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Emerging small-molecule AKR1C3 inhibitors development for cancer therapy: Progress from 2021 to 2025.

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Title: Emerging small-molecule AKR1C3 inhibitors development for cancer therapy: Progress from 2021 to 2025.
Authors: Gao HN; Provincial Engineering Laboratory for Screening and Re-evaluation of Active Compounds of Herbal Medicines in Southern Anhui, School of Pharmacy, Wannan Medical College, Wuhu, 241000, PR China., Wu XS; Provincial Engineering Laboratory for Screening and Re-evaluation of Active Compounds of Herbal Medicines in Southern Anhui, School of Pharmacy, Wannan Medical College, Wuhu, 241000, PR China., Pan ZJ; Provincial Engineering Laboratory for Screening and Re-evaluation of Active Compounds of Herbal Medicines in Southern Anhui, School of Pharmacy, Wannan Medical College, Wuhu, 241000, PR China., Liu HM; Provincial Engineering Laboratory for Screening and Re-evaluation of Active Compounds of Herbal Medicines in Southern Anhui, School of Pharmacy, Wannan Medical College, Wuhu, 241000, PR China., Chen KQ; Provincial Engineering Laboratory for Screening and Re-evaluation of Active Compounds of Herbal Medicines in Southern Anhui, School of Pharmacy, Wannan Medical College, Wuhu, 241000, PR China., Teng MX; Provincial Engineering Laboratory for Screening and Re-evaluation of Active Compounds of Herbal Medicines in Southern Anhui, School of Pharmacy, Wannan Medical College, Wuhu, 241000, PR China., Zhao JT; School of Pharmacy & State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, 730000, PR China., Zhou J; Provincial Engineering Laboratory for Screening and Re-evaluation of Active Compounds of Herbal Medicines in Southern Anhui, School of Pharmacy, Wannan Medical College, Wuhu, 241000, PR China; Center for Reproductive Medicine, The First Affiliated Hospital of Wannan Medical College, Wuhu, 241000, PR China., You QD; Jiangsu Key Laboratory of Drug Design and Optimization and State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 210009, PR China; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, PR China. Electronic address: youqd@163.com., Zhang C; Provincial Engineering Laboratory for Screening and Re-evaluation of Active Compounds of Herbal Medicines in Southern Anhui, School of Pharmacy, Wannan Medical College, Wuhu, 241000, PR China. Electronic address: zhangchao@wnmc.edu.cn.
Source: European journal of medicinal chemistry [Eur J Med Chem] 2026 Feb 15; Vol. 304, pp. 118490. Date of Electronic Publication: 2025 Dec 15.
Publication Type: Journal Article; Review
Journal Info: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Emerging small-molecule AKR1C3 inhibitors development for cancer therapy: Progress from 2021 to 2025.
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  Data: <searchLink fieldCode="AU" term="%22Gao+HN%22">Gao HN</searchLink>; Provincial Engineering Laboratory for Screening and Re-evaluation of Active Compounds of Herbal Medicines in Southern Anhui, School of Pharmacy, Wannan Medical College, Wuhu, 241000, PR China.<br /><searchLink fieldCode="AU" term="%22Wu+XS%22">Wu XS</searchLink>; Provincial Engineering Laboratory for Screening and Re-evaluation of Active Compounds of Herbal Medicines in Southern Anhui, School of Pharmacy, Wannan Medical College, Wuhu, 241000, PR China.<br /><searchLink fieldCode="AU" term="%22Pan+ZJ%22">Pan ZJ</searchLink>; Provincial Engineering Laboratory for Screening and Re-evaluation of Active Compounds of Herbal Medicines in Southern Anhui, School of Pharmacy, Wannan Medical College, Wuhu, 241000, PR China.<br /><searchLink fieldCode="AU" term="%22Liu+HM%22">Liu HM</searchLink>; Provincial Engineering Laboratory for Screening and Re-evaluation of Active Compounds of Herbal Medicines in Southern Anhui, School of Pharmacy, Wannan Medical College, Wuhu, 241000, PR China.<br /><searchLink fieldCode="AU" term="%22Chen+KQ%22">Chen KQ</searchLink>; Provincial Engineering Laboratory for Screening and Re-evaluation of Active Compounds of Herbal Medicines in Southern Anhui, School of Pharmacy, Wannan Medical College, Wuhu, 241000, PR China.<br /><searchLink fieldCode="AU" term="%22Teng+MX%22">Teng MX</searchLink>; Provincial Engineering Laboratory for Screening and Re-evaluation of Active Compounds of Herbal Medicines in Southern Anhui, School of Pharmacy, Wannan Medical College, Wuhu, 241000, PR China.<br /><searchLink fieldCode="AU" term="%22Zhao+JT%22">Zhao JT</searchLink>; School of Pharmacy & State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, 730000, PR China.<br /><searchLink fieldCode="AU" term="%22Zhou+J%22">Zhou J</searchLink>; Provincial Engineering Laboratory for Screening and Re-evaluation of Active Compounds of Herbal Medicines in Southern Anhui, School of Pharmacy, Wannan Medical College, Wuhu, 241000, PR China; Center for Reproductive Medicine, The First Affiliated Hospital of Wannan Medical College, Wuhu, 241000, PR China.<br /><searchLink fieldCode="AU" term="%22You+QD%22">You QD</searchLink>; Jiangsu Key Laboratory of Drug Design and Optimization and State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 210009, PR China; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, PR China. Electronic address: youqd@163.com.<br /><searchLink fieldCode="AU" term="%22Zhang+C%22">Zhang C</searchLink>; Provincial Engineering Laboratory for Screening and Re-evaluation of Active Compounds of Herbal Medicines in Southern Anhui, School of Pharmacy, Wannan Medical College, Wuhu, 241000, PR China. Electronic address: zhangchao@wnmc.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%220420510%22">European journal of medicinal chemistry</searchLink> [Eur J Med Chem] 2026 Feb 15; Vol. 304, pp. 118490. <i>Date of Electronic Publication: </i>2025 Dec 15.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Editions+Scientifiques+Elsevier%22">Editions Scientifiques Elsevier </searchLink><i>Country of Publication: </i>France <i>NLM ID: </i>0420510 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1768-3254 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2202235234%22">02235234 </searchLink><i>NLM ISO Abbreviation: </i>Eur J Med Chem <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.ejmech.2025.118490
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              Text: 2026 Feb 15
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