">Wu Y</searchLink>; Center for Reproductive Medicine of The Second Affiliated Hospital, Center for Regeneration and Cell Therapy of Zhejiang, University-University of Edinburgh Institute (ZJU-UoE Institute), Zhejiang University School of Medicine, Zhejiang University, Hangzhou, 310003, Zhejiang, China.; Edinburgh Medical School: Biomedical Sciences, College of Medicine and Veterinary Medicine, The University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Zhang+W%22">Zhang W</searchLink>; Center for Reproductive Medicine of The Second Affiliated Hospital, Center for Regeneration and Cell Therapy of Zhejiang, University-University of Edinburgh Institute (ZJU-UoE Institute), Zhejiang University School of Medicine, Zhejiang University, Hangzhou, 310003, Zhejiang, China.<br /><searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; Center for Reproductive Medicine of The Second Affiliated Hospital, Center for Regeneration and Cell Therapy of Zhejiang, University-University of Edinburgh Institute (ZJU-UoE Institute), Zhejiang University School of Medicine, Zhejiang University, Hangzhou, 310003, Zhejiang, China.<br /><searchLink fieldCode="AU" term="%22Foggetti+A%22">Foggetti A</searchLink>; Edinburgh Medical School: Biomedical Sciences, College of Medicine and Veterinary Medicine, The University of Edinburgh, Edinburgh, UK. foggetti@intl.zju.edu.cn.; Neurology Department of The Second Affiliated Hospital, Centre for Biomedical Systems and Informatics of Zhejiang, University-University of Edinburgh Institute (ZJU-UoE Institute), Zhejiang University School of Medicine, Zhejiang University, Hangzhou, 310003, Zhejiang, China. foggetti@intl.zju.edu.cn.<br /><searchLink fieldCode="AU" term="%22Chen+D%22">Chen D</searchLink>; Center for Reproductive Medicine of The Second Affiliated Hospital, Center for Regeneration and Cell Therapy of Zhejiang, University-University of Edinburgh Institute (ZJU-UoE Institute), Zhejiang University School of Medicine, Zhejiang University, Hangzhou, 310003, Zhejiang, China. dichen@intl.zju.edu.cn.; Edinburgh Medical School: Biomedical Sciences, College of Medicine and Veterinary Medicine, The University of Edinburgh, Edinburgh, UK. dichen@intl.zju.edu.cn.; State Key Laboratory of Biobased Transportation Fuel Technology, Haining, 314400, Zhejiang, China. dichen@intl.zju.edu.cn.; Dr. Li Dak Sum and Yip Yio Chin Center for Stem Cell and Regenerative Medicine, Zhejiang University, Hangzhou, 310003, Zhejiang, China. dichen@intl.zju.edu.cn.; Zhejiang Key Laboratory of Medical Imaging Artificial Intelligence, Haining, 314400, Zhejiang, China. dichen@intl.zju.edu.cn.; Biomedical and Health Translational Research Center of Zhejiang Province, Haining, 314400, Zhejiang, China. dichen@intl.zju.edu.cn.
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        Value: 10.1186/s13578-025-01515-6
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              Text: 2025 Dec 24
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