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LncRNA H19 Upregulation Links Hypoplastic Left Heart Syndrome to Impaired PINK1/Parkin-Mediated Mitophagy and Ischemic Vulnerability.

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Title: LncRNA H19 Upregulation Links Hypoplastic Left Heart Syndrome to Impaired PINK1/Parkin-Mediated Mitophagy and Ischemic Vulnerability.
Authors: Fu X; Cardiovascular-Thoracic Surgery and the Heart Center, Stanley Manne Children's Research Institute, Ann & Robert H. Lurie Children's Hospital of Chicago, Departments of Pediatrics and Surgery, Feinberg School of Medicine, Northwestern University, 225 E. Chicago Avenue, Chicago, Illinois 60611., Epting CL; Departments of Pediatrics and Pathology, Ann & Robert H. Lurie Children's Hospital of Chicago, Feinberg School of Medicine, Northwestern University, 225 E. Chicago Avenue, Chicago, Illinois 60611., Sinha A; Cardiovascular-Thoracic Surgery and the Heart Center, Stanley Manne Children's Research Institute, Ann & Robert H. Lurie Children's Hospital of Chicago, Departments of Pediatrics and Surgery, Feinberg School of Medicine, Northwestern University, 225 E. Chicago Avenue, Chicago, Illinois 60611., Mongé MC; Cardiovascular-Thoracic Surgery and the Heart Center, Stanley Manne Children's Research Institute, Ann & Robert H. Lurie Children's Hospital of Chicago, Departments of Pediatrics and Surgery, Feinberg School of Medicine, Northwestern University, 225 E. Chicago Avenue, Chicago, Illinois 60611., Zhao M; The Feinberg Cardiovascular and Renal Research Institute, Department of Medicine, Feinberg School of Medicine, Northwestern University, 300 E. Superior Street, Chicago, Illinois 60611., Glinton KE; Department of Pathology, Feinberg School of Medicine, Northwestern University, 303 E. Chicago Avenue, Chicago, Illinois 60611., Krishnan ST; Cardiovascular-Thoracic Surgery and the Heart Center, Stanley Manne Children's Research Institute, Ann & Robert H. Lurie Children's Hospital of Chicago, Departments of Pediatrics and Surgery, Feinberg School of Medicine, Northwestern University, 225 E. Chicago Avenue, Chicago, Illinois 60611., Nguyen MLT; Stanley Manne Children's Research Institute, Ann & Robert H. Lurie Children's Hospital of Chicago, Department of Pediatrics, Feinberg School of Medicine, Northwestern University, 303 E. Superior Street, Chicago, Illinois 60611., Dudley VJ; Stanley Manne Children's Research Institute, Ann & Robert H. Lurie Children's Hospital of Chicago, Department of Pediatrics, Feinberg School of Medicine, Northwestern University, 303 E. Superior Street, Chicago, Illinois 60611., Waypa GB; Stanley Manne Children's Research Institute, Ann & Robert H. Lurie Children's Hospital of Chicago, Department of Pediatrics, Feinberg School of Medicine, Northwestern University, 303 E. Superior Street, Chicago, Illinois 60611., Lara PG; Cardiovascular-Thoracic Surgery and the Heart Center, Stanley Manne Children's Research Institute, Ann & Robert H. Lurie Children's Hospital of Chicago, Departments of Pediatrics and Surgery, Feinberg School of Medicine, Northwestern University, 225 E. Chicago Avenue, Chicago, Illinois 60611., Kishawi T; Departments of Pediatrics and Pathology, Ann & Robert H. Lurie Children's Hospital of Chicago, Feinberg School of Medicine, Northwestern University, 225 E. Chicago Avenue, Chicago, Illinois 60611., Lantz CW; Departments of Surgery, Comprehensive Transplant Center, Feinberg School of Medicine, Northwestern University, 676 N. St. Clair Street, Chicago, IL 60611., Winlaw D; Cardiovascular-Thoracic Surgery and the Heart Center, Stanley Manne Children's Research Institute, Ann & Robert H. Lurie Children's Hospital of Chicago, Departments of Pediatrics and Surgery, Feinberg School of Medicine, Northwestern University, 225 E. Chicago Avenue, Chicago, Illinois 60611., Schumacker PT; Stanley Manne Children's Research Institute, Ann & Robert H. Lurie Children's Hospital of Chicago, Department of Pediatrics, Feinberg School of Medicine, Northwestern University, 303 E. Superior Street, Chicago, Illinois 60611., Thorp EB; Department of Pathology, Feinberg School of Medicine, Northwestern University, 303 E. Chicago Avenue, Chicago, Illinois 60611., Ge ZD; Cardiovascular-Thoracic Surgery and the Heart Center, Stanley Manne Children's Research Institute, Ann & Robert H. Lurie Children's Hospital of Chicago, Departments of Pediatrics and Surgery, Feinberg School of Medicine, Northwestern University, 225 E. Chicago Avenue, Chicago, Illinois 60611.; Stanley Manne Children's Research Institute, Ann & Robert H. Lurie Children's Hospital of Chicago, Department of Pediatrics, Feinberg School of Medicine, Northwestern University, 303 E. Superior Street, Chicago, Illinois 60611.; Departments of Anesthesiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, Wisconsin 53206.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2025 Dec 19. Date of Electronic Publication: 2025 Dec 19.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: LncRNA H19 Upregulation Links Hypoplastic Left Heart Syndrome to Impaired PINK1/Parkin-Mediated Mitophagy and Ischemic Vulnerability.
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  Data: <searchLink fieldCode="AU" term="%22Fu+X%22">Fu X</searchLink>; Cardiovascular-Thoracic Surgery and the Heart Center, Stanley Manne Children's Research Institute, Ann & Robert H. Lurie Children's Hospital of Chicago, Departments of Pediatrics and Surgery, Feinberg School of Medicine, Northwestern University, 225 E. Chicago Avenue, Chicago, Illinois 60611.<br /><searchLink fieldCode="AU" term="%22Epting+CL%22">Epting CL</searchLink>; Departments of Pediatrics and Pathology, Ann & Robert H. Lurie Children's Hospital of Chicago, Feinberg School of Medicine, Northwestern University, 225 E. Chicago Avenue, Chicago, Illinois 60611.<br /><searchLink fieldCode="AU" term="%22Sinha+A%22">Sinha A</searchLink>; Cardiovascular-Thoracic Surgery and the Heart Center, Stanley Manne Children's Research Institute, Ann & Robert H. Lurie Children's Hospital of Chicago, Departments of Pediatrics and Surgery, Feinberg School of Medicine, Northwestern University, 225 E. Chicago Avenue, Chicago, Illinois 60611.<br /><searchLink fieldCode="AU" term="%22Mongé+MC%22">Mongé MC</searchLink>; Cardiovascular-Thoracic Surgery and the Heart Center, Stanley Manne Children's Research Institute, Ann & Robert H. Lurie Children's Hospital of Chicago, Departments of Pediatrics and Surgery, Feinberg School of Medicine, Northwestern University, 225 E. Chicago Avenue, Chicago, Illinois 60611.<br /><searchLink fieldCode="AU" term="%22Zhao+M%22">Zhao M</searchLink>; The Feinberg Cardiovascular and Renal Research Institute, Department of Medicine, Feinberg School of Medicine, Northwestern University, 300 E. Superior Street, Chicago, Illinois 60611.<br /><searchLink fieldCode="AU" term="%22Glinton+KE%22">Glinton KE</searchLink>; Department of Pathology, Feinberg School of Medicine, Northwestern University, 303 E. Chicago Avenue, Chicago, Illinois 60611.<br /><searchLink fieldCode="AU" term="%22Krishnan+ST%22">Krishnan ST</searchLink>; Cardiovascular-Thoracic Surgery and the Heart Center, Stanley Manne Children's Research Institute, Ann & Robert H. Lurie Children's Hospital of Chicago, Departments of Pediatrics and Surgery, Feinberg School of Medicine, Northwestern University, 225 E. Chicago Avenue, Chicago, Illinois 60611.<br /><searchLink fieldCode="AU" term="%22Nguyen+MLT%22">Nguyen MLT</searchLink>; Stanley Manne Children's Research Institute, Ann & Robert H. Lurie Children's Hospital of Chicago, Department of Pediatrics, Feinberg School of Medicine, Northwestern University, 303 E. Superior Street, Chicago, Illinois 60611.<br /><searchLink fieldCode="AU" term="%22Dudley+VJ%22">Dudley VJ</searchLink>; Stanley Manne Children's Research Institute, Ann & Robert H. Lurie Children's Hospital of Chicago, Department of Pediatrics, Feinberg School of Medicine, Northwestern University, 303 E. Superior Street, Chicago, Illinois 60611.<br /><searchLink fieldCode="AU" term="%22Waypa+GB%22">Waypa GB</searchLink>; Stanley Manne Children's Research Institute, Ann & Robert H. Lurie Children's Hospital of Chicago, Department of Pediatrics, Feinberg School of Medicine, Northwestern University, 303 E. Superior Street, Chicago, Illinois 60611.<br /><searchLink fieldCode="AU" term="%22Lara+PG%22">Lara PG</searchLink>; Cardiovascular-Thoracic Surgery and the Heart Center, Stanley Manne Children's Research Institute, Ann & Robert H. Lurie Children's Hospital of Chicago, Departments of Pediatrics and Surgery, Feinberg School of Medicine, Northwestern University, 225 E. Chicago Avenue, Chicago, Illinois 60611.<br /><searchLink fieldCode="AU" term="%22Kishawi+T%22">Kishawi T</searchLink>; Departments of Pediatrics and Pathology, Ann & Robert H. Lurie Children's Hospital of Chicago, Feinberg School of Medicine, Northwestern University, 225 E. Chicago Avenue, Chicago, Illinois 60611.<br /><searchLink fieldCode="AU" term="%22Lantz+CW%22">Lantz CW</searchLink>; Departments of Surgery, Comprehensive Transplant Center, Feinberg School of Medicine, Northwestern University, 676 N. St. Clair Street, Chicago, IL 60611.<br /><searchLink fieldCode="AU" term="%22Winlaw+D%22">Winlaw D</searchLink>; Cardiovascular-Thoracic Surgery and the Heart Center, Stanley Manne Children's Research Institute, Ann & Robert H. Lurie Children's Hospital of Chicago, Departments of Pediatrics and Surgery, Feinberg School of Medicine, Northwestern University, 225 E. Chicago Avenue, Chicago, Illinois 60611.<br /><searchLink fieldCode="AU" term="%22Schumacker+PT%22">Schumacker PT</searchLink>; Stanley Manne Children's Research Institute, Ann & Robert H. Lurie Children's Hospital of Chicago, Department of Pediatrics, Feinberg School of Medicine, Northwestern University, 303 E. Superior Street, Chicago, Illinois 60611.<br /><searchLink fieldCode="AU" term="%22Thorp+EB%22">Thorp EB</searchLink>; Department of Pathology, Feinberg School of Medicine, Northwestern University, 303 E. Chicago Avenue, Chicago, Illinois 60611.<br /><searchLink fieldCode="AU" term="%22Ge+ZD%22">Ge ZD</searchLink>; Cardiovascular-Thoracic Surgery and the Heart Center, Stanley Manne Children's Research Institute, Ann & Robert H. Lurie Children's Hospital of Chicago, Departments of Pediatrics and Surgery, Feinberg School of Medicine, Northwestern University, 225 E. Chicago Avenue, Chicago, Illinois 60611.; Stanley Manne Children's Research Institute, Ann & Robert H. Lurie Children's Hospital of Chicago, Department of Pediatrics, Feinberg School of Medicine, Northwestern University, 303 E. Superior Street, Chicago, Illinois 60611.; Departments of Anesthesiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, Wisconsin 53206.
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