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Genetic activation of ERK2 recapitulates core neurodevelopmental features of Rasopathy syndromes in mice.

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Title: Genetic activation of ERK2 recapitulates core neurodevelopmental features of Rasopathy syndromes in mice.
Authors: Grover KE; Division of Experimental Hematology and Cancer Biology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, United States., Cappel ZR; Division of Experimental Hematology and Cancer Biology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, United States., Volz A; Division of Experimental Hematology and Cancer Biology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, United States., Cotella EM; Department of Functional and Systems Neuroscience, Instituto Mercedes y Martin Ferreyra INIMEC-CONICET, Universidad Nacional de Córdoba, Córdoba, Argentina., Smallwood K; The Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, United States., Berryhill CA; Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, 46202, United States., Raje KR; Department of Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, United States., Fisher AA; Division of Experimental Hematology and Cancer Biology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, United States., Casper MCT; Division of Experimental Hematology and Cancer Biology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, United States., Nardini D; Division of Experimental Hematology and Cancer Biology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, United States., Rizvi TA; Division of Experimental Hematology and Cancer Biology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, United States., Salazar RM; Division of Experimental Hematology and Cancer Biology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, United States., Wooten A; Division of Experimental Hematology and Cancer Biology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, United States., Williams MT; Department of Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, United States.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, 45229, United States., Vorhees CV; Department of Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, United States.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, 45229, United States., Romick LE; Division of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, 45229, United States.; University of Cincinnati Cancer Center, University of Cincinnati College of Medicine, Cincinnati, OH, 45229, United States., Greis KD; University of Cincinnati Cancer Center, University of Cincinnati College of Medicine, Cincinnati, OH, 45229, United States.; Department of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, OH, 45229, United States., Hu YC; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, 45229, United States.; Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, United States., Miles LA; Division of Experimental Hematology and Cancer Biology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, United States.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, 45229, United States.; University of Cincinnati Cancer Center, University of Cincinnati College of Medicine, Cincinnati, OH, 45229, United States., Angus SP; Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, 46202, United States., Ratner N; Division of Experimental Hematology and Cancer Biology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, United States.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, 45229, United States.; University of Cincinnati Cancer Center, University of Cincinnati College of Medicine, Cincinnati, OH, 45229, United States., Prada CE; Edwards Family Division of Genetics and Rare Diseases, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, 60611, United States.; Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, United States., Weaver KN; The Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, United States.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, 45229, United States.; Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, United States., Waclaw RR; Division of Experimental Hematology and Cancer Biology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, United States.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, 45229, United States.; University of Cincinnati Cancer Center, University of Cincinnati College of Medicine, Cincinnati, OH, 45229, United States.; Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, United States., Robinson JE; Division of Experimental Hematology and Cancer Biology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, United States.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, 45229, United States.; University of Cincinnati Cancer Center, University of Cincinnati College of Medicine, Cincinnati, OH, 45229, United States.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2025 Dec 19. Date of Electronic Publication: 2025 Dec 19.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: Genetic activation of ERK2 recapitulates core neurodevelopmental features of Rasopathy syndromes in mice.
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  Data: <searchLink fieldCode="AU" term="%22Grover+KE%22">Grover KE</searchLink>; Division of Experimental Hematology and Cancer Biology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, United States.<br /><searchLink fieldCode="AU" term="%22Cappel+ZR%22">Cappel ZR</searchLink>; Division of Experimental Hematology and Cancer Biology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, United States.<br /><searchLink fieldCode="AU" term="%22Volz+A%22">Volz A</searchLink>; Division of Experimental Hematology and Cancer Biology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, United States.<br /><searchLink fieldCode="AU" term="%22Cotella+EM%22">Cotella EM</searchLink>; Department of Functional and Systems Neuroscience, Instituto Mercedes y Martin Ferreyra INIMEC-CONICET, Universidad Nacional de Córdoba, Córdoba, Argentina.<br /><searchLink fieldCode="AU" term="%22Smallwood+K%22">Smallwood K</searchLink>; The Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, United States.<br /><searchLink fieldCode="AU" term="%22Berryhill+CA%22">Berryhill CA</searchLink>; Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, 46202, United States.<br /><searchLink fieldCode="AU" term="%22Raje+KR%22">Raje KR</searchLink>; Department of Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, United States.<br /><searchLink fieldCode="AU" term="%22Fisher+AA%22">Fisher AA</searchLink>; Division of Experimental Hematology and Cancer Biology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, United States.<br /><searchLink fieldCode="AU" term="%22Casper+MCT%22">Casper MCT</searchLink>; Division of Experimental Hematology and Cancer Biology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, United States.<br /><searchLink fieldCode="AU" term="%22Nardini+D%22">Nardini D</searchLink>; Division of Experimental Hematology and Cancer Biology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, United States.<br /><searchLink fieldCode="AU" term="%22Rizvi+TA%22">Rizvi TA</searchLink>; Division of Experimental Hematology and Cancer Biology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, United States.<br /><searchLink fieldCode="AU" term="%22Salazar+RM%22">Salazar RM</searchLink>; Division of Experimental Hematology and Cancer Biology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, United States.<br /><searchLink fieldCode="AU" term="%22Wooten+A%22">Wooten A</searchLink>; Division of Experimental Hematology and Cancer Biology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, United States.<br /><searchLink fieldCode="AU" term="%22Williams+MT%22">Williams MT</searchLink>; Department of Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, United States.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, 45229, United States.<br /><searchLink fieldCode="AU" term="%22Vorhees+CV%22">Vorhees CV</searchLink>; Department of Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, United States.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, 45229, United States.<br /><searchLink fieldCode="AU" term="%22Romick+LE%22">Romick LE</searchLink>; Division of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, 45229, United States.; University of Cincinnati Cancer Center, University of Cincinnati College of Medicine, Cincinnati, OH, 45229, United States.<br /><searchLink fieldCode="AU" term="%22Greis+KD%22">Greis KD</searchLink>; University of Cincinnati Cancer Center, University of Cincinnati College of Medicine, Cincinnati, OH, 45229, United States.; Department of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, OH, 45229, United States.<br /><searchLink fieldCode="AU" term="%22Hu+YC%22">Hu YC</searchLink>; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, 45229, United States.; Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, United States.<br /><searchLink fieldCode="AU" term="%22Miles+LA%22">Miles LA</searchLink>; Division of Experimental Hematology and Cancer Biology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, United States.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, 45229, United States.; University of Cincinnati Cancer Center, University of Cincinnati College of Medicine, Cincinnati, OH, 45229, United States.<br /><searchLink fieldCode="AU" term="%22Angus+SP%22">Angus SP</searchLink>; Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, 46202, United States.<br /><searchLink fieldCode="AU" term="%22Ratner+N%22">Ratner N</searchLink>; Division of Experimental Hematology and Cancer Biology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, United States.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, 45229, United States.; University of Cincinnati Cancer Center, University of Cincinnati College of Medicine, Cincinnati, OH, 45229, United States.<br /><searchLink fieldCode="AU" term="%22Prada+CE%22">Prada CE</searchLink>; Edwards Family Division of Genetics and Rare Diseases, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, 60611, United States.; Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, United States.<br /><searchLink fieldCode="AU" term="%22Weaver+KN%22">Weaver KN</searchLink>; The Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, United States.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, 45229, United States.; Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, United States.<br /><searchLink fieldCode="AU" term="%22Waclaw+RR%22">Waclaw RR</searchLink>; Division of Experimental Hematology and Cancer Biology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, United States.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, 45229, United States.; University of Cincinnati Cancer Center, University of Cincinnati College of Medicine, Cincinnati, OH, 45229, United States.; Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, United States.<br /><searchLink fieldCode="AU" term="%22Robinson+JE%22">Robinson JE</searchLink>; Division of Experimental Hematology and Cancer Biology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, United States.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, 45229, United States.; University of Cincinnati Cancer Center, University of Cincinnati College of Medicine, Cincinnati, OH, 45229, United States.
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